Pathways Linking Late-Life Depression to MCI & Dementia

晚年抑郁症与 MCI 的关联途径

基本信息

批准号：
7896344
负责人：
MERYL A BUTTERS
金额：
$ 33.18万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7896344
关键词：
Address Age Agreement Alzheimer&apos s Disease Alzheimer&apos s disease risk Atrophic Autopsy Award Behavior Disorders Biological Markers Brain Brain region Butter Cerebrovascular Circulation Cerebrovascular Disorders Clinic Clinical Cognition Disorders Cognitive Cognitive deficits Data Dementia Development Diagnosis Diagnostic Education Elderly Enrollment Etiology Evaluation Exhibits Frequencies Functional Magnetic Resonance Imaging Future Goals Impaired cognition Individual Injury Intervention Studies Joints Lead Link Measures Memory Memory impairment Mentored Research Scientist Development Award Methods Modeling Mood Disorders Natural History Nerve Degeneration Outcome Pathway interactions Patients Phenotype Population Preventive Process Public Health Publishing Recording of previous events Reporting Research Research Infrastructure Research Personnel Risk Risk Factors Series Structure Subgroup Testing Time Universities Vascular Dementia Visuospatial Work aged caudate nucleus cerebrovascular cognitive change cognitive function cohort depressed depression depressive symptoms executive function follow-up frontal lobe geriatric depression indexing information processing injured meetings mild neurocognitive impairment mood regulation neurobehavioral disorder neuroimaging neuropathology neuropsychological novel processing speed progressive neurodegeneration putamen white matter

项目摘要

DESCRIPTION (provided by investigator): The goal of this revised R01 application is to investigate the relationships among late-life depression (LLD), cognitive impairment and progressive neurodegeneration. The guiding hypothesis is that LLD patients have evolving cognitive impairments as a consequence of distinct underlying neuropathological changes, which frequently are expressed as Mild Cognitive Impairment (MCI). These neuropathological and cognitive changes are risk modifiers, lowering brain reserve capacity, and in turn, increasing risk of developing Alzheimer's Disease (AD). In order to pursue this goal we will enroll LLD, MCI, and normal control subjects to enrich our existing cohort (gathered through Dr. Butters' existing K01 Award (MH01684), "The Course of Cognitive Functioning in Late-Life depression" to include a total of 150 elderly, non-demented, non-depressed subjects, 60 nondepressed MCI subjects and 270 LLD subjects. Using the joint infrastructure of the University of Pittsburgh's Intervention Research Center for Late-Life Mood Disorders (MH52247) and the Alzheimer's Disease Research Center (AG05133) we will complete a detailed neurobehaviora! evaluation, including clinical, neuropsychological, neuroimaging and biological markers, using these data to evaluate the factors associated with the development of MCI or dementia. Subjects will be studied annually for at least three years, allowing us to use longitudinal data to evaluate a series of linked hypotheses that postulate the pathways by which elderly, depressed patients develop cognitive impairment, and which may lead some to develop dementia.

描述（由研究人员提供）：修订后的R01应用的目的是研究晚期抑郁症（LLD），认知障碍和进行性神经变性的关系。指导假设是，由于不同的潜在神经病理学变化，LLD患者的认知障碍会不断发展，而神经病理学的变化经常表示为轻度认知障碍（MCI）。这些神经病理学和认知变化是风险修饰，降低了大脑储备的能力，进而增加了患阿尔茨海默氏病（AD）的风险。为了实现这一目标，我们将注册LLD，MCI和正常控制受试者，以丰富我们现有的同伙（通过Butters博士的现有K01奖（MH01684）收集，“晚期抑郁症的认知功能”的过程包括150名老年人，非痴呆，未抑制的主题，使用60个不介入的MCI主题和270 lld infl infl infl inds inds in n infl inds inds inds inds inds inds inds inds infl infl and infl infl infl and infl infl infl infl and infl infl inds inds ind nld。匹兹堡晚期情绪障碍的干预研究中心（MH52247）和阿尔茨海默氏病研究中心（AG05133），我们将完成与这些因素相关的，包括临床，神经心理，神经模仿和生物学标记，包括临床，神经心理学标记，包括临床，神经心理学标志，三年，使我们能够使用纵向数据来评估一系列相关的假设，这些假设假定了老年人，抑郁症患者会出现认知障碍的途径，并可能导致一些人发展痴呆症。