The role of autoimmune natural IgM in human myocardial infarction

自身免疫天然IgM在人心肌梗死中的作用

• 批准号: 7846126
• 负责人: Ming Zhang
• 金额: $ 20.33万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7846126
• 关键词: Acute; Acute myocardial infarction; Antibodies; Autoantibodies; Autoantigens; Autoimmune Process; Basic Science; Clinical; Clinical Management; Goals; Human; Immunoglobulin M; Individual; Inflammation; Injury; Ischemia; Knowledge; Mediator of activation protein; Myocardial; Myocardial Infarction; Myocardium; Myosin Heavy Chains; Patients; Role; Societies; base; insight; mortality; non-muscle myosin; novel; novel marker; preclinical study; public health relevance; response

DESCRIPTION (provided by applicant): Myocardial infarction (MI) is a leading cause of mortality in today's society. Injury to myocardium is a manifestation of the intrinsic cellular response to ischemia and of an extrinsic acute inflammation. Recent pre-clinical studies have revealed that pre-existing natural IgM functions as the critical mediator between the intrinsic and extrinsic responses in injury induction. The goal of this proposal is to expand these novel basic science discoveries at the clinical level. Knowledge gained from this study will provide a new basis for clinical management of myocardial infarction. The specific aims are as follows: Aim 1. To determine whether natural IgM antibodies against an ischemia-specific self antigen (non-muscle myosin heavy chain II, NMHC-II) are present in normal individuals and patients with acute myocardial infarction. Aim 2. To investigate whether the levels of these autoimmune antibodies correlate with the degrees of myocardial injury. PUBLIC HEALTH RELEVANCE This study will provide important insight of a new mechanism in ischemic myocardial injury, and may identify new markers for myocardial infarction.

描述（由申请人提供）：心肌梗塞（MI）是当今社会死亡的主要原因。心肌损伤是细胞对缺血和外源性急性炎症的内在细胞反应的表现。最近的临床前研究表明，预先存在的天然 IgM 在损伤诱导中充当内在和外在反应之间的关键介质。该提案的目标是将这些新颖的基础科学发现扩展到临床水平。从这项研究中获得的知识将为心肌梗死的临床治疗提供新的基础。具体目标如下： 目的 1. 确定正常个体和急性心肌梗死患者中是否存在针对缺血特异性自身抗原（非肌肉肌球蛋白重链 II，NMHC-II）的天然 IgM 抗体。目的2.探讨这些自身免疫抗体的水平是否与心肌损伤程度相关。 公共卫生相关性 这项研究将为缺血性心肌损伤的新机制提供重要见解，并可能确定心肌梗死的新标志物。

项目成果

Natural antibody - Biochemistry and functions.

天然抗体 - 生物化学和功能。

• 发表时间: 2011
• 期刊: Global journal of biochemistry
• 作者: Rahyab,AliSeyar;Alam,Amit;Kapoor,Aricka;Zhang,Ming
• 通讯作者: Zhang,Ming

Human natural IgM can induce ischemia/reperfusion injury in a murine intestinal model.

人类天然 IgM 可在小鼠肠道模型中诱导缺血/再灌注损伤。

• DOI: 10.1016/j.molimm.2008.06.013
• 发表时间: 2008
• 期刊: Molecular immunology
• 影响因子: 3.6
• 作者: Zhang,Ming;Alicot,ElisabethM;Carroll,MichaelC
• 通讯作者: Carroll,MichaelC

MASP-2 activation is involved in ischemia-related necrotic myocardial injury in humans.

MASP-2 激活参与人类缺血相关的坏死性心肌损伤。

• DOI: 10.1016/j.ijcard.2011.11.032
• 发表时间: 2013
• 期刊: International journal of cardiology
• 影响因子: 3.5
• 作者: Zhang,Ming;Hou,YunfangJoan;Cavusoglu,Erdal;Lee,DanielC;Steffensen,Rudi;Yang,Liming;Bashari,Daniel;Villamil,Jose;Moussa,Motaz;Fernaine,George;Jensenius,JensC;Marmur,JonathanD;Ko,Wilson;Shevde,Ketan
• 通讯作者: Shevde,Ketan

A rare cause of dysphagia: malignant pleural mesothelioma in the posterior mediastinum.

吞咽困难的罕见原因：后纵隔恶性胸膜间皮瘤。

• DOI: 10.1016/j.athoracsur.2010.03.082
• 发表时间: 2010
• 期刊: The Annals of thoracic surgery
• 作者: Hayama,Makio;Maeda,Hiroya
• 通讯作者: Maeda,Hiroya

Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury

• DOI: 10.1073/pnas.1101748108
• 发表时间: 2011-05-03
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Schwaeble, Wilhelm J.;Lynch, Nicholas J.;Stover, Cordula M.
• 通讯作者: Stover, Cordula M.