CARDIA

贲门

• 批准号: 7789068
• 负责人: KIANG J LIU
• 金额: $ 142.42万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7789068
• 关键词: CARDIA

The Coronary Artery Risk Development in Young Adults (CARDIA) Study for the period 2003-8, is a population-based observational study of African-American and white men and women of diverse socioeconomic status that began by examining 5,115 young adults aged 18-30 in 1985-6. Follow-up examinations at years 2, 5, 7, 10, and 15 achieved high retention rates, collected a rich set of high quality data and stored specimens bearing on the causes of cardiovascular disease (CVD), and led to 168 peer-reviewed publications. During the next 5 years we will continue semi-annual telephone contacts, disease event surveillance, and analysis and publication activities. We will carry out a year 20 exam on our cohort, who will be 38-50 years old. We propose to re-examine at least 73% of those surviving (3,650 participants study-wide and 812 in Chicago) with 4 main objectives: 1. To identify predictors of development and progression of subclinical atherosclerosis; we will measure risk factor levels (established, novel, lifestyle, and psychosocial) and subclinical atherosclerosis (coronary artery calcification [CAC] and carotid intimal media thickness [IMT]). We will examine the antecedents of the risk factors with special attention to the growing epidemic of obesity, explore the effects of recent and remote risk factor exposure on CAC, on CAC progression, and on IMT, and assess the role of conditions such as obesity, diabetes, and renal impairment, and of differences in socio-economic status and health care access and utilization. 2. To elucidate possible racial differences in CVD pathogenesis, we will compare the factors associated with CAC incidence and prevalence, and with IMT prevalence, across risk-gender groups; we will explore factors that may explain observed differences. 3. To test whether inflammation precedes subclinical disease, we will examine the time course of the association between inflammatory markers (such as C-reactive protein) and CAC and IMT evidence for atherosclerosis. We will also identify predictors of inflammation (such as infection), and the impact of obesity and of visceral adiposity. 4. To assess the roles of genetic variation and gene by environment interactions in CVD pathogenesis, we will explore their role in the etiology of risk factors, and test if allelic variation in genes such as those regulating obesity, hyperlipidemia, blood pressure, and bone mineralization are associated with CAC and IMT. These data, as well as findings in separately funded ancillary studies, will allow us to examine the antecedents and prevalence of subclinical atherosclerosis in diverse populations. We will analyze the role of predisposing genetic traits in the presence of behavioral and physiologic risk factors in order to detect genotype-by-environment interactions, and to study how these differ in men and women, and in African-Americans and whites. The proposed activities will take full advantage of CARDIA's outstanding database, specimen bank, team of investigators, quality control procedures, and organizational structure. We will expand the pool of investigators contributing to design, analysis and publication activities by involving new scientists in CARDIA, and we will enhance dissemination of CARDIA data and analytic support to non-affiliated investigators. These plans will accelerate the growth of knowledge needed for designing preventive medicine policies that address the growing epidemic of obesity and reduce the public health burden of CVD, and that are tailored to specific population subgroups and settings where they will be most effective.

2003 - 8年度的年轻人研究冠状动脉风险发展（CARDIA）是一项基于人群的观察性研究，对非裔美国人和白人男性和具有多种社会经济地位的女性，始于1985 - 6年的5115名18-30岁的年轻人。在第2、5、7、10和15年的后续检查达到了高保留率，收集了大量的高质量数据，并储存的标本与心血管疾病的原因（CVD）相关，并导致了168份Peer评审出版物。 在接下来的5年中，我们将继续半年度电话联系，疾病事件监视以及分析和出版活动。我们将在我们的队列上进行20年的考试，他们将年满38-50岁。我们建议以4个主要目标重新检查至少73％的幸存者（3,650名参与者，在芝加哥学习812名参与者）： 1。确定亚临床动脉粥样硬化的发展和进展的预测因素；我们将测量风险因素水平（建立，新颖，生活方式和心理社会）和亚临床动脉粥样硬化（冠状动脉钙化[CAC]和颈动脉内膜培养基厚度[IMT]）。我们将特别注意肥胖流行病的危险因素的先例，探讨最近和远程危险因素暴露对CAC，CAC进展以及IMT的影响，并评估肥胖，糖尿病和肾脏损伤以及社会经济状况和卫生保健访问和ULIDACE和ULIDICATION等状况的作用。 2。为了阐明CVD发病机理上可能的种族差异，我们将比较与CAC发生率和患病率和IMT患病率相关的因素，跨风险性别群体；我们将探索可以解释观察到的差异的因素。 3。为了测试炎症是否在亚临床疾病之前，我们将检查炎症标记（例如C反应蛋白）与CAC和IMT的动脉粥样硬化证据之间的关联时间过程。我们还将确定炎症（例如感染）的预测指标，以及肥胖和内脏肥胖的影响。 4。通过环境相互作用在CVD发病机理中评估遗传变异和基因的作用，我们将探索它们在危险因素病因中的作用，并测试是否在基因中的等位基因变异（例如调节肥胖，高脂血症，血压，血压和骨矿化）等基因的作用是否与CAC和IMT相关联。 这些数据以及分别资助的辅助研究的发现将使我们能够检查不同人群中亚临床动脉粥样硬化的前因和患病率。我们将分析在存在行为和生理风险因素的存在下诱发遗传特征的作用，以检测逐环境的基因型相互作用，并研究男性和女性以及非裔美国人和白人的作用。 拟议的活动将充分利用Cardia出色的数据库，标本库，调查人员团队，质量控制程序和组织结构。我们将通过参与CARDIA的新科学家来扩大为设计，分析和出版活动做出贡献的研究人员，我们将增强Cardia数据的传播以及对非附属研究人员的分析支持。这些计划将加快设计预防医学政策所需的知识增长，以解决肥胖流行病的日益增长，并减轻CVD的公共卫生负担，并针对特定的人口亚组和环境量身定制，这些群体最有效。