Upgrade to Multiuser 3T Magnetic Resonance Imager

升级到多用户 3T 磁共振成像仪

• 批准号: 7596804
• 负责人: Charles Dennis Smith
• 金额: $ 50万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-04 至 2010-05-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7596804
• 关键词: Affect; Aging; Alcoholism; Alzheimer' s Disease; Anatomy; Area; Arts; Autistic Disorder; Behavior; Biological Markers; Brain; Data; Degenerative Disorder; Dementia; Development; Diagnosis; Diffusion; Disease; Early Diagnosis; Equipment; Funding; Future; Goals; Grant; Human; Huntington Disease; Image; Imaging Techniques; Individual; Investigation; Kentucky; Magnetic Resonance; Measurement; Measures; Methodology; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Neurosciences; Neurosciences Research; Noise; Parkinson Disease; Positioning Attribute; Public Health; Research; Research Personnel; Research Project Grants; Screening procedure; Signal Transduction; Speed; Spinal Cord; Structure; System; Techniques; Technology; Therapeutic; United States National Institutes of Health; Universities; Weight; data acquisition; improved; instrument; instrumentation; nervous system disorder; normal aging; novel; programs; public health relevance; radiofrequency; reconstruction; spectroscopic imaging; tool; white matter

DESCRIPTION (provided by applicant): This proposal is for funding to upgrade a high-end 3T Siemens Trio MR imager at the University of Kentucky. The upgrade includes improvements to the gradients, the radiofrequency transmitter and receiver systems, and data acquisition and reconstruction systems of the imager and will significantly improve the imaging capabilities of the instrument, bringing it up to the state-of-the-art and providing a platform for future upgrades. The upgrade is essential to providing continued support for an outstanding group of eleven NIH funded researchers using this instrument as the central piece of experimental apparatus for their neuroscience research into developmental and degenerative diseases such as Parkinson's and Alzheimer's. The rapid development of MR technology and neuroscience research necessitates this upgrade and will position UK researchers to advance research into aging, dementia and other neurological diseases. With this upgrade UK neuroscience researchers will have the most sensitive imaging techniques to investigate non-invasively the causes and consequences of neurological diseases. In particular, the specific aims of this upgrade are to improve both the speed and signal-to- noise of image acquisition, the accuracy of image and spectroscopic measurements and to enable the acquisition of novel diffusion weighted data necessary to explore white matter structure and function. The equipment upgrade will benefit many important cutting-edge research projects such as the development of sensitive tools for early detection of Alzheimer's and Parkinson's diseases, understanding the areas of the brain involved in alcoholism and autism and understanding the connection between brain structure and behavior and function. The upgrade supports the long term goal of this group, which is the development of methodologies and tools for the study of brain anatomy and function in normal individuals and in subjects affected with neurodegenerative or congenital neurological conditions. The relevance of this equipment upgrade is that it will provide a nationally recognized group of neuroscience investigators with state-of-the-art research tools to greatly expand and enhance their investigations into the changes in the brain and spinal cord which occur with diseases such as Alzheimer's and Parkinson's as well as with normal aging and with therapeutic treatments including biomarkers for these conditions. Expanding this research program is crucial as the techniques developed from non-invasive imaging can easily and rapidly be applied to advancing public health through improved screening and diagnosis. PUBLIC HEALTH RELEVANCE: This Shared Instrumentation Grant will upgrade a multi-user, high field, MR imager to a state-of-the-art instrument for carrying out advanced neuroscience research at the University of Kentucky. The upgrade will add several new acquisition and analysis features to measure, through non-invasive imaging, the structure and function of the brain. These improvements are essential to continue research into the origin and causes of several neurodegenerative diseases including Parkinson's, Alzheimer's, Huntington's as well as normal human aging.

描述（由申请人提供）：该提案旨在资助升级肯塔基大学的高端 3T 西门子 Trio MR 成像仪。此次升级包括对梯度、射频发射器和接收器系统以及成像仪数据采集和重建系统的改进，将显着提高仪器的成像能力，使其达到最先进的水平，并提供为未来的升级提供平台。此次升级对于为由 11 名 NIH 资助的研究人员组成的杰出团队提供持续支持至关重要，该团队使用该仪器作为实验设备的核心部件，对帕金森症和阿尔茨海默氏症等发育性疾病和退行性疾病进行神经科学研究。 MR 技术和神经科学研究的快速发展使得这一升级成为必要，并将使英国研究人员能够推进对衰老、痴呆和其他神经系统疾病的研究。通过此次升级，英国神经科学研究人员将拥有最灵敏的成像技术，以非侵入性方式研究神经系统疾病的原因和后果。特别是，此次升级的具体目标是提高图像采集的速度和信噪比、图像和光谱测量的准确性，并能够采集探索白质结构和功能所需的新颖的扩散加权数据。此次设备升级将惠及许多重要的前沿研究项目，如开发早期检测阿尔茨海默氏症和帕金森氏症的灵敏工具、了解与酗酒和自闭症有关的大脑区域以及了解大脑结构与行为和功能之间的联系。此次升级支持该小组的长期目标，即开发用于研究正常个体和患有神经退行性或先天性神经系统疾病的受试者的大脑解剖结构和功能的方法和工具。此次设备升级的意义在于，它将为国家认可的神经科学研究小组提供最先进的研究工具，以极大地扩展和加强他们对以下疾病引起的大脑和脊髓变化的研究：阿尔茨海默氏症和帕金森氏症以及正常衰老和包括这些病症的生物标志物在内的治疗方法。扩大这一研究计划至关重要，因为非侵入性成像开发的技术可以轻松快速地应用于通过改进筛查和诊断来促进公共卫生。 公共健康相关性：这项共享仪器赠款将把多用户高场 MR 成像仪升级为最先进的仪器，用于在肯塔基大学开展先进的神经科学研究。此次升级将添加一些新的采集和分析功能，以通过非侵入性成像来测量大脑的结构和功能。这些改进对于继续研究帕金森氏症、阿尔茨海默氏症、亨廷顿氏症以及正常人类衰老等几种神经退行性疾病的起源和原因至关重要。