Mental Retardation and Developmental Disabilities Research Centers 2006

精神发育迟滞和发育障碍研究中心 2006 年

• 批准号: 7932047
• 负责人: SCOTT Loren POMEROY
• 金额: $ 17.25万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7932047
• 关键词: Mental; Retardation; Developmental; Disabilities; Research

DESCRIPTION (Provided by applicant): This Center grant requests funding for seven Core facilities to support a broadly-based research program in the study of mental retardation and developmental disabilities. The seven Core facilities are: Administrative, Proteomics, Cellular Neuroscience, Imaging, Gene Manipulation, Molecular Genetics, and Cell Sorter. The cores have undergone major development and support 123 research projects and 73 investigators. The research is in two programmatic areas (Neuroscience and Genetics). In Neuroscience, there are two major programs (Basic Neuroscience and Clinical/Translational Neuroscience). The Basic Neuroscience Program, directed by the Center Director, Dr. Michael Greenberg, consists of 47 investigators whose research efforts span a broad spectrum of interdigitated research in molecular neuroscience and systems neurobiology. A research project in Basic Neuroscience, proposed in this grant as a "New Program," addresses " the function of the GTPase regulatory enzyme, ephexin5, in synapse formation and dendritic spine development" (Mustafa Sahin, M.D., Ph.D.). A second major program in Neuroscience, i.e., Clinical/Translational Neuroscience, directed by Dr. Scott Pomeroy, includes 15 investigators whose research efforts include such areas as neuro-oncology, brain injury, brain behavior and brain development in neonates, human visual development, HIV, heart disease, surgery, and the developing brain, in vivo studies of brain development, neurocognitive development, developmental neuropsychology and learning disabilities, and endogenous and exogenous pxins and brain development. These areas of clinical research interdigitate with the basic research in the MRDDRC. In Genetics, directed by Dr. Louis Kunkel, 11 investigators are studying the molecular genetics of neuromuscular disease and human cerebral cortical development, the molecular basis of genetic disorders, retinal development and degenerative disorders, signal transduction, muscle stem cells, the genetics of complex traits and inherited musculoskeletal disorders. The multidisciplinary approaches to the research of this MRDDRC include the various basic science disciplines within Genetics and Neuroscience, and the clinical science fields of Neurology, Pediatrics, Neonatology, Infectious Disease, Endocrinology, Metabolism, Genetics, Cardiology, Neuropathology, Ophthalmology, Psychiatry, and Psychology. The research programs are housed in over 142,000 sq. ft. in two research buildings at Children's Hospital and several other facilities within the Harvard-Longwood Medical Area.

描述（由申请人提供）：该中心赠款要求为七个核心设施提供资金，以支持一项基于智力障碍和发育障碍研究的基于广泛的研究计划。七个核心设施是：行政，蛋白质组学，细胞神经科学，成像，基因操纵，分子遗传学和细胞分散者。核心经历了重大发展并支持123个研究项目和73名调查人员。该研究在两个程序化领域（神经科学和遗传学）。在神经科学中，有两个主要程序（基本的神经科学和临床/转化神经科学）。由中心主任迈克尔·格林伯格（Michael Greenberg）指导的基本神经科学计划由47位研究人员组成，其研究工作涵盖了分子神经科学和系统神经生物学方面的广泛相互作用的研究。基本神经科学的研究项目，在这笔赠款中提出，作为“新程序”，介绍了“ GTPase调节酶，Ephexin5，在突触形成和树突状脊柱发展中的功能”（Mustafa Sahin，M.D。M.D.，Ph.D。）。 A second major program in Neuroscience, i.e., Clinical/Translational Neuroscience, directed by Dr. Scott Pomeroy, includes 15 investigators whose research efforts include such areas as neuro-oncology, brain injury, brain behavior and brain development in neonates, human visual development, HIV, heart disease, surgery, and the developing brain, in vivo studies of brain development, neurocognitive development, developmental neuropsychology and learning disabilities, and endogenous和外源性PXIN和大脑发育。这些临床研究领域与MRDDRC的基础研究相互互动。在遗传学中，由路易斯·昆克尔（Louis Kunkel）博士指导，11名研究者正在研究神经肌肉疾病和人类脑皮质发育的分子遗传学，遗传疾病的分子基础，视网膜发育和退化性疾病，信号转导，信号过量，肌肉干细胞，肌肉干细胞，复杂的特征性肌肉和遗传性肌肉的遗传学和遗传性肌肉症的遗传学。该MRDDRC研究的多学科方法包括遗传学和神经科学中的各种基础科学学科，以及神经学，儿科，新生儿学，传染病，内分泌学，代谢，遗传学，心脏病学，神经病理学，神经病理学，心理学，心理学，心理学，心理学，心理学，心理学，心理学，心理学，心理学，心理学和心理学。该研究计划在儿童医院的两座研究楼和哈佛长伍德医疗区域内的其他几个设施中安置在超过142,000平方英尺的位置。