The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence

睡眠在不良童年经历、心理健康症状和青春期持续/复发性疼痛之间关系中的作用

• 批准号: 10676403
• 负责人: Thea Senger-Carpenter
• 金额: $ 4.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-28 至 2025-06-27
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676403
• 关键词: Abdominal Pain; Adolescence; Adolescent; Affect; Age; American; Anxiety; Brain; Buffers; Camellia sinensis; Community Health; Data; Data Analyses; Development; Early Intervention; Equation; Ethnic Origin; Exposure to; Fellowship; Female; Funding; Future; Goals; Headache; Health; Inequity; Intervention; Longitudinal Studies; Maintenance; Manuscripts; Mediation; Mental Depression; Mental Health; Mentorship; Methodology; Michigan; Modeling; National Institute of Nursing Research; Nurses; Outcome; Pain; Pathway interactions; Persistent pain; Personal Satisfaction; Productivity; Psyche structure; Publications; Race; Recurrent pain; Research; Research Project Grants; Risk; Risk Factors; Role; School Nursing; Scientist; Sleep; Sleep Deprivation; Socioeconomic Status; Strategic Planning; Symptoms; Teenagers; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Youth; advanced analytics; adverse childhood events; anxiety symptoms; associated symptom; biopsychosocial; career; career networking; cognitive development; cost; depressive symptoms; early adolescence; ethnic minority; experience; hands on research; health care service utilization; health equity; health inequalities; insight; low socioeconomic status; pain symptom; physical conditioning; physical symptom; poor sleep; population health; prevent; prospective; racial minority; reduce symptoms; sex; skills; sleep health; socioeconomics; theories; vulnerable adolescent; young adult

PROJECT SUMMARY The goal of this fellowship is to prepare the applicant, Thea Senger-Carpenter, as a nurse-scientist studying relationships among adolescent sleep, adverse childhood experiences (ACEs), and associated symptoms and outcomes. To that end, the proposed fellowship consists of two complementary components: (1) a training plan comprising formal training, mentorship, hands-on research, manuscript publication, and professional development activities and (2) a research project that will further our understanding of how sleep affects the relationships among ACEs, mental health symptoms and persistent or recurrent pain (PRP) during adolescence. The applicant will be supported by a strong mentorship team with sponsors at the University of Michigan School of Nursing and Yale School of Nursing. Together, the mentorship team provides expertise in adolescent sleep, pain and associated symptoms, and ACE exposure. The training program will help the applicant develop: a) expertise in adolescent sleep, PRP, and the sequelae of ACE exposure, b) methodological skills in longitudinal, multivariate data analysis and c) engage in the dissemination of research findings and professional networking activities. Sleep deficiency affects up to two-thirds of American adolescents and is a risk factor for PRP, anxiety, and depression. ACE exposure is similarly prevalent, affecting around half of U.S. teens, and has been associated with both PRP and mental health symptoms. Importantly, sleep deficiency may moderate the effect of ACE exposure on other health outcomes. However, little is known about how sleep deficiency impacts the relationships among ACE exposure, mental health symptoms, and PRP across adolescence nor how these relationships differ by race, ethnicity, socioeconomic status (SES), and sex. Thus, the aims of the proposed project are 1) to determine whether and how sleep deficiency moderates the indirect effect of ACEs on PRP through mental health symptoms and 2) to describe how these relationships differ by race, ethnicity, SES, and sex. All aims will be investigated using the Adolescent Brain Cognitive Development Study, an ongoing NIH- funded longitudinal study of youth development in the United States. This proposed project integrates the research lenses of health equity and population and community health outlined in the National Institute of Nursing Research's strategic plan. By identifying sleep as a modifiable target for intervention, our findings have the potential to reduce the symptom burden of adolescents exposed to ACEs and mitigate racial, ethnic, socioeconomic, and sex-based inequities in health outcomes.

项目概要 该奖学金的目标是让申请人 Thea Senger-Carpenter 做好准备，成为一名护士科学家，学习 青少年睡眠、不良童年经历 (ACE) 和相关症状之间的关系 结果。为此，拟议的研究金由两个互补的部分组成：(1) 培训计划 包括正式培训、指导、实践研究、手稿出版和专业 开发活动和（2）一个研究项目，该项目将进一步了解睡眠如何影响 ACE、心理健康症状和持续性或复发性疼痛 (PRP) 之间的关系 青春期。申请人将得到强大的导师团队和大学赞助商的支持 密歇根护理学院和耶鲁护理学院。指导团队共同提供以下方面的专业知识 青少年睡眠、疼痛和相关症状以及 ACE 暴露。该培训计划将帮助 申请人培养：a) 青少年睡眠、PRP 和 ACE 暴露后遗症方面的专业知识，b) 纵向、多变量数据分析的方法论技能，以及 c) 参与研究传播 调查结果和专业网络活动。 睡眠不足影响了多达三分之二的美国青少年，并且是 PRP、焦虑症和糖尿病的危险因素 沮丧。 ACE 暴露同样普遍，影响了大约一半的美国青少年，并且与 同时患有 PRP 和心理健康症状。重要的是，睡眠不足可能会减弱 ACE 的作用 暴露于其他健康结果。然而，人们对于睡眠不足如何影响睡眠知之甚少。 整个青春期 ACE 暴露、心理健康症状和 PRP 之间的关系以及这些因素如何 关系因种族、民族、社会经济地位 (SES) 和性别而异。因此，拟议的目标 项目是 1) 确定睡眠不足是否以及如何调节 ACE 对 PRP 的间接影响 通过心理健康症状 2) 描述这些关系如何因种族、民族、社会经济地位和 性别。所有目标都将通过青少年大脑认知发展研究进行调查，这是一项正在进行的 NIH- 资助了美国青年发展的纵向研究。 该拟议项目整合了健康公平以及人口和社区健康的研究视角 国家护理研究所的战略计划中概述了这一点。通过将睡眠视为可改变的 作为干预目标，我们的研究结果有可能减少暴露于以下环境的青少年的症状负担 ACE 并减轻健康结果中的种族、民族、社会经济和性别不平等。