High-performance SPECT for dynamic brain imaging

用于动态脑成像的高性能 SPECT

• 批准号: 10718519
• 负责人: Hamid Sabet
• 金额: $ 63.85万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10718519
• 关键词: Alzheimer' s Disease; Arizona; Back; Biological Models; Brain; Brain imaging; Cardiac; Cells; Clinical; Collaborations; Collimator; Compensation; Complex; Computed Tomography Scanners; Creativeness; Data; Dedications; Dementia; Development; Dimensions; Dose; Epilepsy; Evaluation; Floods; Frequencies; Gamma Cameras; Geometry; Goals; Head; Human; Image; Isotopes; Lasers; Lesion; Letters; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Mechanics; Modeling; Noise; Optics; Parkinson Disease; Patients; Performance; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Process; Property; REM Sleep Behavior Disorder; Research; Resolution; Semiconductors; Signal Transduction; Structure; System; Systems Integration; Technetium 99m; Technology; Thick; Tracer; Update; Vertebral column; Visualization; Work; attenuation; cancer imaging; clinical application; cost; density; design; detector; digital; fabrication; high resolution imaging; human imaging; human study; image reconstruction; imaging study; improved; mosaic pattern; novel; nuclear imaging; portability; prototype; screening; single photon emission computed tomography; targeted imaging; ultra high resolution

PROJECT SUMMARY/ABSTRACT: Brain Single Photon Emission Computed Tomography (SPECT) imaging has been of great importance for many clinical applications such as epilepsy, dementia, posttraumatic stress disorder, Alzheimer’s disease, Parkinson’s disease, and tumor imaging. The conventional dual-head gamma cameras (DHGCs) which have been the mainstay in nuclear imaging (specifically for cardiac screening) are not optimized for brain imaging where achieving simultaneously high resolution and high sensitivity is necessary. Depending on the collimator choice, DHGC resolution is 7-15 mm FWHM, which is not very useful to visualize fine structures of the human brain. There are several ongoing projects with the premise of improved scanner performance compared to the DHGC systems, however they are either focusing on using old detector technology and mainly improving the collimator geometry or focusing on very expensive (order of magnitude compared with the current designs) semiconductor technology which also leads to a complex system. With this application we seek to develop a portable SPECT scanner for dynamic brain imaging with ~4 mm FWHM resolution at the same sensitivity of the DHGC or 8x more sensitivity at 7 mm resolution. The backbone of the design is our enabling technology to fabricate high resolution detectors at practical cost. The proposed project will open new avenues for low dose brain SPECT imaging applications and enable longitudinal studies.

项目概要/摘要： 脑单光子发射计算机断层扫描 (SPECT) 成像对于 许多临床应用，如癫痫、痴呆、创伤后应激障碍、阿尔茨海默病、 帕金森病和肿瘤成像具有传统的双头伽玛相机（DHGC）。 一直是核成像（特别是心脏筛查）的支柱，但并未针对脑成像进行优化 需要同时实现高分辨率和高灵敏度，具体取决于准直器。 选择，DHGC 分辨率为 7-15 mm FWHM，这对于可视化人体精细结构不是很有用 与大脑相比，有几个正在进行的项目以提高扫描仪性能为前提。 然而，DHGC 系统要么专注于使用旧的探测器技术，要么主要改进 准直器几何形状或重点非常昂贵（与当前设计相比的数量级） 半导体技术也导致了复杂的系统。 通过此应用，我们寻求开发一款便携式 SPECT 扫描仪，用于 ~4 mm 的动态脑成像 FWHM 分辨率与 DHGC 的灵敏度相同，或者在 7 毫米分辨率下灵敏度高出 8 倍。 该设计的核心是我们以实际成本制造高分辨率探测器的技术。 该项目将为低剂量脑部 SPECT 成像应用开辟新途径，并实现纵向研究。