Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions

肺癌预防、早期检测和治疗干预的比较模型

基本信息

批准号：
10687334
负责人：
THEODORE R HOLFORD
金额：
$ 4.26万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-08 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10687334
关键词：
Accounting Adopted Adoption Advisory Committees American College of Radiology Biological Markers Cancer Burden Cancer Etiology Cancer Intervention and Surveillance Modeling Network Cessation of life Cigarette Data Decision Making Development Early Diagnosis Early treatment Effectiveness Electronic cigarette Future Genetic Geographic Locations Histology Immunotherapy Incidence Individual Intervention Joints Lung Malignant neoplasm of lung Modeling Outcome Policies Population Population Research Precision therapeutics Prevalence Preventive service Process Recording of previous events Registries Research Research Personnel Resources Risk Risk Factors Schedule Screening Result Smoking Smoking History Source Taxation Taxes Tobacco Tobacco 21 policies United States Work budget impact cancer recurrence cancer survival cancer therapy comparative cost effectiveness cost-effectiveness evaluation electronic cigarette use fight against health warning implementation barriers innovation low and middle-income countries low dose computed tomography lung basal segment lung cancer prevention lung cancer screening mortality personalized approach population health programs public policy on tobacco screening screening guidelines smoking cessation smoking initiation sociodemographic factors targeted treatment tobacco control tobacco products tobacco screening tool working group

项目摘要

Project Summary Abstract Lung cancer remains the leading cause of cancer related mortality in the US and globally— responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we have contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to continue declining. However, lung cancer is still expected to result in over 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reduce the lung cancer burden in the US. Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there are concerns that the gains achieved in the fight against smoking could reverse. We propose to continue our work and extend our models to assess the impact of 1) future tobacco control interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer screening and other emerging early detection strategies, 3) innovations in lung cancer treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall mortality in the US and globally.

项目概要摘要肺癌仍然是美国和全球癌症相关死亡的主要原因—— 作为癌症的合作研究人员，每年造成约 180 万人死亡。干预和监测建模网络 (CISNET) 肺部工作组 (LWG)，我们为美国减少肺癌国家战略的制定做出了贡献通过量化烟草控制对吸烟、肺癌和整体的影响来减轻负担死亡率，并通过评估肺癌筛查对人群的益处和危害美国。由于美国吸烟人数持续减少，肺癌死亡率预计将下降。然而，预计肺癌仍将导致超过 400 万人死亡。因此，未来 50 年，除了烟草控制工作外，还应重点关注早期发现和预防。治疗干预对于进一步减轻美国肺癌负担至关重要。此外，随着电子烟（e-cigs）等新型烟草产品越来越受欢迎，我们担心在打击吸烟方面取得的成果可能会逆转。继续我们的工作并扩展我们的模型以评估 1) 未来烟草控制的影响对不断变化的烟草市场格局进行干预，2) 改善肺癌筛查和其他新兴的早期检测策略，3）肺癌方面的创新治疗，更重要的是，4）它们对肺癌发病率和整体的协同作用美国和全球的死亡率。