Tumor Immunology Program

肿瘤免疫学项目

• 批准号: 7674608
• 负责人: ROBERT DAVID SCHREIBER
• 金额: $ 5.34万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7674608
• 关键词: Address; Antigen Presentation Pathway; Antigens; Applications Grants; Area; Arts; Biochemistry; Biology; Cancer Center; Cancer Immunology Science; Clinical; Clinical Research; Communities; Computer Systems Development; Depth; Development; Developmental Biology; Ensure; Environment; Experimental Models; Experimental Neoplasms; Foundations; Funding; Future; Gene Targeting; Goals; Grant; Growth; Hematopoietic; Human; Immune response; Immune system; Immunodeficient Mouse; Immunologist; Immunology; Immunotherapeutic agent; Immunotherapy; Individual; Institution; Knockout Mice; Laboratories; Lymphocyte Biology; Malignant Neoplasms; Malignant neoplasm of pancreas; Mammary Neoplasms; Modeling; Mus; Myeloid Leukemia; Nature; Numbers; Pancreas; Pattern; Process; Program Research Project Grants; Prostatic; Prostatic Neoplasms; Protocols documentation; Range; Reproduction spores; Research; Research Project Grants; Resources; Role; T-Lymphocyte; Technology; Transgenic Organisms; Translations; Tumor Antigens; Tumor Cell Line; Universities; Washington; anticancer research; base; cancer immunology function; cytokine; fibrosarcoma; medical schools; member; novel; programs; success; trafficking; tumor; tumor immunology

During the past 17 years, Washington University School of Medicine has developed significant strength in the area of immunology. The Medical School community is known for its breadth and depth and its highly interactive nature. However, until recently, this community had very little focus in the specific area of tumor immunology. As a result of recent advances in the fields of basic and tumor-related immunology and the institutional commitment to support cancer research through the formation of the Alvin J. Siteman Cancer Center, this immunology community has enthusiastically drawn together with the intent of specifically addressing many of the key issues relevant to cancer immunology and immunotherapy. This effort resulted in the formation of the Tumor Immunology Research Program that currently comprises 30 members. The Program is focused into five thematic areas: (1) immune system development, (2) antigen processing and presentation, (3) lymphocyte biology, (4) cytokine biology and biochemistry, and (5) tumor immunotherapy. The long-range goal of this Program is to encourage development of cutting-edge tumor immunology research and facilitate its direct translation into novel immunotherapeutic protocols. Toward these ends, the following four immediate goals continue to be pursued: (1) to develop new experimental tumor models using transgenio and gene-targeted mice that more closely recapitulate clinical aspects of human cancer, (2) to encourage the channeling of some of the extraordinary strengths that already exist within the immunology community in the area of antigen processing and presentation into defining the nature and origins of tumor antigens, (3) to use the broad expertise base of the Program members to explore the roles of innate and adaptive immune response components in either promoting or suppressing anti-tumor immune responses, and (4) to increase the number of inter-departmental and/or collaborative tumor immunology research projects. The Program will achieve these goals by sponsoring a number of interactive scientific forums for its members and their research teams and by employing the resources of the Siteman Cancer Center and its cores to encourage the active and interactive participation of both its basic and clinically oriented members.

在过去的 17 年里，华盛顿大学医学院在以下领域发展了显着的实力： 免疫学领域。医学院社区以其广度、深度和高度而闻名。 互动性。然而，直到最近，这个社区还很少关注肿瘤的特定领域。 免疫学。由于基础免疫学和肿瘤相关免疫学领域的最新进展以及 通过成立 Alvin J. Siteman 癌症基金会来支持癌症研究的机构承诺 中心，这个免疫学界热情地聚集在一起，目的是专门 解决与癌症免疫学和免疫治疗相关的许多关键问题。这一努力的结果是 参与组建肿瘤免疫学研究项目，目前有 30 名成员。这 计划重点关注五个主题领域：(1) 免疫系统发育，(2) 抗原加工和 介绍，(3) 淋巴细胞生物学，(4) 细胞因子生物学和生物化学，(5) 肿瘤免疫治疗。 该计划的长期目标是鼓励尖端肿瘤免疫学的发展 研究并促进其直接转化为新型免疫治疗方案。为了实现这些目标， 继续追求以下四个近期目标：（1）开发新的实验性肿瘤模型 转基因和基因靶向小鼠更接近地再现人类癌症的临床方面，(2) 鼓励发挥免疫学领域已经存在的一些非凡优势 抗原加工和呈递领域的社区以确定肿瘤的性质和起源 抗原，(3) 利用计划成员广泛的专业知识基础来探索先天和 适应性免疫反应成分促进或抑制抗肿瘤免疫反应， (4) 增加跨部门和/或协作肿瘤免疫学研究的数量 项目。该计划将通过赞助一些互动科学论坛来实现这些目标 成员及其研究团队，并利用 Siteman 癌症中心及其资源 核心鼓励其基础和临床成员的积极和互动参与。