REGULATORY FACTORS IN THE GI TRACT

胃肠道的调节因素

• 批准号: 7846282
• 负责人: Nicholas O. Davidson
• 金额: $ 5.23万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7846282
• 关键词: REGULATORY; FACTORS; GI; TRACT

DESCRIPTION (provided by applicant): This application is for continued support of the Digestive Diseases Research Core Center (DDRCC) at Washington University St. Louis, focusing on regulatory factors in the GI tract. We believe that by gaining a fundamental understanding of the regulation of GI-processes, we will be able to more rationally prevent and treat GI diseases, including peptic ulcer, inflammatory bowel disease and acute and chronic liver diseases. Our philosophy is that the most effective way to develop new opportunities in digestive diseases related research is to invest in motivated individuals, especially at early stages of their careers. Consequently, the Washington University DDRCC focuses on mentoring and training students, residents, fellows and junior faculty with the goal of fostering new independent investigators in digestive diseases-related research. This center has excelled in developing young independent researchers though our Pilot/Feasibility Program. Our success can also be measured by the fact that both total extramural and NIDDK digestive diseases-related research base has more than doubled since the center's inception in 2000. The programmatic themes of the Digestive Diseases Research Core Center reflect its outstanding research base and are: 1.) Host-microbial interactions, inflammation and mucosal immunity; 2.) Gut development, differentiation and epithelial renewal; 3.) Nutrient transport, metabolism and signaling; 4.) Hepatobiliary metabolism, injury-repair. Washington University DDRCC investigators have been at the forefront in each of these programmatic themes. Partnership between a junior DDRCC investigator and clinical gastroenterologist has led to a novel paradigm in the treatment of inflammatory bowel disease. DDRCC investigators have pioneered the use of DNA microarray analyses of laboratory and clinical human samples to identify novel biomarkers and mediators in each of the four programmatic themes. These successes have in turn prompted us to propose to expand the Research Core services, including gnotobiotics, laser capture microdissection, DNA microarray, proteomics and bioinformatics. The goals of this DDRCC are to continue to promote and enhance interdisciplinary digestive disease research through its four research core facilities (Murine Models, Morphology, Functional Genomics and Proteomics).

描述（由申请人提供）： 该申请旨在持续支持圣路易斯华盛顿大学消化疾病研究核心中心 (DDRCC)，重点关注胃肠道的调节因素。我们相信，通过对胃肠道过程调节的基本了解，我们将能够更合理地预防和治疗胃肠道疾病，包括消化性溃疡、炎症性肠病以及急慢性肝病。我们的理念是，在消化系统疾病相关研究中开发新机会的最有效方法是投资于有积极性的个人，尤其是在其职业生涯的早期阶段。因此，华盛顿大学 DDRCC 专注于指导和培训学生、住院医师、研究员和初级教师，目标是培养消化系统疾病相关研究的新独立研究者。该中心通过我们的试点/可行性计划在培养年轻独立研究人员方面表现出色。我们的成功还可以通过以下事实来衡量：自 2000 年中心成立以来，校外和 NIDDK 消化系统疾病相关研究基地总数增加了一倍多。消化系统疾病研究核心中心的规划主题反映了其杰出的研究基地，包括： 1.) 宿主-微生物相互作用、炎症和粘膜免疫； 2.) 肠道发育、分化和上皮更新； 3.) 营养物质运输、代谢和信号传导； 4.) 肝胆代谢，损伤修复。华盛顿大学 DDRCC 的研究人员一直处于这些计划主题的最前沿。一位初级 DDRCC 研究员和临床胃肠病学家之间的合作开创了治疗炎症性肠病的新范例。 DDRCC 研究人员率先使用 DNA 微阵列分析实验室和临床人体样本来识别四个主题中的新生物标志物和介质。这些成功反过来又促使我们提议扩大研究核心服务，包括抗生素、激光捕获显微切割、DNA 微阵列、蛋白质组学和生物信息学。 DDRCC 的目标是通过其四个研究核心设施（小鼠模型、形态学、功能基因组学和蛋白质组学）继续促进和加强跨学科消化疾病研究。