Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood
Suubi Adherence-R2:检查青年艾滋病毒感染者 (YLHIV) 过渡到成年早期的纵向艾滋病毒治疗依从性
基本信息
- 批准号:10661567
- 负责人:
- 金额:$ 91.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-30 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Acquired Immunodeficiency SyndromeAdherenceAdolescent and Young AdultAffectAfricaAfrica South of the SaharaAlcoholsAreaBehaviorBiologicalCaringChild DevelopmentChild HealthClinicCognitionCognitiveCognitive deficitsContinuity of Patient CareCountryDecision MakingDevelopmentDrug PrescriptionsEconomicsEnrollmentFailureFamilyFeeling hopelessFemaleHIVHIV antiretroviralHIV-associated neurocognitive disorderHIV/AIDSHealthHealth behaviorHomeIncentivesInterventionLifeLife Cycle StagesLong-Term EffectsMaintenanceMarriageMemoryMental DepressionMental HealthMentorshipOutcomeParticipantPharmaceutical PreparationsPhasePrevalenceProspective StudiesRandomizedRegimenReportingResearchResearch PriorityResourcesRiskRisk TakingRunningRuralSaharaSavingsSchoolsSelf EfficacySocial supportTrainingUgandaUnited States National Institutes of HealthViralViral Load resultYouthagedantiretroviral therapyarmcognitive developmentcognitive functioncognitive testingcomorbiditycomparison controlcomparison interventioncost effectivenessdrug misuseempowermentevidence baseexecutive functionexperiencefinancial literacyhigh riskimprovedinnovationmalemedical appointmentpeerprimary outcomeprogramsprospectiveprotective factorspsychologicsecondary analysissexual risk takingsocialsocial stigmastandard of caretheoriestherapy adherencetransmission processtreatment adherencetreatment armtwo-arm studyyoung adult
项目摘要
PROJECT ABSTRACT
This competing renewal to Suubi+Adherence study (R01HD074949) will examine the longitudinal HIV
antiretroviral therapy (ART) adherence and related outcomes, and the potential mechanisms of protective health
behaviors among youth living with HIV (YLHIV) who participated in an evidence-based family economic
empowerment (FEE) intervention in Uganda and are now transitioning into young adulthood. Sub-Saharan Africa
(SSA) has the highest HIV prevalence rate in the world. In Uganda, a poor SSA country hardest hit with HIV, the
prevalence of viral load suppression among adolescents and young adults (15 to 24 years old) is 44.9% for
females and 32.5% for males. For six years (2012-2018), the Suubi+Adherence study prospectively followed
702 YLHIV (aged 10 to 16 years at enrollment) randomized to two study arms across 39 clinics in Uganda: 1)
control arm consisting of bolstered standard of care (BSOC) and 2) intervention arm consisting of BSOC and a
FEE intervention. Study findings pointed to superior short-term viral suppression and positive child health and
mental health functioning among the intervention arm. This renewal (Suubi+Adherence-Round 2) proposes to
examine whether the results are maintained through young adulthood, an incredibly vulnerable transition period,
particularly in areas of adherence to HIV treatment, cognitive development, mental health, sexual risk taking
behaviors and alcohol/drug misuse. The renewal (2020-2025) will build on the Suubi+Adherence study to
conduct one of the largest and longest running studies of YLHIV in SSA during a developmental period marked
by profound biological and psychological maturation, and development transitional milestones. In this next
phase, we will add a qualitative component to examine participants' experiences with the FEE program as well
as long-term effects. Innovatively, we will also assess the impact of the FEE on cognitive functioning. The study
specific aims are: Aim 1. To examine the long-term impact of the Suubi+Adherence intervention on: HIV viral
suppression (primary outcome) and to explore the long-term impact of the intervention on key HIV treatment
adherence outcomes for YLHIV, including participants' ability to access and refill prescribed medication, adhere
to prescribed daily medication routines, and engage in HIV care; Aim 2. To elucidate the long-term effects of the
Suubi+Adherence intervention on potential mechanisms of change, including: a) economic stability, sexual risk-
taking behavior, adherence self-efficacy; b) cognitive functioning; c) mental health functioning; and d) young
adult transitions and social support; Aim 3. To qualitatively examine– prospectively and retrospectively: a) multi-
level factors affecting participants' maintenance of intervention benefits since Suubi+Adherence intervention
initiation (prospectively); and b) participants' experiences with the intervention (retrospectively), including multi-
level factors that may have influenced their engagement with the program and their decision-making in regard
to ART adherence; Aim 4. To examine the long-term cost-effectiveness of the Suubi+Adherence intervention.
The study is aligned with the National Institutes of Health Office of AIDS Research priorities.
项目摘要
这项 Suubi+Adherence 研究 (R01HD074949) 的竞争更新将检查纵向 HIV
抗逆转录病毒治疗(ART)依从性和相关结果,以及保护健康的潜在机制
参与循证家庭经济研究的艾滋病毒感染者 (YLHIV) 青少年的行为
乌干达的赋权(FEE)干预,目前正在过渡到撒哈拉以南非洲的青年期。
乌干达是世界上艾滋病毒感染率最高的SSA贫困国家,也是艾滋病毒感染最严重的国家。
青少年和年轻人(15 至 24 岁)病毒载量抑制率为 44.9%
Suubi+Adherence 研究对女性和男性 32.5% 进行了为期六年(2012-2018)的前瞻性跟踪。
702 名 YLHIV(入组时年龄为 10 至 16 岁)被随机分配到乌干达 39 个诊所的两个研究组:1)
控制臂由强化护理标准 (BSOC) 组成,2) 干预臂由 BSOC 和
FEE 干预研究结果表明,短期病毒抑制效果良好,对儿童健康和健康有积极影响。
干预组中的心理健康功能。本次更新(Suubi+依从性第二轮)建议:
检查结果是否能维持到成年早期,这是一个极其脆弱的过渡期,
特别是在坚持艾滋病毒治疗、认知发展、心理健康、性冒险等领域
更新(2020-2025)将以 Suubi+Adherence 研究为基础。
在 SSA 的发育阶段进行了规模最大、运行时间最长的 YLHIV 研究之一
通过深刻的生物和心理成熟,以及发展的过渡里程碑。
阶段,我们还将添加一个定性部分来检查参与者对 FEE 计划的体验
作为长期影响,我们还将评估 FEE 对认知功能的影响。
具体目标是: 目标 1. 检查 Suubi+Adherence 干预措施对以下方面的长期影响: HIV 病毒
抑制(主要结果)并探讨干预措施对关键艾滋病毒治疗的长期影响
YLHIV 的依从性结果,包括参与者获取和补充处方药物的能力、依从性
遵循日常用药习惯,并进行艾滋病毒护理; 目标 2. 阐明治疗的长期影响;
Suubi+对潜在变化机制的依从性干预,包括:a) 经济稳定、性风险-
采取行为、坚持自我效能;b) 认知功能;c) 心理健康功能;
成人过渡和社会支持;目标 3. 前瞻性和回顾性地定性检查:
自Suubi+依从性干预以来影响参与者维持干预效益的水平因素
b) 参与者的干预经验(回顾性),包括多方参与
可能影响他们参与该计划及其决策的水平因素
ART 依从性;目标 4. 检查 Suubi+依从性干预的长期成本效益。
该研究与美国国立卫生研究院艾滋病研究办公室的优先事项保持一致。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluating the literature of therapeutic landscapes with an emphasis on the search for the dimensions of health: A systematic review.
评估治疗景观文献,重点关注健康维度的搜索:系统评价。
- DOI:10.1016/j.socscimed.2021.113820
- 发表时间:2021-03-06
- 期刊:
- 影响因子:5.4
- 作者:Shima Taheri;Maryam Ghasemi sichani;A. Shabani
- 通讯作者:A. Shabani
Adaptation and Validation of the Shame Questionnaire Among Ugandan Youth Living with HIV.
乌干达艾滋病毒青年羞耻调查问卷的改编和验证。
- DOI:
- 发表时间:2019-06-15
- 期刊:
- 影响因子:2.8
- 作者:Michalopoulos, Lynn Murphy;Meinhart, Melissa;Barton, Sam Monroe;Kuhn, Jillian;Mukasa, Miriam N;Namuwonge, Flavia;Feiring, Candice;Ssewamala, Fred M
- 通讯作者:Ssewamala, Fred M
The relationship between life satisfaction, personal health, quality of life, and medication adherence among adolescents living with HIV in southwestern Uganda.
乌干达西南部艾滋病毒感染者的生活满意度、个人健康、生活质量和药物依从性之间的关系。
- DOI:
- 发表时间:2023-07
- 期刊:
- 影响因子:0
- 作者:Byansi, William;Nabunya, Proscovia;Muwanga, Joelynn;Mwebembezi, Abel;Damulira, Christopher;Mukasa, Barbara;Zmachinski, Lily;Nattabi, Jennifer;Brathwaite, Rachel;Namuwonge, Flavia;Bahar, Ozge Sensoy;Neilands, Torsten B;Mellins, Claude A;Ssewam
- 通讯作者:Ssewam
The impact of COVID-19 changes and disruptions on generalized anxiety disorder among young adults living with HIV (YLHIV) in Uganda.
COVID-19 的变化和干扰对乌干达年轻艾滋病毒感染者 (YLHIV) 广泛性焦虑症的影响。
- DOI:
- 发表时间:2024-02-06
- 期刊:
- 影响因子:3.2
- 作者:Girma, Abel Zemedkun;Brathwaite, Rachel;Karamagi, Yvonne;Nakabuye, Fatumah;Nakasujja, Noeline;Byansi, William;Nabunya, Proscovia;Sensoy Bahar, Ozge;Ssewamala, Fred M
- 通讯作者:Ssewamala, Fred M
Impact of Family-Based Economic Empowerment Intervention, Suubi+Adherence (2012-2018) on Multidimensional Poverty for Adolescents Living with HIV (ALWHIV) in Uganda.
基于家庭的经济赋权干预措施、Suubi 坚持(2012-2018 年)对乌干达艾滋病毒感染青少年 (ALWHIV) 多维贫困的影响。
- DOI:
- 发表时间:2022-11-02
- 期刊:
- 影响因子:0
- 作者:Dvalishvili, Darejan;Ssewamala, Fred M;Nabunya, Proscovia;Sensoy Bahar, Ozge;Kizito, Samuel;Namuwonge, Flavia;Namatovu, Phionah
- 通讯作者:Namatovu, Phionah
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Proscovia Nabunya其他文献
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{{ truncateString('Proscovia Nabunya', 18)}}的其他基金
Bridges-Round 2: Evaluating the Long-term Impact of a Family Economic Empowerment Intervention on HIV Risk Prevention and Care Continuum Outcomes among Orphaned Youth Transitioning to Young Adulthood
Bridges-Round 2:评估家庭经济赋权干预措施对过渡到青年时期的孤儿青少年的艾滋病毒风险预防和护理连续结果的长期影响
- 批准号:
10593954 - 财政年份:2022
- 资助金额:
$ 91.28万 - 项目类别:
Bridges-Round 2: Evaluating the Long-term Impact of a Family Economic Empowerment Intervention on HIV Risk Prevention and Care Continuum Outcomes among Orphaned Youth Transitioning to Young Adulthood
Bridges-Round 2:评估家庭经济赋权干预措施对过渡到青年时期的孤儿青少年的艾滋病毒风险预防和护理连续结果的长期影响
- 批准号:
10593954 - 财政年份:2022
- 资助金额:
$ 91.28万 - 项目类别:
Bridges-Round 2: Evaluating the Long-term Impact of a Family Economic Empowerment Intervention on HIV Risk Prevention and Care Continuum Outcomes among Orphaned Youth Transitioning to Young Adulthood
Bridges-Round 2:评估家庭经济赋权干预措施对过渡到青年时期的孤儿青少年的艾滋病毒风险预防和护理连续结果的长期影响
- 批准号:
10405349 - 财政年份:2022
- 资助金额:
$ 91.28万 - 项目类别:
Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents
Suubi4Stigma:解决青少年中与艾滋病毒相关的耻辱问题
- 批准号:
10204977 - 财政年份:2020
- 资助金额:
$ 91.28万 - 项目类别:
Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents
Suubi4Stigma:解决青少年中与艾滋病毒相关的耻辱问题
- 批准号:
10015712 - 财政年份:2020
- 资助金额:
$ 91.28万 - 项目类别:
Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood
Suubi Adherence-R2:检查青年艾滋病毒感染者 (YLHIV) 过渡到成年早期的纵向艾滋病毒治疗依从性
- 批准号:
10089139 - 财政年份:2012
- 资助金额:
$ 91.28万 - 项目类别:
Suubi+Adherence-R2: Examining the longitudinal HIV treatment adherence among youth living with HIV (YLHIV) transitioning into young adulthood
Suubi Adherence-R2:检查青年艾滋病毒感染者 (YLHIV) 过渡到成年早期的纵向艾滋病毒治疗依从性
- 批准号:
10451557 - 财政年份:2012
- 资助金额:
$ 91.28万 - 项目类别:
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