Dual Action Inhibitors of Gyrase Beta and Histidine Kinases as Broad-Spectrum Ant

广谱抗旋酶 Beta 和组氨酸激酶双重作用抑制剂

• 批准号: 7933895
• 负责人: PETER B MADRID
• 金额: $ 98.22万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7933895
• 关键词: Adenine; American; Antibiotics; Ants; Binding; Binding Sites; Biological Assay; Biological Availability; Budgets; Categories; Development; Drug Delivery Systems; Enzymes; Equipment; Francisella tularensis; Funding; Goals; Growth; Histidine; Human; In Vitro; Intention; Lead; Libraries; Maximum Tolerated Dose; Measurement; Metabolic; Military Personnel; Minor; Modeling; Modification; Molecular Weight; Mus; National Institute of Allergy and Infectious Disease; Oral; Permeability; Pharmaceutical Chemistry; Protein Family; Protein Kinase Inhibitors; Proteins; Resistance; Resolvase; Rodent Model; Screening procedure; Signal Transduction; Specificity; Structure; Superhelical DNA; Testing; Tin; Toxic effect; Virulence; Work; analog; base; biodefense; combinatorial; counterscreen; design; in vitro activity; inhibitor/antagonist; lead series; member; pathogen; protein kinase inhibitor; protein-histidine kinase; research study; scaffold; therapeutic target; virtual

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项目成果

A high-throughput fluorescence polarization assay for inhibitors of gyrase B.

• DOI: 10.1177/1087057110392038
• 发表时间: 2011-02
• 期刊: Journal of biomolecular screening
• 作者: Glaser BT;Malerich JP;Duellman SJ;Fong J;Hutson C;Fine RM;Keblansky B;Tang MJ;Madrid PB
• 通讯作者: Madrid PB

Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities.

• DOI: 10.1016/j.bmcl.2011.08.035
• 发表时间: 2011-10-01
• 期刊: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
• 影响因子: 2.7
• 作者: Tambo-ong, Arlyn;Chopra, Sidharth;Glaser, Bryan T.;Matsuyama, Karen;Tran Tran;Madrid, Peter B.
• 通讯作者: Madrid, Peter B.