Training at the Chemistry: Biology Interface

化学：生物界面培训

基本信息

批准号：
7882598
负责人：
PAUL A. LINDAHL
金额：
$ 4.94万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-09-30 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7882598
关键词：
Biology Chemistry Training

项目摘要

DESCRIPTION (provided by applicant): Multidisciplinary research at the Chemistry: Biology interface has expanded so rapidly in the past few decades that such cross-training is now crucial for the development of the next generation of chemists and biologists. The objectives of the proposed training program at Texas A&M University are to train predoctotal graduate students in the Chemistry, Biochemistry and Biophysics, and Biology departments in research at the Chemistry: Biology Interface (CBI). Since its inception in 1994, this NIH-sponsored program has played a major role in the successful training of our graduate students in the molecular life sciences. The program currently involves 27 faculty members, with highly diverse research interests including : a) mechanistic enzymology (Raushel), b) macromolecular interactions (Hu, Reinhart, Schultz); c) synthesis (Burgess,Connell, Darensbourg, Romo, Yang); d) bioanalysis (Cremer, Russell, Vigh); e) metabolism (Begley, Lindahl,Watanabe); f) structure/function relationships (Barondeau, Hilty, Sacchettini); g) computational reaction mechanisms (Gao, Singleton); h) chronobiology (Golden and Bell-Pederson); i) behavioral biology (Garcia)and j) chemical biology (Pellois, Liu, Ryan, Young). Such diversity is a major strength of our CBI program, as it makes it attractive to a wider range of students and affords for greater cross-training at the Chemistry: Biology interface. Students in the CBI program choose one of these trainers as their primary research advisor, and enroll in a core group of required courses in which training in quantitative biology is stressed. CBI students enroll in a weekly journal club, in which research topics from this area are discussed, emphasizing the connection to human health, physiology and disease. Students also enroll in class on the Ethical Conduct of Research. The CBI program sponsors an annual symposium in which existing trainees present their research results and new trainees are introduced into the program. Well known external speakers are also invited as part of the training program. A former CBI student is invited to help current CBI students develop their careers. Towards the end of this 2-year program, students apply to attend a summer workshop course at an external location in which classroom and laboratory instruction are combined in an intense scientific setting. The CBI program also supports CBI students to attend a scientific conference annually.

描述（由申请人提供）：化学上的多学科研究：在过去的几十年中，生物学界面迅速扩展，以至于这种交叉培训对于下一代化学家和生物学家的发展至关重要。德克萨斯A＆M大学拟议的培训计划的目标是培训化学，生物化学和生物物理学以及化学研究的生物学部门研究生的研究生：生物学界面：生物学界面（CBI）。自1994年成立以来，这项由NIH赞助的计划在分子生活科学的研究生成功培训中发挥了重要作用。该计划目前涉及27名教职员工，具有高度多样化的研究兴趣，包括：a）机械酶学（Raushel），b）大分子相互作用（Hu，Reinhart，Schultz）； C）合成（Burgess，Connell，Darensbourg，Romo，Yang）； D）生物分析（Cremer，Russell，Vigh）； E）代谢（Begley，Lindahl，Watanabe）； f）结构/功能关系（Barondeau，Hilty，Sacchettini）； g）计算反应机制（GAO，Singleton）； h）Chronobiology（Golden and Bell-Pederson）； i）行为生物学（Garcia）和J）化学生物学（Pellois，Liu，Ryan，Young）。这种多样性是我们CBI计划的主要优势，因为它使其对更广泛的学生有吸引力，并且为化学：生物学界面提供了更大的交叉训练。 CBI计划中的学生选择其中一名教练作为其主要研究顾问，并参加了一组核心的必需课程，其中强调了定量生物学培训。 CBI学生参加了每周一次的期刊俱乐部，其中讨论了该领域的研究主题，强调了与人类健康，生理和疾病的联系。学生还参加研究的道德行为。 CBI计划赞助了一年一次的研讨会，现有学员介绍他们的研究结果，并将新学员引入该计划。著名的外部演讲者也被邀请作为培训计划的一部分。邀请了一名前CBI学生帮助现任CBI学生发展职业。在这项为期两年的计划结束时，学生申请在外部地点参加夏季研讨会课程，在外部地点，在该课程和实验室教学中，在强烈的科学环境中合并了。 CBI计划还支持CBI学生每年参加科学会议。

项目成果

期刊论文数量（72）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Perturbations to the active site of phosphotriesterase.

DOI：
10.1021/bi962099l
发表时间：
1997-02
期刊：
Biochemistry
影响因子：
2.9
作者：
J. Kuo;M. Chae;F. Raushel
通讯作者：
J. Kuo;M. Chae;F. Raushel

De novo design and spectroscopic characterization of a dinucleating copper-binding pentadecapeptide.

双核铜结合十五肽的从头设计和光谱表征。

DOI：
10.1021/ic051577q
发表时间：
2006
期刊：
Inorganic chemistry.
影响因子：
0
作者：
Rockcliffe,DavidA;Cammers,Arthur;Murali,Ayaluru;Russell,WilliamK;DeRose,VictoriaJ
通讯作者：
DeRose,VictoriaJ

Biophysical characterization of iron in mitochondria isolated from respiring and fermenting yeast.

DOI：
10.1021/bi100558z
发表时间：
2010-07-06
期刊：
BIOCHEMISTRY
影响因子：
2.9
作者：
Morales, Jessica Garber;Holmes-Hampton, Gregory P.;Miao, Ren;Guo, Yisong;Muenck, Eckard;Lindahl, Paul A.
通讯作者：
Lindahl, Paul A.

NiN(2)S(2) complexes as metallodithiolate ligands to Rh(I), Rh(II) and Rh(III).

NiN(2)S(2) 作为金属二硫醇盐配体与 Rh(I)、Rh(II) 和 Rh(III) 形成络合物。

DOI：
10.1039/b605768c
发表时间：
2006
期刊：
Dalton transactions (Cambridge, England : 2003)
影响因子：
0
作者：
Jeffery,StephenP;Green,KaylaN;Rampersad,MarilynV;Reibenspies,JosephH;Darensbourg,MarcettaY
通讯作者：
Darensbourg,MarcettaY

Effects of substitution at serine 40 of tyrosine hydroxylase on catecholamine binding.

酪氨酸羟化酶丝氨酸 40 处的取代对儿茶酚胺结合的影响。