The Development of a Biatrial Catheter for a Cardiopulmonary Support System in Pulmonary Arterial Hypertension

肺动脉高压心肺支持系统双心导管的研制

• 批准号: 10669968
• 负责人: RAYMOND Louis Benza
• 金额: $ 33.6万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10669968
• 关键词: Acute; Address; Animals; Aorta; Bed rest; Biomechanics; Blood; Blood flow; Brain; Cannulas; Cardiac; Cardiac Output; Cardiopulmonary; Catheters; Cessation of life; Chronic; Chronic Disease; Clinic; Clinical; Computer Simulation; Coupled; Custom; Data; Development; Devices; Disease; Docking; Engineering; Event; Extracorporeal Membrane Oxygenation; Functional disorder; Future; Gases; Generations; Genetic Complementation Test; Goals; Heart; Heart Atrium; Heart failure; Hospitals; Hour; Hypoxemia; In Vitro; Inequity; Internal jugular vein structure; Left; Left atrial structure; Left ventricular structure; Lower Extremity; Lung; Lung Transplantation; Marketing; Mechanics; Medical; Monitor; Morphology; Operative Surgical Procedures; Organ; Organ Donor; Oxygenators; Patients; Perfusion; Positioning Attribute; Process; Pulmonary Edema; Pulmonary Hypertension; Pulmonary artery structure; Pulmonary vessels; Pump; Recovery; Refractory; Resources; Right atrial structure; Right ventricular structure; Risk; Series; Sheep; Shunt Device; Side; Specific qualifier value; Support System; Surgeon; System; Testing; Time; Training; Transplantation; Treatment Efficacy; Validation; Venous; Vision; Waiting Lists; care costs; cohort; computer design; design; effective therapy; fabrication; hemodynamics; improved; in vivo evaluation; innovation; instrument; mortality; novel; novel therapeutics; operation; patient response; pharmacologic; portability; pressure; pressure sensor; prevent; prototype; pulmonary arterial hypertension; pulmonary arterial pressure; pulmonary vascular remodeling; right ventricular failure; sheep model; success; therapy design; time use; vascular injury

ABSTRACT Pulmonary arterial hypertension continues to be a devastating chronic disease. Despite a variety of new therapies, this disease process remains highly morbid and fatal. Most therapies are only temporizing and are minimally effective because of the insidious onset and late recognition of this disease process. Double lung transplantation is the only effective treatment; however, because of scarcity of organs and listing inequities, most patients are unlikely to receive a transplant while on the waiting list. Developing an effective long-term support system that can offload the right ventricle and protect the pulmonary vasculature would provide a bridge of support and potential for recovery or management on pharmacological support. The objective and long-term goal of this project is to design a catheter that will eventually be coupled with a pulmonary support system that can prolong the survival and enhance the ability to medically treat patients with pulmonary artery hypertension, as well as provide a chance for those on the lung transplant waiting list to receive an organ. We intend to accomplish this by developing an innovative dual lumen catheter that can be positioned and fixed for a prolonged period of time using a novel engineering mechanism and will properly unload the right ventricle and pulmonary vasculature via an inter-atrial configuration. This will further include an innovative monitoring system to monitor and control flows and protect a deconditioned left ventricle, preventing left sided heart failure.

抽象的 肺动脉高压仍然是一种毁灭性的慢性疾病。尽管有各种各样的新 尽管经过治疗，这种疾病过程仍然高度致病和致命。大多数疗法只是暂时的， 由于这种疾病发病隐匿且认识较晚，因此效果甚微。双肺 移植是唯一有效的治疗方法；然而，由于器官稀缺和名单不平等，大多数 患者在等待名单上不太可能接受移植。制定有效的长期支持 可以减轻右心室负担并保护肺血管系统的系统将提供一座桥梁 药物支持的支持和恢复或管理的潜力。目标和长远 该项目的目标是设计一种导管，最终将与肺支持系统相结合， 可以延长肺动脉高压患者的生存期并增强治疗能力， 并为肺移植等候名单上的人提供接受器官的机会。我们打算 通过开发一种创新的双腔导管来实现这一目标，该导管可以长时间定位和固定 使用新颖的工程机制一段时间后，将正确卸载右心室和肺 通过心房配置的脉管系统。这将进一步包括一个创新的监控系统来监控 控制血流并保护功能失调的左心室，防止左侧心力衰竭。