The University of Michigan George M O'Brien Renal Core Center

密歇根大学乔治·M·奥布莱恩肾脏核心中心

• 批准号: 7916138
• 负责人: Frank C Brosius
• 金额: $ 30.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916138
• 关键词: Affect; African American; Animal Model; Applied Genetics; Automobile Driving; Back; Basic Science; Biological Models; Childhood; Clinic; Clinical; Clinical Trials; Collaborations; Communities; Cost Sharing; Databases; Decision Analysis; Descriptor; Development; Disease; Elements; Faculty; Genetic Predisposition to Disease; Genome; Genotype; Goals; Grant; Hispanics; Histology; Human; Individual; Institution; Intervention; Investigation; Kidney; Kidney Diseases; Knowledge; Lighting; Maintenance; Maps; Medical Students; Medicine; Michigan; Microscopy; Minority; Molecular; Online Systems; Outcome; Pathologic; Pathway interactions; Phenotype; Population; Postdoctoral Fellow; Prevention; Prevention approach; Private Sector; Process; Recruitment Activity; Renal glomerular disease; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Signal Pathway; Signal Transduction; Staging; Structure; System; Systems Biology; Talents; Technology; Therapeutic; Transgenic Organisms; Translating; Translational Research; Translations; Universities; Viral Vector; Work; age group; base; biobank; clinical application; clinical phenotype; high risk; human disease; molecular marker; molecular pathology; new technology; programs; response; sample collection; tool; transcriptomics; user-friendly

DESCRIPTION, OVERALL (provided by applicant): The focus for the George M. O'Brien Kidney Centers has been basic science investigation that has very successfully defined kidney structure, function and disease mechanisms. New technologies now provide opportunities to translate these remarkable basic science advances to the clinic in ways not previously imaginable. Advances in identification of genetic susceptibilities as well as the advent of the genome project and systems biology technologies set the stage for development of molecular maps that can be superimposed on traditional pathologic and functional descriptors so as to define diseases in a new way. These developments have important implications for definition of molecular markers that will allow accurate individualized prediction of outcome and response to therapy, and the identification of key pathways for therapeutic attack. The University of Michigan has developed and recruited expertise to help exploit these opportunities for people with kidney diseases. The realization of these opportunities requires collaborations between investigators world-wide for the collection of samples from well characterized individuals and populations, the application of technologies that facilitate information availability and exchange, the development and maintenance of databanks, and the integration of these technologies between human diseases, animals models, cellular systems and molecular signaling so as to define key pathways driving renal disease processes. Towards these goals the O'Brien Kidney Research Core Center at the University of Michigan will support four Cores: A. An Applied Systems Biology Core that has developed the platforms and infrastructure necessary to serve the integrative functions outlined above; B. A Clinical Phenotyping and Biobank Core that will collect the biosamples from affected characterized individuals; C. An Applied Genetics Core that will perform mutational analysis for genotype/phenotype matching; and D. A Basic Research Enhancement Core that will facilitate basic science development, integration and translation. These cores together with the Pilot and Feasibility Projects and Educational Enhancement Program in the Administrative Core will coordinate the grant, utilize the Cores and attract and support new talent into kidney research. The University of Michigan will provide $1,000,000 in supplemental support for the Center. The aim is to develop a structure which will serve local and national kidney investigators and the kidney community at large. Using web based tools, we will provide the basis for new understanding of disease-specific molecular pathology that can be used by every kidney investigator in the public and private sector world-wide.

描述，总体（由申请人提供）： 乔治·M·奥布莱恩肾脏中心的重点是基础科学研究，其成功定义了肾脏结构，功能和疾病机制。现在，新技术提供了将这些非凡的基础科学进步转化为以前无法​​想象的方式的诊所的机会。鉴定遗传敏感性的进步以及基因组项目和系统生物学技术的出现为开发分子图的发展奠定了基础，这些分子图可以叠加在传统的病理学和功能描述符上，以便以新的方式定义疾病。这些发展对分子标记的定义具有重要意义，这将允许对结果和对治疗的反应进行准确的个性化预测，并确定治疗攻击的关键途径。密歇根大学已经发展并招募了专业知识，以帮助为肾脏疾病患者开发这些机会。这些机会的实现需要全球调查人员之间的合作，以收集来自特征良好的个人和人群的样本，促进信息可用性和交换的技术的应用，数据库的开发和维护，以及这些技术的整合，在人类疾病，动物模型，细胞系统模型和分子信号传播等人类疾病中，以及肾脏疾病驱动肾脏疾病的过程。为了这些目标，密歇根大学的奥布莱恩肾脏研究核心中心将支持四个核心：A。应用系统生物学核心，该核心开发了为服务上面概述的综合功能所必需的平台和基础设施； B.一种临床表型和生物库核心，将从受影响的个体中收集生物样本； C.一种应用的遗传学核心，将对基因型/表型匹配进行突变分析； D.基础研究增强核心，将促进基础科学发展，整合和翻译。这些核心以及行政核心中的飞行员和可行性项目以及教育增强计划将协调赠款，利用核心并吸引并支持新人才进入肾脏研究。密歇根大学将为该中心提供1,000,000美元的补充支持。目的是开发一种将为当地和国家肾脏调查员和整个肾脏社区提供服务的结构。使用基于Web的工具，我们将为疾病特异性分子病理学的新理解提供基础，这些病理可以被全球公共和私营部门的每个肾脏研究者使用。