Imaging Core

成像核心

• 批准号: 7613236
• 负责人: Richard J. Schwab
• 金额: $ 28.9万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7613236
• 关键词: Abdomen; Collaborations; Computer Analysis; Computer software; Core Facility; Data; Data Analyses; Data Display; Development; Ensure; Family; Fatty acid glycerol esters; Funding; Human; Iceland; Image; Image Analysis; Imagery; Leadership; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Modeling; Monitor; Obesity; Obstructive Sleep Apnea; Pennsylvania; Picture Archiving and Communication System; Procedures; Process; Quality Control; Reproducibility; Research; Research Project Grants; Rodent; Role; Running; Sleep Apnea Syndromes; Standardization; Structure; The Sun; Three-Dimensional Image; Three-dimensional analysis; Tongue; Training; United States National Institutes of Health; Universities; Visceral; abdominal fat; cost effectiveness; craniofacial; endophenotype; image processing; lung imaging; novel; programs; quality assurance; radiologist; reconstruction; soft tissue

The Imaging Core, located in the Pulmonary Imaging Center will act as a central facility to handle and process the large number of MRI's and MR data analysis generated by Projects 01, 02 and 03. The objectives of the Imaging Core are to: 1) transfer data from the MRI to the Pulmonary Imaging Center; 2) ensure proper data analysis of the MR images, 3) perform quantitative analysis of upper airway soft tissue and craniofacial structures on spin echo MRI, quantify tongue fat with Dixon imaging and MR spectroscopy, quantify visceral abdominal fat, quantify LV size and aortic stiffness; 4) ensure quality control of the MR images; and 5) establish new computer analysis three-dimensional image analysis programs. The MR images will be electronically transferred to the Pulmonary Imaging Center via a Picture Archiving and Communication System (PACS). The image analysis will be performed in the Pulmonary Imaging Center where there are 4 Sun workstations running a completely novel software package developed for the analysis of three-dimensional images (Volumetric Image Display and Analysis, VIDA). We will also utilize AMIRA software - Advanced Visualization and Volume Modeling for volumetric display of the data. TheMR data analysis is complicated and cannot be performed without significant training. Dr. Schwab has been the director of the Pulmonary Imaging Center since 1991 and has an established track record for analyzing such data. The large number of MRI's justifies the establishment of a core devoted to the performing the complicated analysis proposed in Projects 01, 02 and 03. A centralized facility will ensure quality control of the data and cost effectiveness. We will perform MRI's at the University of Pennsylvania and in Iceland. We have already had a successful collaboration with the Iceland MR team in a large ongoing NIH funded Icelandic study ("A Family Linkage Study of Obstructive Sleep Apnea" (HL072067)) in which 391 MRI's of the upper airway and of visceral abdominal fat have been performed. Over 300 of these MRI's have already been analyzed. The Magnetic Resonance Imaging Core will be under the leadership of Dr. Richard Schwab with support staff consisting of senior research radiologists (visceral abdominal fat (Dr. Torigian), MR spectroscopy (Dr. Poptani), image processing, reconstruction and threshold analysis (Dr. Udupa) and two research technicians to perform and validate the image analysis. Development of a central core facility with expertise in upper airway and volumetric abdominal visceral fat imaging will facilitate the proposed research by standardizing the imaging analysis paradigms, allow the development of new image analysis approaches and ensure quality assurance/reproducibility across all three research projects.

位于肺部成像中心的成像核心将作为中央设施来处理和 处理项目 01、02 和 03 生成的大量 MRI 和 MR 数据分析。 成像核心的目标是： 1) 将数据从 MRI 传输到肺部成像中心； 2） 确保 MR 图像的正确数据分析，3) 对上呼吸道软组织进行定量分析 旋转回波 MRI 上的颅面结构，使用 Dixon 成像和 MR 波谱量化舌头脂肪， 量化内脏腹部脂肪、量化左心室大小和主动脉僵硬度； 4）确保MR的质量控制 图像； 5)建立新的计算机分析三维图像分析程序。先生 图像将通过图片存档以电子方式传输至肺部成像中心 通信系统（PACS）。图像分析将在肺部影像中心进行 其中有 4 个 Sun 工作站，运行为该系统开发的全新软件包。 三维图像分析（体积图像显示和分析，VIDA）。我们还将利用 AMIRA 软件 - 用于数据体积显示的高级可视化和体积建模。 MR 数据分析很复杂，如果没有经过大量培训就无法进行。施瓦布博士一直是 自 1991 年起担任肺部影像中心主任，并在分析方面拥有良好的记录 这样的数据。大量的 MRI 证明有必要建立一个专门用于执行核磁共振成像的核心 项目 01、02 和 03 中提出的复杂分析。集中设施将确保质量控制 数据和成本效益。我们将在宾夕法尼亚大学和冰岛进行核磁共振检查。 我们已经与冰岛 MR 团队在 NIH 资助的大型正在进行中进行了成功合作 冰岛研究（“阻塞性睡眠呼吸暂停的家庭关联研究”(HL072067)），其中 391 次 MRI 检查 已对上呼吸道和内脏腹部脂肪进行了检查。其中 300 多个 MRI 已经 被分析了。磁共振成像核心将由 Richard Schwab 博士领导 由高级研究放射科医生组成的支持人员（内脏腹部脂肪（Torigian 博士）、MR 光谱学（Poptani 博士）、图像处理、重建和阈值分析（Udupa 博士）和两个 研究技术人员执行和验证图像分析。开发中央核心设施 上呼吸道和腹部内脏脂肪容积成像方面的专业知识将促进拟议的研究 通过标准化成像分析范式，允许开发新的图像分析方法 并确保所有三个研究项目的质量保证/可重复性。