NONLINEAR OPTICAL ABSORPTION OF DNA-FUNCTIONALIZED CARBON NANOTUBES

DNA 功能化碳纳米管的非线性光学吸收

• 批准号: 8168106
• 负责人: LI ZHANG
• 金额: $ 2.33万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-19 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168106
• 关键词: Aging; Ammonia; Ascorbic Acid; Attention; Biocompatible Materials; Biosensing Techniques; Carbon Nanotubes; Chemicals; Computer Retrieval of Information on Scientific Projects Database; DNA; Disease; Enzymes; Exhibits; Film; Funding; Glucose; Grant; Hydrogen Peroxide; Institution; Lasers; Life; Molecular; Optics; Organism; Oxygen; Physiologic pulse; Physiological; Play; Polymers; Property; Proteins; Research; Research Personnel; Resources; Role; Source; System; Techniques; United States National Institutes of Health; absorption; chemical reaction; interest; nanobiosensor; nanosecond; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Single-walled carbon nanotubes are molecular wires that exhibit interesting structural, electrochemical, and optical properties. The near-infrared optical absorption properties of polymer- and biomaterial-functionalized single-walled carbon nanotubes have attracted particular attention for optical nanobiosensors. Deoxyribonucleic acids (DNAs) play important physiological and pathological roles in living organisms. The unique structural properties of single-walled carbon nanotubes make them extremely useful as a carrier of macromolecular enzymes and DNAs. Optical properties of DNA-functionalized single-walled carbon nanotubes are sensitive to many chemical and biological materials such as hydrogen peroxide, glucose, protein, oxygen, ammonia, and ascorbic acid. This provides us with useful approaches to develop optical biomedical sensing applications. Hydrogen peroxide is one of the main products for many enzyme-catalyzed chemical reactions. The over accumulation of hydrogen peroxide in living systems is related to aging and severe diseases. It has been found that the linear optical absorption properties of DNAfunctionalized carbon nanotubes in the near-infrared range significantly depend on the concentration of hydrogen peroxide. This proposed program concentrates on nonlinear optical absorption properties of double-stranded DNA-functionalized carbon nanotubes. We will use a nanosecond pulsed near-infrared laser system and employ the open aperture Z-san technique to characterize nonlinear optical absorption coefficient of the dispersions of double-stranded DNA-functionalized carbon nanotubes under different concentrations of hydrogen peroxide to determine the relation between the nonlinear optical absorption coefficient and the concentration of hydrogen peroxide. This research can be extended from the dispersions to the thin films of double-stranded DNA-functionalized carbon nanotubes during the academic year. The results will reinforce the potential of double-stranded DNA-functionalized carbon nanotubes for use in optical biosensing.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 单壁碳纳米管是分子线，具有有趣的结构，电化学和光学特性。聚合物和生物材料官能化的单壁碳纳米管的近红外光吸收特性引起了对光学纳米异种体的特别关注。 脱氧核糖核酸（DNA）在生物体中起重要的生理和病理作用。单壁碳纳米管的独特结构特性使其作为大分子酶和DNA的载体非常有用。 DNA官能化的单壁碳纳米管的光学特性对许多化学和生物材料（例如过氧化氢，葡萄糖，蛋白质，氧气，氨，氨和抗坏血酸）敏感。这为我们提供了开发光学生物医学传感应用的有用方法。 过氧化氢是许多酶催化化学反应的主要产物之一。 过度的过氧化氢在生物系统中与衰老和严重疾病有关。已经发现，近红外范围内DNA官能化的碳纳米管的线性光吸收特性显着取决于过氧化氢的浓度。该提议的程序集中在双链DNA官能化的碳纳米管的非线性光学吸收特性上。我们将使用纳米脉动脉冲近红外激光系统，并采用开放的孔径z-san技术来表征非线性光吸收系数的双链DNA官能化碳纳米管分散剂在不同浓度的过氧化氢中，以确定非线性的光接收器之间的关系，以确定浓度的浓度和浓度。这项研究可以从分散剂扩展到学年的双链DNA官能化碳纳米管的薄膜。结果将增强双链DNA官能化的碳纳米管的潜力，用于光学生物传感。