Genetic and Environmental Effects on Clinical Cardiovascular Events in a Large Co

遗传和环境对大型公司临床心血管事件的影响

基本信息

批准号：
7921751
负责人：
Redford B WILLIAMS
金额：
$ 59.23万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7921751
关键词：
9p21 Agonist Behavioral Behavioral Genetics Biological Biology Blood Platelets Candidate Disease Gene Cardiac Catheterization Procedures Cardiovascular Diseases Cardiovascular system Cause of Death Cessation of life Characteristics Chromosomes Clinical Clinical Data Complex Coronary Arteriosclerosis Databases Development Disease Disease susceptibility Evaluation Event Exposure to Functional disorder Funding Genes Genetic Genetic Polymorphism Genotype Glucose Goals Grant Health Hypertension Individual Intervention Investigation Knowledge Link Lipids Maps Mediating Metabolic Metabolic syndrome Modeling Molecular Myocardial Infarction National Heart, Lung, and Blood Institute Nature Non-Insulin-Dependent Diabetes Mellitus Outcome Pathogenesis Pathway interactions Patients Persons Phenotype Population Preventive Program Research Project Grants Reporting Research Personnel Resources Risk Risk Factors Sampling Stress Susceptibility Gene Techniques Testing Time Translating United States University Hospitals Variant Work adjudicate biobank cardiovascular risk factor cohort endophenotype environmental stressor follow-up genetic variant genome wide association study improved insight outcome forecast prevent programs psychosocial trait

项目摘要

The overarching objective of this Project is to identify genetic variants that are associated, both as main effects and via interactions with exposure to environmental stressors, with incident cardiovascular events or coronary artery disease (CAD). To accomplish this goal, we will evaluate genes found associated in Projects 1 and 2 with CVD endophenotypes or in Project 3 with hypertension or type II diabetes (T2D), for associations with incident cardiovascular events and angiographically documented CAD in the CATHGEN sample of approximately 10,000 patients who have undergone cardiac catheterization at Duke since 2001. CATHGEN is a unique resource of biological samples collected at time of cardiac catheterization combined with a carefully adjudicated clinical database comprising angiographically-defined extent and anatomical distribution of coronary artery disease, extensive clinical data on CHD risk factors, and annual follow-up for evaluation of incident cardiovascular events. The CATHGEN investigators, under non-overlapping support from their NHLBI grant, will be evaluating a broad range of genes that are biologically plausible contributors to CHD pathogenesis and/or course or have been reported to be associated with CHD for associations with CAD and clinical events. Therefore, another aim of this Project, will be to collaborate with Projects 1, 2 and 3 to determine whether any genetic variants we fmd associated with CAD or clinical events in the CATHGEN sample are also associated with CVD endophenotypes, hypertension and/or T2D in their samples. As with Project 3, this Project provides the opportunity to take the critical step of translating gene associations with CVD endophenotypes into documented impact on disease endpoints.

该项目的总体目的是确定与主要影响相关的遗传变异，并通过与环境压力源的相互作用，与进气心血管事件或冠状动脉疾病（CAD）相互作用。 To accomplish this goal, we will evaluate genes found associated in Projects 1 and 2 with CVD endophenotypes or in Project 3 with hypertension or type II diabetes (T2D), for associations with incident cardiovascular events and angiographically documented CAD in the CATHGEN sample of approximately 10,000 patients who have undergone cardiac catheterization at Duke since 2001. CATHGEN is a unique resource of biological samples collected at time of cardiac导管插入术与仔细裁决的临床数据库结合了冠状动脉疾病的血管造影定义的程度和解剖学分布，有关CHD危险因素的广泛临床数据以及评估入射心血管事件的年度随访。在其NHLBI赠款的非重叠支持下，Cathgen研究人员将评估广泛的基因，这些基因在生物学上是对CHD发病机理和/或过程的可可贡献者，或者据报道与CAD和临床事件有关的CHD与CHD有关。因此，该项目的另一个目的是与项目1、2和3合作，以确定我们与CADGEN样本中与CAD或临床事件相关的任何遗传变异也与样品中的CVD内表型，高血压和/或T2D有关。与项目3一样，该项目提供了将基因关联与CVD内型型转化为对疾病终点的有记录影响的关键步骤。