Evaluating the Link between HIV Prevention and Treatment

评估艾滋病毒预防和治疗之间的联系

基本信息

批准号：
7915512
负责人：
A. DAVID PALTIEL
金额：
$ 75.42万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7915512
关键词：
AIDS prevention AIDS/HIV problem Accounting Address Adult Advisory Committees Algorithms American Anti-HIV Agents Antigens Arts Attention Award Behavioral Biological Assay Budgets Caring Centers for Disease Control and Prevention (U.S.)Clinical Clinical Management Computer Simulation Computers Conflict (Psychology)Consent Counseling Data Detection Development Disease Economics Enzymes Epidemic Evaluation Failure Frequencies Funding Gender Guidelines HIV HIV Infections Health Health Policy Healthcare Human immunodeficiency virus test Immunosorbents Individual Infection Laboratories Life Link Medicaid Modeling National Institute of Mental Health Natural History Outcome Paper Peer Review Policies Policy Analysis Preventive Probability Protocols documentation Publishing Recommendation Reporting Research Resource Allocation Resources Risk Risk Assessment Risk Behaviors Screening procedure Series Services System Target Populations Technology Testing United States Viral load measurement Virus Western Blotting base cost cost effectiveness evidence base models and simulation prevent programs public health relevance racial and ethnic simulation sobriety transmission process

项目摘要

DESCRIPTION (provided by applicant): Of the estimated 1 million Americans who are currently infected with HIV, as many as 300,000 remain unaware of their infection and without access to life-prolonging care that could prevent further transmission. In 2002 and 2005, we were awarded funding to develop a computer-based evaluation model of the detection, clinical management, and economics of HIV disease. Our findings have had a profound impact on HIV screening policy and guideline development in the United States. Our aims for this competing continuation are: 1. To refine the simulation model to more accurately portray the detection and risk of HIV infection, the natural history of early HIV disease, and the impact of screening on secondary HIV transmission. 2. To conduct a series of policy evaluations on questions arising from the CDC's 2006 revised recommendations for expanded HIV screening. We will: " evaluate the CDC's proposed algorithms for HIV detection and confirmation in the US; " assess the cost-effectiveness of routine versus targeted strategies for HIV screening; " estimate the survival costs of inadequate HIV detection, linkage, and retention in the US; " forecast the budgetary impact of increased case identification and referral to care on the demand for publicly funded HIV services in the US (including Medicaid, the Ryan White CARE Act, and state AIDS Drug Assistance Programs). This proposal is motivated by several recent reports that identify inadequate HIV screening as a critical failing in the effort to contain the HIV epidemic in the US. This research plan will advance the state of the art in evidence-based, model-driven policy analysis. PUBLIC HEALTH RELEVANCE: Of the estimated 1 million Americans who are currently infected with HIV, roughly 300,000 remain unaware of their infection and without access to life-prolonging care that could prevent further transmission. This project uses a mathematical simulation model to assemble and analyze the best available clinical and cost data, to inform current policy debates, and to promote an evidence-based approach to HIV counseling, testing, and referral in the United States.

描述（由申请人提供）：目前估计有 100 万美国人感染艾滋病毒，其中多达 30 万人仍然不知道自己受到感染，也无法获得可防止进一步传播的延长生命的护理。 2002 年和 2005 年，我们获得资金开发基于计算机的 HIV 疾病检测、临床管理和经济学评估模型。我们的研究结果对美国的艾滋病毒筛查政策和指南的制定产生了深远的影响。我们这一竞争性延续的目标是： 1. 完善模拟模型，以更准确地描绘 HIV 感染的检测和风险、早期 HIV 疾病的自然史以及筛查对继发 HIV 传播的影响。 2. 对 CDC 2006 年扩大艾滋病毒筛查修订建议中出现的问题进行一系列政策评估。我们将：“评估疾病预防控制中心提出的美国艾滋病毒检测和确认算法；”评估常规艾滋病毒筛查策略与针对性策略的成本效益； “估计美国艾滋病毒检测、联系和保留不足的生存成本；”预测增加病例识别和转诊对美国公共资助的艾滋病毒服务需求（包括医疗补助、Ryan White CARE）的预算影响法和州艾滋病药物援助计划）。这项提议是由最近的几份报告提出的，这些报告认为艾滋病毒筛查不足是美国遏制艾滋病毒流行的一个严重失败。该研究计划将推进基于证据、模型驱动的政策分析的最先进水平。公共卫生相关性：目前估计有 100 万美国人感染艾滋病毒，其中约 30 万人仍然不知道自己受到感染，也无法获得可防止进一步传播的延长生命的护理。该项目使用数学模拟模型来收集和分析现有的最佳临床和成本数据，为当前的政策辩论提供信息，并在美国推广基于证据的艾滋病毒咨询、检测和转诊方法。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Integrating HIV screening into routine health care in resource-limited settings.

DOI：
10.1086/651477
发表时间：
2010-05-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
0
作者：
Bassett IV;Walensky RP
通讯作者：
Walensky RP

Integrating substance abuse treatment into HIV care: missed opportunities in the AIDS Drug Assistance Program.

DOI：
10.1097/qai.0b013e31827ee56c
发表时间：
2013-04-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
0
作者：
Martin EG;Wang KH
通讯作者：
Wang KH

Implications and impact of the new US Centers for Disease Control and prevention HIV testing guidelines.

新的美国疾病控制和预防中心艾滋病毒检测指南的含义和影响。

DOI：
10.1007/s11908-008-0027-6
发表时间：
2008
期刊：
Current infectious disease reports
影响因子：
3.1
作者：
Millen,JenniferC;Arbelaez,Christian;Walensky,RochelleP
通讯作者：
Walensky,RochelleP

Prevalence and correlates of clinically significant depressive symptoms in an urban hospital emergency department.

城市医院急诊科临床显着抑郁症状的患病率和相关性。

DOI：
10.4088/pcc.09m00817gry
发表时间：
2010
期刊：
Primary care companion to the Journal of clinical psychiatry
影响因子：
0
作者：
Mimiaga,MatthewJ;Reichmann,WilliamM;Safren,StevenA;Losina,Elena;Arbelaez,Christian;Walensky,RochelleP
通讯作者：
Walensky,RochelleP

HIV self-testing and the missing linkage.