PA-06-555 Senior Scientist Research and Mentorship Award (K05)

PA-06-555 高级科学家研究和指导奖 (K05)

基本信息

批准号：
7900568
负责人：
GEORGE Edward WOODY
金额：
$ 12.59万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-10 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7900568
关键词：
Abuse Reporting Accounting Adherence Adolescent Adult Advisory Committees Affect Agonist Alcohol or Other Drugs use American Psychiatric Association Anti-Retroviral Agents Antidepressive Agents Attention deficit hyperactivity disorder Benzodiazepines Binding Brazil Buprenorphine Case Series Cessation of life Child Clinical Trials Network Consult Controlled Clinical Trials Counseling Crisis Intervention DSM-IV Data Delaware Dependence Dissociation Dropout Drug Kinetics Drug Metabolic Detoxication Drug abuse Drug usage Education Educational Activities Educational process of instructing Effectiveness Energy Intake Epidemiology Evaluation Family psychotherapy France Funding Goals Good Clinical Practice Group Therapy Guidelines HIV HIV vaccine Heroin Heroin Dependence Human immunodeficiency virus test Implant Incentives Individual Infection Inpatients International Intervention Interview Investigation Journals K-Series Research Career Programs Maintenance Malaysia Marijuana Abuse Medical Students Mental disorders Mentors Mentorship Methadone Methadyl Acetate Morphine Naloxone Naltrexone National Institute of Drug Abuse Opiate Addiction Opioid Opioid Receptor Oral Outcome Outpatients Pain management Paper Patient Self-Report Patients Persons Pharmaceutical Preparations Pharmacotherapy Philadelphia Physical Dependence Physicians Primary Health Care Prisons Problem behavior Procedures Property Propoxyphene Psychiatry Psychotherapy Publishing Recording of previous events Regulation Rehabilitation therapy Relapse Reporting Research Research Activity Research Design Research Personnel Residential Treatment Risk Russia Safety Schedule Senior Scientist Senior Scientist Award Study Section Substance abuse problem Subutex Time Urine Western Asia Georgia Withdrawal Work Writing addiction aged career control trial group counseling human subject protection improved member methadone maintenance overdose death post-market programs psychosocial quality assurance symposium treatment duration working group young adult

项目摘要

DESCRIPTION (provided by applicant): This competing renewal reflects my long-term research and career objectives to study addiction treatment, generate information that improves outcome and reduces the burden of addiction on others, expand international addiction research, and mentor young investigators for addiction research careers. To this end, I have been PI or a Co-l on studies on antidepressant pharmacotherapy, propoxyphene maintenance, methadone maintenance and its impact on HIV risk and infection, LAAM, buprenorphine, psychotherapy, a HIV vaccine, a rapid HIV test, HIV and drug use in Brazil and Russia, naltrexone for treating heroin addiction and reducing HIV risk in Russia and the U.S., methadone patients who do not stop opioid use, motivational incentives, motivational enhancement, and others as P.I. of the Delaware Valley Node of the Clinical Trials Network (CTN). I have been a member of NIDA study sections, the FDA Drug Abuse Advisory Committee, the DSM-IV Substance Abuse Work Group, CPDD Board of Directors, and the Board of Addiction Psychiatry for the American Psychiatric Association. I mentor young investigators, review papers for many journals, am associate editor of two, supervise residents, participate in medical student teaching, and co-directed the addictions component of the Philadelphia VA Center of Excellence until retiring from the VA in 2004. Research activities for the next 5 years include publishing results of the buprenorphine study of adolescent/young adult opioid dependent individuals that was a focus of the prior K award, finishing CTN studies in which our group is currently participating, developing CTN studies on the impact of integrating substance abuse interventions in primary care, completing a naltrexone implant study in St. Petersburg Russia and a methadone study Kiev, submitting a R01 to study the impact of naltrexone implant vs. oral naltrexone on adherence to antiretroviral medication in HIV+ heroin addicts in St. Petersburg, developing a study of thrice weekly Suboxone for Subutex addiction in the Republic of Georgia, and a study of Concerta for reducing HIV risk in adolescents with ADHD and marijuana abuse or dependence in Brazil, helping develop guidelines for integrating addiction and HIV treatment in Russia, consulting on a study of methadone maintenance in primary care and a study of implant buprenorphine, and developing a study to assess the impact of offering treatment to opioid dependent persons being released from prison. Current mentees are two VA/NIDA fellows, an INVEST fellow from Malaysia, and a mentee from Tbilisi. Educational activities include supervising a Penn resident, leading case conferences at Penn and the VA, participating in an addiction course for medical students, and working with international collaborators on research topics including study design, implementation, procedures for quality assurance, human subjects protection, writing papers, and facilitating Good Clinical Practice.

描述（由申请人提供）：这一竞争性更新反映了我的长期研究和职业目标，即研究成瘾治疗、生成可改善结果并减轻他人成瘾负担的信息、扩大国际成瘾研究以及指导年轻研究人员进行成瘾研究职业生涯。为此，我担任 PI 或 Co-l，从事抗抑郁药物治疗、丙氧芬维持治疗、美沙酮维持治疗及其对 HIV 风险和感染的影响、LAAM、丁丙诺啡、心理治疗、HIV 疫苗、快速 HIV 检测、HIV 和巴西和俄罗斯的吸毒情况、俄罗斯和美国用于治疗海洛因成瘾和降低艾滋病毒风险的纳曲酮、不停止阿片类药物使用的美沙酮患者、激励措施、激励措施增强，以及其他作为 P.I.临床试验网络 (CTN) 特拉华谷节点的成员。我曾是 NIDA 研究部门、FDA 药物滥用咨询委员会、DSM-IV 药物滥用工作组、CPDD 董事会以及美国精神病学协会成瘾精神病学委员会的成员。我指导年轻的研究人员，审阅许多期刊的论文，担任两本期刊的副主编，监督住院医师，参与医学生的教学，并共同指导费城退伍军人事务部卓越中心的成瘾部分，直到 2004 年从退伍军人事务部退休。未来 5 年的工作包括发布针对青少年/年轻成人阿片类药物依赖者的丁丙诺啡研究结果（这是先前 K 奖的重点）、完成我们小组目前参与的 CTN 研究、开展 CTN 研究探讨将药物滥用干预措施纳入初级保健的影响，完成俄罗斯圣彼得堡的纳曲酮植入研究和基辅的美沙酮研究，提交 R01 来研究纳曲酮植入与口服纳曲酮对 HIV+ 海洛因抗逆转录病毒药物依从性的影响圣彼得堡的吸毒者，正在开展一项每周三次的 Suboxone 治疗格鲁吉亚共和国 Subutex 成瘾的研究，以及一项用于减少艾滋病毒的 Concerta 研究巴西多动症和大麻滥用或依赖青少年的风险，帮助俄罗斯制定将成瘾和艾滋病毒治疗相结合的指南，就初级保健中的美沙酮维持研究和植入丁丙诺啡的研究提供咨询，并开展一项评估其影响的研究为从监狱释放的阿片类药物依赖者提供治疗。目前的学员包括两名 VA/NIDA 研究员、一名来自马来西亚的 INVEST 研究员和一名来自第比利斯的学员。教育活动包括监督宾夕法尼亚大学居民、在宾夕法尼亚大学和退伍军人管理局主持案例会议、参加医学生成瘾课程，以及与国际合作者就研究主题进行合作，包括研究设计、实施、质量保证程序、人类受试者保护、写作论文，并促进良好临床实践。