Evaluating the efficacy of annual CHTC retesting among male couples at high risk of HIV infection

评估 HIV 感染高危男性夫妇每年进行 CHTC 重新检测的效果

• 批准号: 10700394
• 负责人: Tyrel J Starks
• 金额: $ 10.76万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10700394
• 关键词: 4-hydroxybutyric acid; AIDS prevention; Accounting; Address; Adherence; Age; Agreement; Amphetamines; Appointment; Bisexual; COVID-19; Cannabis; Chlamydia Infections; Cocaine; Communication; Consent; Counseling; Couples; Data; Drug usage; Enrollment; Feedback; Gays; Gonorrhea; HIV; HIV Infections; HIV Seronegativity; HIV Seropositivity; Human immunodeficiency virus test; Individual; Infection; Intervention; Investments; Ketamine; Link; Measures; Mediating; Mediator; Modeling; Nature; Nitrates; Outcome; Parents; Participant; Population; Prevention; Prevention strategy; Protocols documentation; Public Health; Randomized; Recommendation; Recording of previous events; Reporting; Research; Rest; Risk; Risk Behaviors; Sampling; Syphilis; Testing; Time; Training; United States National Institutes of Health; aged; binge drinking; condomless anal sex; coping; design; ecstasy; efficacy evaluation; efficacy testing; emerging adult; follow up assessment; follow-up; high risk; implementation research; intervention effect; male couples; men; men who have sex with men; motivational enhancement therapy; post intervention; pre-exposure prophylaxis; response; sex; sexual HIV transmission; sexual minority men; skills; substance use; theories; transmission process; uptake

Project Summary Sexual minority men (SMM), including gay, bisexual, and other men who have sex with men, account for 69% of new HIV infections in the US. Primary partnerships have been linked to up to as many as 68% of new HIV infections among SMM. This rate is highest among emerging adult SMM (aged 18-29), where estimates suggest 79% to 84% of HIV infections are transmitted by primary partners. In response to the concerns posed by primary partner transmission, couples HIV testing and counseling (CHTC) has been acknowledged as an established HIV prevention strategy. During CHTC, couples complete HIV testing and prevention planning together. Current CHTC guidance includes the recommendation that all couples routinely retest every 6 to 12 months. Despite the standard nature of this retesting recommendation, no study has empirically evaluated the effects of CHTC retesting. This competitive revision capitalizes on NIH investment in the parent study (DA050508) to obtain the first outcomes data on annual CHTC retesting. DA050508 is currently enrolling 240 male couples living in the US in which at least one partner: is age 17 to 29; is HIV-negative; and reports recent (past 30 days) drug use (e.g., cannabis, cocaine/crack, amphetamines, ecstasy, gamma hydroxybutyric acid, ketamine, or nitrates), and recent (past 3 months) sexual HIV transmission risk behavior. As part of their participation in DA050508, all couples complete a CHTC session after baseline. They subsequently complete follow-up assessments at 3, 6, 9, and 12-months post- baseline. The purpose of this revision is to evaluate the benefits associated with CHTC resting. After their 12- month follow-up, those participants who remain in the same relationship they were in at the time of their baseline will be offered the opportunity to continue in the components proposed in this revision. Those who consent will be randomized to either complete a second session of CHTC or to a comparison condition in which both partners receive a routine individual HIV test. HIV positive partners in serodiscordant couples randomized to the control condition will receive information about ART adherence and U=U. Given potential attrition and rates of relationship dissolution, we anticipate randomizing 200 couples (80% of the original sample). Follow-up assessments will be conducted 3 and 6 months after retesting (15 and 18 months after the participants’ original baseline appointment).

项目概要 性少数男性 (SMM)，包括同性恋、双性恋和其他男男性行为者，账户 美国 69% 的新发艾滋病毒感染者与多达 68% 的主要伴侣有关。 SMM 中的新 HIV 感染率在新兴成人 SMM（18-29 岁）中最高，其中 据估计，79% 至 84% 的艾滋病毒感染是由主要伴侣传播的。 主要伴侣传播、夫妻艾滋病毒检测和咨询（CHTC）引起的担忧 在 CHTC 期间，夫妇完成艾滋病毒检测并被认为是一项既定的艾滋病毒预防策略。 共同预防规划。 当前的 CHTC 指南包括建议所有夫妇每 6 至 12 点例行重新测试一次 尽管这一重新测试建议具有标准性质，但没有研究对这一结果进行实证评估。 CHTC 重新测试的影响 该竞争性修订利用了 NIH 对母研究的投资。 （DA050508）获得年度 CHTC 重新测试的第一个结果数据。 DA050508 目前正在招募 240 名居住在美国的男性夫妇，其中至少一名伴侣： 年龄 17 至 29 岁；HIV 呈阴性；并且报告最近（过去 30 天）吸毒（例如大麻、可卡因/快克、 安非他明、摇头丸、γ-羟基丁酸、氯胺酮或硝酸盐）以及最近（过去 3 个月）的性行为 作为参与 DA050508 的一部分，所有夫妇都完成了 CHTC。 他们随后在基线后 3、6、9 和 12 个月完成后续评估。 基线。 本次修订的目的是评估 12 岁后 CHTC 休息的相关益处。 一个月的随访中，那些仍保持与他们当时的关系相同的参与者 基线将有机会继续在本次修订中提议的组成部分中。 同意将被随机分配以完成 CHTC 的第二次会议或在 血清不一致的夫妇双方都接受常规的艾滋病毒阳性伴侣检测。 随机分配到对照条件将收到有关 ART 依从性和 U=U 给定潜力的信息。 考虑到流失率和关系解除率，我们预计随机抽取 200 对夫妇（原始夫妇的 80%） 后续评估将在重新测试后 3 个月和 6 个月（测试后 15 个月和 18 个月）进行。 参与者的原始基线预约）。

项目成果

A full-factorial randomized controlled trial of adjunct couples HIV testing and counseling components addressing drug use and communication skills among sexual minority male couples.

一项针对辅助夫妇艾滋病毒检测和咨询内容的全因素随机对照试验，旨在解决性少数男性夫妇的吸毒和沟通技巧问题。

• 发表时间: 2021-11-24
• 影响因子: 4.5
• 作者: Starks, Tyrel J;D Kyre, Kory;B Cowles, Christine;Castiblanco, Juan;Washington, Catherine;N Parker, Jayelin;M Kahle, Erin;Stephenson, Rob
• 通讯作者: Stephenson, Rob

Correlates of Mpox Vaccination among Sexual Minority Men in the United States: Sexual Behavior, Substance Use, and Main Partner Relationships.

美国性少数男性 Mpox 疫苗接种的相关性：性行为、药物使用和主要伴侣关系。

• 发表时间: 2023
• 影响因子: 3.6
• 作者: Starks, Tyrel J;Scales, David;Castiblanco, Juan;Gorman, Jack;Cain, Demetria
• 通讯作者: Cain, Demetria