SARS-CoV-2 correlates of protection in a Latino-origin population

SARS-CoV-2 与拉丁裔人群的保护相关

• 批准号: 10688353
• 负责人: James D Brien
• 金额: $ 81.04万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10688353
• 关键词: 2019-nCoV; African; American; Antibodies; Antibody titer measurement; Autoimmune Diseases; Automobile Driving; Basic Science; Biological Assay; Black American; Black race; Blood Circulation; COVID-19; COVID-19 severity; COVID-19 susceptibility; COVID-19 test; COVID-19 vaccine; Clinical; Collaborations; Communicable Diseases; Data; Dengue; Detection; Development; Disease Outcome; Dissection; Enzyme-Linked Immunosorbent Assay; Epidemiology; Etiology; FDA Emergency Use Authorization; Future; Genetic; Goals; Health Policy; Healthcare Systems; Hispanic Populations; Immune; Immune response; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunologics; Immunophenotyping; Immunosuppression; Individual; Influenza; Institutional Review Boards; Integration Host Factors; Island; Knowledge; Laboratories; Latin American; Latino; Latino Population; Lead; Malignant Neoplasms; Methods; Modeling; Molecular; Mycoplasma; Obesity; Outcome; Patients; Pattern; Pharmaceutical Preparations; Phenotype; Play; Population; Predisposition; Prevalence; Privatization; Prognosis; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Research; Research Personnel; Respiratory syncytial virus; Risk; Role; SARS-CoV-2 antibody; SARS-CoV-2 infection; Sampling; Science; Serodiagnoses; Serology; Serology test; Seroprevalences; Severities; Social Environment; Source; Speech; T-Lymphocyte; Technology; Testing; Time; Trust; Uncertainty; Vaccines; Virus; Vulnerable Populations; Washington; World Health Organization; ZIKA; biobank; chikungunya; clinical diagnostics; cohort; comorbidity; cytokine; diagnostic platform; follow-up; interest; medically underserved; member; neutralizing antibody; news; novel coronavirus; pandemic disease; pathogen; programs; racial disparity; recruit; repository; severe COVID-19; social group; social vulnerability; socioeconomics; study population; transmission process; vaccine candidate; volunteer

Summary This is an initiative in support of the SARS-CoV-2 Serological Sciences, Sero Network. The rapid circulation and spread of this virus lead to a significant impact to the healthcare systems with an important societal disruption. Particularly susceptible has been the Black and Latino American origin population. In addition to the demographic and social environment, it is no know if the genetic background plays a predominant role in that outcome. In 42 states plus Washington D.C., Hispanics/Latinos make up a greater share of confirmed cases than their share of the population. In eight states, it's more than four times greater. A great deal of effort has been deployed at a global level to contain, mitigate, and to understand the circulation, transmission, and immune response among others to SARS-CoV-2. However, there is a huge lack of knowledge particularly in the dynamic of the immune response to this virus. One additional problem is that the correlation between the antibodies titers and their neutralizing capabilities is poorly understood. Due to it, is difficult to anticipate the level of protection of an individual having specific antibodies against SARS-CoV-2. So far, the pandemic metrics, predictions, forecast models, and so on have been relying on molecular and serological assays in an overwhelming manner. The contribution of the T cells, a key player in the immune response has not been even mentioned by the organizations providing advice and guidance on the management of the pandemic. Understanding the mechanisms driving the serological, humoral, and cellular immune responses associated with the host genetic and how they correlate with protection against SARS-CoV-2 is mandatory. We will implement this SeroNet project in a Latino-African background population to determine the real seroprevalence to SARS- CoV-2. Also, we aim to study the contribution of the genetic background (HLA characterization) to the disease outcome and as susceptibility to worst clinical presentations. I order to accomplish our goals we will look in detail to the antibodies neutralizing activity, T cells immunophenotypes, cytokine profile and will integrate that data with the genetic characterization. Particular vulnerable population (individuals with comorbidities such as autoimmune disease, immunosuppression, and obesity, medically underserved, and cancer populations) will be included in the cohort). Our results will be compared with results obtained by other group members of the SARS-CoV-2 Sero Network.

概括 这是一项支持 SARS-CoV-2 血清学科学、血清网络的举措。 这种病毒的快速传播和传播对医疗保健系统产生了重大影响 严重的社会混乱。特别容易受到影响的是黑人和拉丁美洲裔人口。 除了人口和社会环境之外，尚不清楚遗传背景是否也起到了一定的作用。 并在该结果中发挥主导作用。在 42 个州以及华盛顿特区，西班牙裔/拉丁裔所占比例更大 确诊病例数高于其在人口中所占的比例。在八个州，这个数字是四倍多。一个伟大的 全球范围内已投入大量努力来遏制、缓解和了解病毒的传播， SARS-CoV-2 的传播和免疫反应等。但知识却存在巨大的匮乏 特别是针对这种病毒的免疫反应的动态。另一个问题是相关性 人们对抗体滴度与其中和能力之间的关系知之甚少。正因为如此，很难 预测具有 SARS-CoV-2 特异性抗体的个体的保护水平。到目前为止， 大流行指标、预测、预测模型等一直依赖于分子和血清学 以压倒性的方式进行分析。 T 细胞是免疫反应的关键参与者，其贡献已 就管理问题提供建议和指导的组织甚至没有提及 大流行。 了解驱动与相关的血清学、体液和细胞免疫反应的机制 宿主遗传及其与 SARS-CoV-2 防护的相关性是强制性的。我们将实施 这个 SeroNet 项目在拉丁美洲和非洲背景人群中进行，旨在确定 SARS 的真实血清流行率 冠状病毒-2。此外，我们的目标是研究遗传背景（HLA 特征）对疾病的影响 结果以及对最坏临床表现的易感性。为了实现我们的目标，我们将详细研究 抗体中和活性、T 细胞免疫表型、细胞因子谱，并将这些数据与 遗传特征。特殊弱势群体（患有自身免疫性疾病等合并症的人） 疾病、免疫抑制和肥胖、医疗服务不足和癌症人群）将被纳入 队列）。我们的结果将与 SARS-CoV-2 血清组其他成员获得的结果进行比较 网络。