Bioengineering Center for Regeneration and Formation of Tissues (SC BioCRAFT)

组织再生与形成生物工程中心 (SC BioCRAFT)

基本信息

批准号：
10670143
负责人：
Naren R Vyavahare
金额：
$ 114.29万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670143
关键词：
Advisory Committees Affect Allografting Area Autologous Award Basic Science Behavior Biocompatible Materials Biomaterials Research Biomedical Engineering Bone Tissue Capital Cardiovascular Diseases Cardiovascular system Centers of Research Excellence Clinical Collaborations Core Facility Data Development Developmental Biology Diabetes Mellitus Disadvantaged Disease Economics Endowment Engineering Ensure Equipment Evaluation Extramural Activities Faculty Fees Fostering Funding Future Goals Growth and Development function Health Image In Situ Individual Infrastructure Institution Knowledge Lead Leadership Learning Life Medical Medicine Mentors Methods Mission Morbidity - disease rate National Institute of General Medical Sciences Natural regeneration Nature Obesity Organ failure Organism Outcome Peer Review Phase Physiology Pilot Projects Population Positioning Attribute Prosthesis Publications Recovery Regenerative Medicine Research Research Infrastructure Research Personnel Resources Scientist South Carolina Strategic Planning Stroke Structure Technical Expertise Technology Testing Tissue Engineering Tissues Training Translational Research Translations United States National Institutes of Health Universities Xenograft procedure arm biofabrication bioimaging career clinical application clinically relevant cost design disability equipment acquisition faculty research fortification human disease improved innovation inter-institutional interdisciplinary collaboration interest member mortality multidisciplinary neural novel outreach program costs programs recruit stem cells success synergism targeted treatment tissue regeneration tissue repair translational goal voucher

项目摘要

This COBRE Phase III application is aimed at sustaining the research infrastructure built during the first ten years of NIGMS funding. Our COBRE “South Carolina Bioengineering Center for Regeneration and Formation of Tissues” has become a nationally recognized, collaborative center with unique strengths in bioengineering approaches to regenerative medicine. Three underlying themes define the Center's research: advance biomaterial design and application; in situ tissue repair with targeted therapies; and applying the principles of normal developmental biology to regenerative medicine or stem cell based tissue engineering. SC BioCRAFT accomplishments towards these three translational goals include the recruitment of 10 new faculty, mentoring and training of 23 COBRE target faculty, and the development of two research core facilities. Programmatic outcomes include 26 independent NIH research awards, 62 research awards from other agencies to target faculty, and >550 peer reviewed publications. South Carolina Centers of Economic Excellence: SmartState awarded three endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication in partnerships with Clemson and the University of South Carolina. SC BioCRAFT participated in the successful renewal of a statewide INBRE award with a focus on bioengineering/regenerative medicine. For this P30 application, the plan transitioning to independence of NIH/NIGMS support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness, to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A seven step, five-year strategic plan including implementing fee structures, pilot projects/voucher program, outreach activities and programmatic development is proposed to sustain the SC BioCRAFT/COBRE center and its scientific cores (Biomaterials Engineering and Testing and Translational Research Imaging). The founding director of Clemson's SC BioCRAFT COBRE will lead the Administrative Core and will be assisted by two outstanding scientists from Medical University of South Carolina who have themselves directed COBREs. Together, these three leaders will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Vice President for Research, ~2 million dollars, will help ensure programmatic growth development and long- term sustainability of the Center.

COBRE 第三阶段应用旨在维持前十年建立的研究基础设施我们的 COBRE“南卡罗来纳州再生和形成生物工程中心” Tissues”已成为全国公认的在生物工程领域具有独特优势的协作中心再生医学的方法定义了该中心的研究的三个基本主题：进步生物材料设计和应用；靶向治疗的原位组织修复和应用原理；正常发育生物学到再生医学或基于干细胞的组织工程。实现这三个转化目标的成就包括招聘 10 名新教师、提供指导培训 23 名 COBRE 目标教员，并开发两个研究核心设施。成果包括 26 项独立的 NIH 研究奖、62 项其他机构的研究奖教师和超过 550 份同行评审的出版物。南卡罗来纳州经济卓越中心：SmartState 与伙伴关系授予再生医学和先进组织生物制造领域的三名特聘教授与克莱姆森大学和南卡罗来纳大学一起成功更新了一个项目。省级INBRE奖，重点关注生物工程/再生医学。对于此 P30 申请，计划在未来五年内过渡到独立于 NIH/NIGMS 支持是增强和升级我们的核心技术，提高其竞争力，吸引更多的使用（和成本回收），并促进与我们中心的新研究合作，从而提交竞争性研究应用并扩大我们的共同范围，特别是其他 IDeA A 七中心。步骤，五年战略计划，包括实施费用结构、试点项目/优惠券计划、外展建议开展活动和计划开发以维持 SC BioCRAFT/COBRE 中心及其科学核心（生物材料工程和测试以及转化研究成像）。克莱姆森 SC BioCRAFT COBRE 主任将领导行政核心，并由两名来自南卡罗来纳医科大学的杰出科学家亲自指导 COBRE。这三位领导人将共同充当该中心的主要运营部门。将对中心的进展进行持续评估和评价。研究副总裁约 200 万美元，将帮助确保计划性增长发展和长期中心的长期可持续性。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

De Novo Self-Assembling Peptides Mediate the Conversion of Temozolomide and Delivery of a Model Drug into Glioblastoma Multiforme Cells.

从头自组装肽介导替莫唑胺的转化和模型药物向多形性胶质母细胞瘤细胞的递送。

DOI：
发表时间：
2022-09-02
期刊：
影响因子：
4.7
作者：
Pitz, Megan;Elpers, Margaret;Nukovic, Alexandra;Wilde, Sarah;Gregory, Arica Jordan;Alexander
通讯作者：
Alexander

Factors Affecting Secondary and Supramolecular Structures of Self-Assembling Peptide Nanocarriers.

影响自组装肽纳米载体二级和超分子结构的因素。

DOI：
10.1002/mabi.202100347
发表时间：
2021-11-20
期刊：
Macromolecular bioscience
影响因子：
4.6
作者：
Megan E. Pitz;Ale;ra Nukovic;ra;Margaret A. Elpers;Angela A Ale;er;er
通讯作者：
er

Assessing Anti-Adipogenic Effects of Mango Leaf Tea and Mangiferin within Cultured Adipocytes.

评估培养脂肪细胞内芒果叶茶和芒果苷的抗脂肪形成作用。

DOI：
发表时间：
2023-05-10
期刊：
影响因子：
0
作者：
Zarasvand, Sepideh Alasvand;Haley;Oladosu, Olanrewaju;Esobi, Ikechukwu;Powell, Rhonda Reigers;Bruce, Terri;Stamatikos, Alexis
通讯作者：
Stamatikos, Alexis

The development of a nucleus pulposus-derived cartilage analog scaffold for chondral repair and regeneration.

开发用于软骨修复和再生的髓核来源的软骨模拟支架。