Aging, Western Diet and Physiological Dysfunction: Exercise and Inflammation

衰老、西方饮食和生理功能障碍：运动和炎症

• 批准号: 7787200
• 负责人: Lisa A Lesniewski
• 金额: $ 12.5万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-07-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7787200
• 关键词: Adipocytes; Adipose tissue; Adult; Adverse effects; Aerobic Exercise; Age; Aging; Animals; Anti-Inflammatory Agents; Area; Atherosclerosis; Award; Behavior; Biological Availability; Blood Vessels; Cardiovascular Diseases; Cells; Chronic; Clinical Trials; Colorado; Complement; Consult; Consumption; Development; Development Plans; Diabetes Mellitus; Diet; Disease; Doctor of Philosophy; Elderly; Environment; Environmental Risk Factor; Exercise; Exposure to; Fatty acid glycerol esters; Functional disorder; Funding; Genes; Glucose; Goals; Human; Infiltration; Inflammation; Inflammatory; Ingestion; Insulin; Insulin Resistance; Journals; Life Style; Measurement; Measures; Mediating; Mentors; Metabolic; Molecular; Mononuclear; Mus; Nitric Oxide; Oral; Oxidative Stress; Phenotype; Physiological; Physiology; Predisposition; Prevention; Process; Research; Research Personnel; Research Project Grants; Resistance; Risk; Running; Scientist; Series; Sodium Salicylate; Structure; System; Testing; Tissues; Training; Training Activity; Universities; Vascular Endothelium; Visceral; Work; base; career; career development; cytokine; disorder risk; insight; insulin sensitivity; insulin signaling; insulin tolerance; meetings; middle age; novel; obesity risk; prevent; programs; protective effect; public health relevance; response; seal; skills; vascular endothelial dysfunction

DESCRIPTION (provided by applicant): The candidate, Lisa A. Lesniewski Ph.D., is a physiologist in the Department of Integrative Physiology at the University of Colorado at Boulder. Dr. Lesniewski's research focuses on the mechanisms mediating vascular and metabolic dysfunction with aging and how habitual aerobic exercise can preserve physiological function with aging. Her immediate goal is to acquire new research and professional skills that will help her to achieve her long-term career goal of developing a successful independent, extramurally-funded research program on the prevention and treatment of vascular and metabolic aging. The proposed KO1 award will provide Dr. Lesniewski the necessary support to achieve this goal. CAREER DEVELOPMENT PLAN. Dr. Lesniewski's research career development training activities will consist of: 1) acquiring new research skills associated with and complementary to the proposed research plan; and 2) structured activities including formal course-work, attendance and presentations at weekly journal clubs, university seminar series and scientific meetings, and regular interactions with her mentoring team. ENVIRONMENT. The environment for Dr. Lesniewski's training should be outstanding. The sponsor, Dr. Douglas Seals, is a well-established extramurally-funded scientist with a strong record of successful mentoring in biomedical aging research. He is complemented by a group of consulting mentors that consist of internationally- recognized investigators, each providing specific expertise in a key area of Dr. Lesniewski's research project and overall training plan. RESEARCH. The aims of the research project are to establish if aging increases susceptibility to the deleterious effects of a high fat, or Western diet (WD) by exacerbating chronic low grade inflammation and to determine if habitual exercise can prevent the deleterious effects of WD on vascular and metabolic function by reducing inflammation. The proposed research will use an "integrative" (system to gene) approach in young, middle-aged, and older mice to identify the cellular and molecular mechanisms by which WD causes inflammation-associated endothelial and metabolic dysfunction with aging and regular exercise exerts protective effects. The results should provide clinically important information regarding: 1) the influence of aging in altering vulnerability to a commonly encountered factor, WD and 2) the mechanisms by which WD causes and habitual exercise prevents these deleterious effects. PUBLIC HEALTH RELEVANCE: Advancing age and consumption of a WD are associated with vascular and metabolic dysfunction and disease. However, it is unknown if the adverse effects of WD become greater with aging, the mechanisms by which this occurs, and if these effects can be prevented by habitual aerobic exercise.

描述（由申请人提供）：候选人Lisa A. Lesniewski博士是科罗拉多大学博尔德分校综合生理学系的生理学家。 Lesniewski博士的研究重点是介导血管和代谢功能障碍的机制，以及习惯性有氧运动如何通过衰老来保留生理功能。她的近期目标是获得新的研究和专业技能，这将有助于她实现自己的长期职业目标，以制定一项成功的独立，外部资助的研究计划，以预防和治疗血管和代谢衰老。拟议的KO1奖将为Lesniewski博士提供实现这一目标的必要支持。职业发展计划。 Lesniewski博士的研究职业发展培训活动将包括：1）获得与拟议的研究计划相关和补充的新研究技能； 2）结构化活动，包括在每周期刊俱乐部举行的正式课程，出勤和演讲，大学研讨会系列和科学会议以及与她的指导团队的定期互动。环境。 Lesniewski博士培训的环境应该是杰出的。赞助商道格拉斯·海·海斯（Douglas Seals）博士是一位知名的外部资助的科学家，在生物医学衰老研究中成功指导了成功的记录。他得到了一组由国际认可的调查人员组成的咨询导师的补充，每个研究人员都在Lesniewski博士的研究项目和整体培训计划的关键领域中提供了特定的专业知识。研究。研究项目的目的是确定衰老是否通过加剧慢性低年级炎症来提高对高脂或西方饮食（WD）有害影响的敏感性，并确定习惯运动是否可以通过减少炎症来防止WD对血管和代谢功能的有害影响。拟议的研究将在年轻，中年和老年小鼠中使用“综合”（基因的系统）方法来识别WD引起与炎症相关的内皮和代谢功能障碍的细胞和分子机制，并具有衰老，并定期运动施加保护作用。结果应提供有关以下方面的临床重要信息：1）衰老在改变脆弱性变为常见因素的影响，WD和2）WD引起和习惯运动的机制阻止了这些有害影响。 公共卫生相关性：促进WD的年龄和消费与血管和代谢功能障碍和疾病有关。但是，未知WD的不良影响是否随着衰老而变得更大，发生的机制以及是否可以通过习惯性有氧运动来预防这些影响。