High Framerate Plane-Wave Variance of Acceleration and Vector Flow Imaging for the Characterization of Atherosclerotic Plaque Morphology and Assessment of Vascular Hemodynamics

高帧率平面波加速度方差和矢量流成像用于动脉粥样硬化斑块形态的表征和血管血流动力学的评估

• 批准号: 10700833
• 负责人: Keerthi Surej Anand
• 金额: $ 4.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10700833
• 关键词: 3-Dimensional; Acceleration; Acoustics; Arterial Fatty Streak; Biopsy; Blood Vessels; Blood flow; Calcium; Cardiac; Cardiovascular Diagnostic Techniques; Cardiovascular Diseases; Carotid Arteries; Carotid Endarterectomy; Cause of Death; Characteristics; Clinical; Code; Collagen; Computer Models; Data; Data Collection; Detection; Development; Diagnostic; Diagnostic Imaging; Disease Progression; Doppler Ultrasound; Environment; Future; Geometry; Goals; Growth; Heating; Hemorrhage; Histologic; Human; Image; Imaging Device; Ionizing radiation; Ischemic Stroke; Lipids; Liquid substance; Location; Measurement; Measures; Mechanics; Methods; Modeling; Monitor; Morphologic artifacts; Morphology; Motion; Names; Necrosis; Noise; Operative Surgical Procedures; Outcome; Patients; Pattern; Phenotype; Physicians; Physics; Physiologic pulse; Physiological; Play; Predisposition; Procedures; Property; Public Health; Radiation; Resolution; Risk; Risk Assessment; Rupture; Scheme; Sensitivity and Specificity; Signal Transduction; Solid; Stenosis; Stress; Stroke prevention; Structure; Techniques; Technology; Time; Tissue imaging; Tissues; Translating; Ultrasonography; Validation; Visualization; Work; atherosclerotic plaque rupture; clinical decision-making; combat; cost; design; diagnosis standard; early screening; elastography; feature detection; hemodynamics; holistic approach; image processing; imaging approach; improved; in vivo; logarithm; mechanical properties; meetings; minimally invasive; novel; operation; preclinical study; risk prediction; screening; shear stress; signal processing; simulation; spatiotemporal; stroke risk; success; tool; transmission process; ultrasound; vector

PROJECT SUMMARY The need for minimally invasive methods for screening early predictors of ischemic stroke are required to combat the increase in cardiovascular disease cases while reducing number of unnecessary carotid endarterectomies, which are invasive but preventative procedures to remove plaques. The current gold-standard for diagnosis, duplex ultrasound, is often used to detect heavily occluded vasculature, but simply noting the degree of stenosis is an insufficient measure of plaque rupture vulnerability. Acoustic Radiation Force Impulse (ARFI) ultrasound technique recently emerged as a potential method to separate vulnerable from stable plaques through delineation of plaque components. However, as the technique relies on emission of high intensity focused acoustic pulses, although nondestructive, the potential for tissue heating limits extended uses, while the long period of data collection increases opportunities for motion artifacts to corrupt data collection and physiological interpretation of results. The use of a new ultrafast ARFI imaging sequence to evaluate both plaque structure and surrounding hemodynamics may provide significant advancement in reducing acquisition time, reducing acoustic heating, and improving risk prediction. There exists overwhelming evidence that mechanics of plaque growth and rupture are governed by shear forces acting on the vessel walls. Monitoring the dynamics changes in shear stress in addition to more efficiently detecting plaque composition may prove a novel avenue for discerning at risk patients with vulnerable atherosclerotic plaques vs those with stable plaque phenotypes. We propose to further develop and characterize ultrasound parallel transmit sequences to image tissue in rapid succession and additionally detect multi directional blood flow around the vasculature. Combining the ARFI elastography, high framerate imaging, and flow information allows a real-time realizable assessment of the plaque environment throughout the entire cardiac cycle. Therefore, meeting the aims of the study will further develop diagnostic imaging tools for future stroke risk assessment.

项目概要 需要采用微创方法来筛查缺血性中风的早期预测因素 对抗心血管疾病病例的增加，同时减少不必要的颈动脉数量 动脉内膜切除术，这是一种侵入性但预防性的去除斑块的手术。目前的黄金标准 对于诊断，双功超声通常用于检测严重闭塞的脉管系统，但只需注意 狭窄程度不足以衡量斑块破裂的脆弱性。声辐射力脉冲 (ARFI) 超声技术最近成为区分脆弱斑块和稳定斑块的潜在方法 通过描绘斑块成分。然而，由于该技术依赖于高强度的发射 聚焦声脉冲虽然非破坏性，但组织加热的潜力限制了扩展用途，而 长时间的数据收集增加了运动伪影破坏数据收集和的机会 结果的生理解释。使用新的超快 ARFI 成像序列来评估两者 斑块结构和周围的血流动力学可能会在减少 采集时间、减少声热并改进风险预测。存在压倒性的 有证据表明斑块生长和破裂的机制是由作用在血管壁上的剪切力控制的。 除了更有效地检测牙菌斑成分之外，还监测剪切应力的动态变化 可能被证明是一种新的途径，可用于辨别具有易损动脉粥样硬化斑块的高危患者与患有动脉粥样硬化斑块的患者 稳定的斑块表型。我们建议进一步开发和表征超声并行传输 序列快速连续地对组织进行成像，并另外检测组织周围的多向血流 脉管系统。结合 ARFI 弹性成像、高帧率成像和血流信息，可以实现实时 对整个心动周期中的斑块环境进行可实现的评估。因此，满足 该研究的目的是进一步开发用于未来中风风险评估的诊断成像工具。