Training Program in Translational Neuromodulation

转化神经调节培训计划

• 批准号: 10659148
• 负责人: Matthew Douglas Johnson
• 金额: $ 35.82万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10659148
• 关键词: Training Programs; neuroregulation

PROJECT SUMMARY Neuromodulation is a rapidly growing field of study that encompasses a wide spectrum of neurotechnology that can manipulate neural circuits for treating nervous system disorders. To accelerate clinical translation of neuromodulation therapies, there is a strong need to train the next generation of scientists, engineers, and clinicians who have the knowledge base and circuit-interrogating tools to investigate nervous system disorders, the principled biophysical understanding of how neuromodulation affects neural tissue, the communication and scientific skills to work in multi-disciplinary teams, and the ability to navigate the translational pathways necessary to bring new discoveries and technologies to clinical practice. The mission of this T32 program is to train a diverse group of post-doctoral fellows, provide them with world-class opportunities to develop and translate neuromodulation technologies, and launch their careers as the next generation of leaders in the field of translational neuromodulation research. The training program will pair post-doctoral fellows with faculty co- mentors from (1) fundamental neuroscience or neuroengineering fields and (2) clinical disciplines. Fellows will conduct translational research with program faculty who are pioneers in the clinical translation of (a) deep brain stimulation therapies for neurological and neuropsychiatric disorders, (b) spinal cord stimulation for post-injury restoration of volitional movement and autonomic function, (c) peripheral nerve stimulation for treatment of cardiometabolic and inflammatory disorders, and (d) techniques for manipulating the spread of brain cancer. Fellows will participate in a clinical immersion and have the opportunity to integrate and lead aspects of research projects that are already in human clinical trials or near the threshold for first-in-human studies. The training program will also engage a cohort of resident- or fellowship-level physicians (“clinical associates”) who can devote one year of protected and already funded research time. All trainees will further develop their skills in rigorous statistical data analysis, experimental design methodologies, research quality assurance, and responsible conduct of research through hands-on workshops. We will also train the cohort of fellows and clinical associates through a translation and commercialization bootcamp with follow-up workshop sessions. This program will tap into outstanding translational neuromodulation research programs and facilities at the University of Minnesota and integrate our fellows into the unique medical device ecosystem of Minnesota, which is home to many global medtech companies that are developing neuromodulation technologies.

项目概要 神经调节是一个快速发展的研究领域，涵盖广泛的神经技术 可以操纵神经回路来治疗神经系统疾病，以加速临床转化。 神经调节疗法，迫切需要培训下一代科学家、工程师和 拥有知识库和电路询问工具来研究神经系统疾病的前沿， 对神经调节如何影响神经组织、沟通和交流的原则性生物物理学理解 在多学科团队中工作的科学技能以及驾驭转化途径的能力 将新发现和技术引入临床实践是必要的，该 T32 计划的使命是 培养多元化的博士后团队，为他们提供世界一流的发展和发展机会 转化神经调节技术，并作为该领域的下一代领导者开启他们的职业生涯 该培训计划将博士后研究员与教职员工配对。 来自 (1) 基础神经科学或神经工程领域的导师和 (2) 临床学科的研究员。 与项目教员一起进行转化研究，他们是（a）深部大脑临床转化的先驱 针对神经和神经精神疾病的刺激疗法，(b) 针对损伤后的脊髓刺激 恢复意志运动和自主功能，(c) 周围神经刺激治疗 心脏代谢和炎症性疾病，以及（d）控制脑癌扩散的技术。 研究员将参与临床沉浸式学习，并有机会整合和领导各个方面 已经进入人体临床试验或接近首次人体研究门槛的研究项目。 培训计划还将聘请一批住院医师或研究员级别的医生（“临床助理”），他们 可以投入一年受保护且已获得资助的研究时间 所有学员将进一步发展他们的技能。 严格的统计数据分析、实验设计方法、研究质量保证，以及 我们还将通过实践研讨会来负责任地进行研究。 临床同事通过翻译和商业化训练营以及后续研讨会课程。 该项目将利用杰出的转化神经调节研究项目和设施 明尼苏达大学并将我们的研究员融入明尼苏达州独特的医疗设备生态系统， 这里是许多正在开发神经调节技术的全球医疗科技公司的所在地。