Childhood adversity and substance use: Integrating laboratory and ecological approaches to understand the role of affect

童年逆境和物质使用：结合实验室和生态方法来理解情感的作用

基本信息

批准号：
10684168
负责人：
Shaquanna A. Brown
金额：
$ 18.75万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10684168
关键词：
Adolescence Adolescent Affect Affective Age Alcohols Attention Behavior Behavioral Cannabis Child Child Traumatic Stress Clinical Collection Data Data Analytics Data Reporting Development Dimensions Distress Ecological momentary assessment Educational workshop Eligibility Determination Emotional Emotions Environment Equilibrium Exhibits Exposure to Face Fostering Funding Future Galvanic Skin Response Genetic Complementation Test Goals Health Care Costs Heart Rate Hospitals Individual Institution Intervention K-Series Research Career Programs Laboratories Link Longitudinal Studies Measurement Mediating Mentors Mentorship Methodology Methods Modeling Morbidity - disease rate Mydriasis National Institute of Drug Abuse Neurobiology Nicotine Participant Pathway interactions Patient Self-Report Pattern Persons Physiological Play Process Psychologist Psychophysiology Public Health Questionnaires Recording of previous events Reporting Research Research Design Research Methodology Research Personnel Research Priority Research Support Risk Risk Factors Role Severities Standardization Stimulus Strategic Planning Substance Use Disorder Substance abuse problem Task Performances Techniques Testing Time Training Training Support United States Universities Visit adolescent substance use advanced analytics adverse childhood events biobehavior career development childhood adversity design distress tolerance early life stress economic cost emerging adult experience follow-up improved improved outcome indexing innovation longitudinal design medical schools modifiable risk mortality negative affect programs psychologic recruit resilience response screening social substance use symposium twelfth grade visual tracking

项目摘要

PROJECT SUMMARY/ABSTRACT By 12th grade, over 50% of adolescents in the United States endorse lifetime substance use. Childhood adversity is a prevalent and robust risk factor for adolescent substance use. Approximately 54% of adolescents report adverse childhood experiences (ACEs), making them over 1.5 times more likely to use substances. Yet, many adolescents with ACEs deny substance use engagement, implying the existence of modifiable risk factors. Using an integrative model of ecological and laboratory approaches, the proposed study examines the role of affect in the link between ACEs and adolescent substance use. Candidate: The candidate is a clinical child psychologist with a long-standing commitment to studying risk and resilience associated with early life stress. Her prior research has focused on elucidating mechanisms that contribute to substance use in emerging adults with ACEs. She is applying for a five-year K08 Career Development Award to expand her expertise and support her training, mentorship, and research in adolescent substance use. Training: The proposed training plan includes formal workshops, seminars, conferences, directed readings, and mentored experiences that will advance her trajectory toward research independence by fostering new expertise in: (1) highly rigorous and cutting edge laboratory-based physiological techniques, including eye tracking, pupil dilation, galvanic skin response, and heart rate measurement, (2) the collection, management, and analysis of ecological momentary assessment (EMA) data, (3) advanced analytical approaches to integrate multimethod research designs, (4) the design and implementation of adolescent substance use research, and (5) enhanced professional development. The candidate is institutionally supported by The Miriam Hospital and The Warren Alpert Medical School of Brown University. Mentoring: Five well-established researchers serve as mentors on this proposal. Each mentor offers complementary expertise consistent with the study’s aims and training objectives, including advanced data analytic techniques, EMA, childhood traumatic stress, laboratory-based bio-behavioral assessment, and adolescent substance use research. Research: The proposed study will recruit adolescent participants (N=100, ages 13-18) from an active longitudinal study (R01HD104187). Using EMA, eye tracking, behavioral task performance, and traditional self-report data, the aims of the proposal are to: examine the indirect effects of ACEs on substance use via affect balance (Aim 1), tolerance of affective distress (Aim 2), and attention/reactivity to affective stimuli (Aim 3).

项目概要/摘要到了 12 年级，超过 50% 的美国青少年支持在童年时期使用药物。逆境是大约 54% 的青少年吸毒的一个普遍且强烈的危险因素。报告不良童年经历 (ACE)，使他们使用药物的可能性增加 1.5 倍以上。许多患有 ACE 的青少年否认参与药物使用，这意味着存在可改变的风险拟议的研究使用生态学和实验室方法的综合模型来检验。情感在 ACE 和青少年物质使用之间的联系中的作用：候选人是一名临床医生。儿童心理学家，长期致力于研究与早期生活相关的风险和复原力她之前的研究重点是阐明导致物质使用的机制。她正在申请五年期 K08 职业发展奖，以拓展自己的能力。专业知识并支持她在青少年药物使用培训方面的培训、指导和研究。拟议的培训计划包括正式讲习班、研讨会、会议、定向阅读和指导通过培养以下方面的新专业知识，这些经验将推动她走向独立研究的轨道：(1) 高度严格和尖端的基于实验室的生理技术，包括眼球追踪、瞳孔扩张、皮肤电反应和心率测量，(2) 收集、管理和分析生态瞬时评估（EMA）数据，（3）集成多种方法的先进分析方法研究设计，(4) 青少年物质使用研究的设计和实施，以及 (5) 加强候选人得到米里亚姆医院和沃伦的机构支持。布朗大学阿尔珀特医学院的导师：五位知名研究人员担任导师。该提案的每位导师都提供与研究目标和培训相一致的补充专业知识。目标，包括先进的数据分析技术、EMA、儿童创伤应激、基于实验室的生物行为评估和青少年物质使用研究：拟议的研究将。从一项纵向主动研究 (R01HD104187) 中招募青少年参与者（N=100，年龄 13-18）。 EMA、眼动追踪、行为任务表现和传统的自我报告数据，该提案的目的是目的：通过情感平衡（目标 1）、情感耐受性检查 ACE 对物质使用的间接影响痛苦（目标 2），以及对情感刺激的注意力/反应（目标 3）。