Molecular Pathogenesis of Digestive Diseases

消化系统疾病的分子发病机制

• 批准号: 7414773
• 负责人: Harry Bernard Greenberg
• 金额: $ 111.91万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414773
• 关键词: Molecular; Pathogenesis; Digestive; Diseases; Molecular; Pathogenesis; Digestive; Diseases

DESCRIPTION, OVERALL (provided by applicant): The Digestive Disease Center at Stanford University has two areas of focus. The first deals with studying host-pathogen interactions in the Gl tract and liver, with an emphasis on host and microbial determinants of pathogenesis and immunity. Infections under study include hepatitis A-D, polio virus, H. pylori, and diarrheal agents such as rotavirus, salmonella, E. coli, cholera, Entamoeba histolytica and the Whipple's bacillus. The second focus addresses the cell and molecular biology of digestive epithelia and gastrointestinal immunology with emphasis on normal and abnormal cell growth including malignant transformation, differentiation, development, cell polarity, the cytoskeleton and the role of immune mechanisms in autoimmune Gl diseases, transplantation and Gl infections, both acute and chronic. This focus targets several important digestive diseases including esophageal, pancreatic and colorectal cancer; acute and chronic liver diseases including viral and autoimmune liver disease; pancreatitis, Barrett's esophagus, inflammatory bowel disease and transplant rejection. The center consists of 32 established investigators who blend several clinical and basic science departments. The center consists of five cores. The Administrative Core offers the Pilot/Feasibility Program which provides one year of funding ($25,000/year) to junior investigators or those with a novel or collaborative project; the Named Investigator Program which provides 1 or 2 year 15-25% effort/year support to a promising junior faculty; the Enrichment Program consisting of regular seminars, visiting lectures, and an annual symposium; and a Clinical Component consisting of biostatistical and data management support for clinical studies. The Fluorescence Activated Cell Sorting/lmmunoprobe Core offers an array of services that allow studying single cells and the generation of monoclonal antibodies. The Cell Imaging Core offers state-of-the-art imaging tools including confocal and electron microscopy. The Proteomics and Genomics Core offers the ability to identify disease-associated regulatory changes in genes or their proteins via microarray and mass spectrometry analysis. Finally, the Animal Imaging and Physiology Core offers unparalleled access to state-of-the-art imaging capabilities in a variety of formats and assistance in small animal surgery, organ perfusion and cell isolation. Thus, this center brings together an accomplished group of investigators, creates a highly interactive environment, and makes available state of the art technologies to address important digestive diseases.

描述，总体（由申请人提供）： 斯坦福大学的消化疾病中心有两个重点。第一个涉及在GL道和肝脏中研究宿主 - 病原体相互作用，重点是发病机理和免疫力的宿主和微生物决定因素。研究中的感染包括肝炎A-D，脊髓灰质炎病毒，幽门螺杆菌和腹泻剂，例如轮状病毒，沙门氏菌，大肠杆菌，霍乱，霍乱，霍乱，溶血性溶酶体和惠普的芽孢杆菌。第二个焦点是消化性上皮症和胃肠道免疫学的细胞和分子生物学，重点是正常和异常细胞生长，包括恶性转化，分化，发育，细胞极性，细胞骨架以及免疫机制在自身免疫性的疾病，移植和囊肿感染和GL IFCECTIONT和GLECTIONT和CHRECTIONT和CHROCUTE，CHRICET，ACERICT和CHRONECTION中的作用。该重点针对几种重要的消化疾病，包括食管，胰腺癌和结直肠癌。急性和慢性肝病，包括病毒和自身免疫性肝病；胰腺炎，巴雷特的食道，炎症性肠病和移植排斥。该中心由32名既定研究人员组成，他们融合了多个临床和基础科学部门。 该中心由五个核心组成。行政核心提供了试点/可行性计划，该计划为初级调查人员或具有新颖或协作项目的人提供一年的资金（每年25,000美元）；命名的调查员计划为有前途的初级教师提供1或2年的15-25％的努力/年支持；由常规研讨会，访问讲座和年度研讨会组成的丰富计划；以及由生物统计和数据管理支持临床研究组成的临床成分。荧光激活的细胞分选/LMMUNOPROBE CORE提供了一系列服务，可研究单克隆抗体的产生。细胞成像核心提供最先进的成像工具，包括共聚焦和电子显微镜。蛋白质组学和基因组学核心提供了通过微阵列和质谱分析鉴定基因或其蛋白质中疾病相关的调节性变化的能力。最后，动物成像和生理核心提供了各种格式的最先进成像功能的无与伦比的访问，并在小型动物外科手术，器官灌注和细胞隔离方面提供了帮助。因此，该中心汇集了一群成熟的研究人员，创造了一个高度交互的环境，并提供了最先进的技术来解决重要的消化系统疾病。