Health and Metabolism Research Core

健康与新陈代谢研究核心

基本信息

批准号：
10659064
负责人：
Cory Williams
金额：
$ 23.76万
依托单位：
UNIVERSITY OF ALASKA FAIRBANKS
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-16 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10659064
关键词：
3-Dimensional Adipose tissue Agreement Alaska Alaskan Animal Model Animals Applied Research Arctic Regions Basic Science Biological Blood Glucose Blood Pressure Body Composition Body Temperature Bone Density Bone Mineral Contents Businesses Centers of Research Excellence Chemicals Clinical Clinical Research Clinical Sciences Collaborations Collection Communities Computer software Consultations Custom Data Data Analyses Data Science Dedications Development Diagnostic Imaging Discipline Doctor of Philosophy Dual-Energy X-Ray Absorptiometry Electrocardiogram Elements Ensure Equipment Essential Amino Acids Fatty acid glycerol esters Fees Foundations Goals Health Hibernation Homeostasis Hospitals Human Human Resources Human Subject Research Idaho Image Implant In Vitro Infrastructure International Intervention Isometric Exercise Kinetics Laboratories Lipids Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mammals Martes zibellina Mercury Metabolic Metabolic Diseases Metabolism Methodology Monitor Montana NMR Spectroscopy Oxygen Consumption Participant Peripheral Phase Physiological Play Population Heterogeneity Protons Research Research Personnel Research Project Grants Research Support Resources Rodent Roentgen Rays Scientist Services Shapes Site Spirometry System Techniques Telemetry Testing Thinness Time Tissues Translating Translational Research Universities Urea Nitrogen Washington Wyoming base chemical reaction clinical care computerized data processing data acquisition density design effective intervention experimental study flexibility health goals human model human subject imaging facilities in vivo in vivo imaging instrument instrumentation interdisciplinary collaboration intrahepatic lean body mass metabolomics microbial molecular imaging operation patient oriented research programs research facility research study respiratory small molecule spectroscopic imaging tool

项目摘要

Project Summary – Health and Metabolism Research (HaMR) Core In vivo imaging and animal instrumentation are key elements of the proposed COBRE Center for Transformative Research in Metabolism. The Health and Metabolism Research (HaMR) Core combines an existing Molecular Imaging Facility with existing equipment and expertise in animal instrumentation. The goal of the Core is to co-locate basic research in hibernation with human subject's research to promote interdisciplinary collaboration and transformative discoveries and to adapt to the needs of the proposed COBRE Center. We will accomplish this goal by accomplishing the following Specific Aims (SA). SA1. Support the Molecular Imaging Facility (MIF) to provide technical assistance, expert consultation, and sophisticated, state-of-the-art instrumentation for in-vivo and in-vitro basic and translational research. SA2. To support project PIs and other COBRE investigators in the collection & processing of metabolic and physiological data using animal instrumentation. SA3. To implement and continually refine our business plan for long-term sustainable operation of the Core. The HaMR Core houses the only research dedicated magnetic resonance facility in the UA system and in the state of Alaska, enhancing capacity for basic research using unique Arctic animal models and for translational and clinical research in Alaskan human subjects. The HaMR Core is an essential component of the Research Projects supported by the Phase 1 COBRE, providing technical assistance, expert consultation, and instrumentation for basic and clinical research. The Core includes a Molecular Imaging Facility, established in 2014, that houses a Toshiba 1.5 Tesla MRI, two NMRs (300 and 600MHz), and a Dual-energy X-ray Absorptiometry (DXA) instrument. This facility is an important regional resource, identified as a clinical research center site within the Northwest Participant and Clinical Interactions Network (NW PCI). HaMR Core services include technical support and expertise in methodologies for monitoring metabolism, via open-flow respirometry and biotelemtry, in hibernating species and laboratory rodents.

项目摘要 – 健康与代谢研究 (HaMR) 核心体内成像和动物仪器是拟议的 COBRE 中心的关键要素代谢的变革性研究。健康与代谢研究 (HaMR) 核心结合了现有的分子成像设施以及动物仪器方面的现有设备和专业知识。核心内容是将冬眠基础研究与人类受试者研究放在一起，以促进跨学科合作和变革性发现，并适应拟议的需求 COBRE 中心将通过实现以下具体目标 (SA) 来实现这一目标。分子成像设施（MIF）提供技术援助、专家咨询和用于体内和体外基础和转化研究的先进、先进的仪器 SA2。支持项目 PI 和其他 COBRE 研究人员收集和处理代谢数据使用动物仪器进行生理数据实施和不断完善我们的业务。 HaMR 核心拥有唯一的专门研究机构。 UA系统和阿拉斯加州的磁共振设施，增强基础研究能力使用独特的北极动物模型，对阿拉斯加人类受试者进行转化和临床研究。 HaMR Core 是 COBRE 第一阶段支持的研究项目的重要组成部分，提供基础和临床研究的技术援助、专家咨询和仪器。包括 2014 年建立的分子成像设施，配备东芝 1.5 Tesla MRI、两台 NMR （300 和 600MHz），以及双能 X 射线吸收测定 (DXA) 仪器。区域资源，被确定为西北参与者和临床中心内的临床研究中心站点交互网络 (NW PCI) 核心服务包括技术支持和方法学专业知识。通过开放式呼吸测量法和生物遥测技术，在冬眠物种和实验室中监测新陈代谢啮齿动物。