Examining the Persistence of Neurocognitive Benefits of Exercise

检查运动对神经认知的益处的持久性

• 批准号: 10719280
• 负责人: Kirk I Erickson
• 金额: $ 236.29万
• 依托单位: ADVENTHEALTH ORLANDO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719280
• 关键词: Address; Adherence; Adult; Aerobic Exercise; Age Years; Age-associated memory impairment; Alzheimer' s Disease; Amyloid beta-42; Attenuated; Behavior; Binding; Biological; Biological Assay; Blood; Body Composition; Brain; Cerebrovascular Circulation; Characteristics; Cognition; Cognitive; Data; Dose; Evaluation; Exercise; Functional Magnetic Resonance Imaging; Funding; Future; Genetic; Hippocampus; Inflammatory; Intervention; Intervention Studies; Intervention Trial; Lesion; Machine Learning; Magnetic Resonance Imaging; Maintenance; Measures; Mediating; Mediator; Moods; Neurocognition; Neurocognitive; Neuronal Plasticity; Outcome; Participant; Pathway interactions; Personality; Physical Fitness; Physical Function; Physical activity; Physiological; Positron-Emission Tomography; Predictive Factor; Prefrontal Cortex; Psychosocial Factor; Public Health; Randomized; Recommendation; Research Personnel; Rest; Sample Size; Science; Site; Sleep; Social Network; Socioeconomic Status; Structure; Testing; Underrepresented Minority; United States National Institutes of Health; VO2max; actigraphy; active control; active control group; active lifestyle; arterial stiffness; blind; brain health; brain morphology; cardiometabolism; cardiorespiratory fitness; cerebral atrophy; cognitive benefits; cognitive function; cognitive performance; cost effective; cytokine; dementia risk; design; exercise intensity; exercise intervention; expectation; follow-up; improved; light intensity; neural; neuroimaging marker; neuropathology; neurotrophic factor; primary endpoint; psychologic; randomized, clinical trials; response; secondary endpoint; treatment group; white matter; β-amyloid burden

Project Summary/Abstract Physical activity (PA) is one of the most promising approaches for mitigating age-related cognitive decline and risk for dementia, yet few sufficiently powered randomized clinical trials (RCT) targeting brain health outcomes have been conducted. Further, little is known about the biological pathways and moderators of the brain response to exercise. To address these gaps, we have conducted a multi-site, supervised, dose-response (150min/wk of moderate-intensity; 225min/wk of moderate-intensity; 150min/wk of light intensity), aerobic exercise RCT with brain health outcomes as the primary endpoints in 648 cognitively normal adults between 65-80 years of age. This study, Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE), was funded by the NIH in 2016. The RCT has been enormously successful in terms of exceeding sample size expectations, maintaining high adherence and compliance (>80%), minimal missing data, improving cardiorespiratory fitness, and achieving the expected distribution of under-represented minorities (25% non-white). The results from IGNITE are bound to be transformative, but there will remain many unanswered questions after the conclusion of IGNITE that we intend to address in this proposal. For example, does a 12-month aerobic exercise RCT have any persistent or protracted benefits to cognitive, neural, or neuropathological outcomes 5-years after the completion of the intervention? Was the RCT effective at modifying long-term exercise behaviors? Can we utilize the rich participant data of IGNITE to forecast who is more likely to maintain a physically active lifestyle after the completion of the intervention? How effective was the exercise RCT for modifying the accumulation of Alzheimer’s disease (AD) neuropathology over a 5-year follow-up? And, finally, if cognitive, brain, or markers of neuropathology are different as a function of group assignment 5-years after the completion of the intervention, which factors mediate those long-term benefits? The answers to these questions will have significant scientific and public health implications that we will address in a cost-effective manner by conducting a 5-year follow-up evaluation of IGNITE participants. We focus on 4 key aims and one discovery science aim: Aim 1: Test the effects of the IGNITE exercise RCT on cognitive performance 5-years after the completion of the intervention. Aim 2: Examine the extent to which participants maintained exercise behaviors 5-years after the completion of the intervention. Aim 3: Test whether the intervention modified 5-year accumulation of AD neuropathology. Aim 4: Test whether the exercise RCT influenced 5-year follow-up of neuroimaging markers of brain health. Discovery Science Aim: Explore whether participant characteristics at baseline predict long-term engagement in exercise behaviors after the completion of the intervention.

项目概要/摘要 体力活动（PA）是缓解与年龄相关的认知能力下降的最有前途的方法之一 痴呆症风险，但针对大脑健康结果的足够有力的随机临床试验（RCT）却很少 此外，人们对大脑的生物途径和调节剂知之甚少。 为了解决这些差距，我们进行了多地点、受监督的剂量反应。 （150分钟/周中等强度；225分钟/周中等强度；150分钟/周光强度），有氧 在 648 名认知正常的成年人中进行以大脑健康结果为主要终点的随机对照试验 这项研究调查了 65-80 岁运动干预试验中的神经认知增益。 （IGNITE）于 2016 年由 NIH 资助。RCT 在超过 样本量预期，保持高依从性和合规性 (>80%)，最小化缺失数据， 改善心肺健康，并实现代表性不足的少数群体的预期分布 （25% 非白人） IGNITE 结束后未解答的问题是我们打算在本提案中解决的。 为期 12 个月的有氧运动 RCT 对认知、神经或功能有任何持续或长期的益处吗？ 干预完成后 5 年的神经病理学结果 RCT 是否有效？ 我们能否利用 IGNITE 丰富的参与者数据来预测谁是？ 干预完成后更有可能保持积极的生活方式？效果如何？ 用于改变 5 年阿尔茨海默病 (AD) 神经病理学积累的运动随机对照试验 最后，认知、大脑或神经病理学标志物作为群体的功能是否有所不同？ 干预完成 5 年后，哪些因素会调节这些长期效益？ 这些问题的答案将对科学和公共卫生产生重大影响，我们将 我们通过对 IGNITE 参与者进行 5 年跟踪评估，以具有成本效益的方式解决问题。 重点关注 4 个关键目标和一个发现科学目标： 目标 1：测试 IGNITE 练习 RCT 对 目标 2：检查干预完成后 5 年后的认知表现。 参与者在干预完成 5 年后仍保持锻炼行为 目标 3：测试。 目标 4：测试干预是否改变了 AD 神经病理学的 5 年积累。 运动随机对照试验影响大脑健康神经影像标记物的 5 年随访。 探索参与者的基线特征是否可以预测长期参与锻炼行为 干预完成后。