The Role of Mycoplasma Genitalium in Infertility

生殖支原体在不孕症中的作用

• 批准号: 7979774
• 负责人: DAVID H. MARTIN
• 金额: $ 12.47万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7979774
• 关键词: Address; Antigens; Bacterial Adhesins; Biological Assay; Chronic; Cicatrix; Code; Complication; Data; Ectopic Pregnancy; Endometritis; Enrollment; Environment; Fallopian Tube Diseases; Genes; Genetic; Genital system; Genitourinary system; Healthcare; High Risk Woman; Human; Immune response; Immune system; Individual; Infection; Infertility; Lipoproteins; Local Microbicides; Louisiana; Mammalian Oviducts; Medical center; Membrane Proteins; Methods; Mutation; Mycoplasma genitalium; Organism; Pan Genus; Pelvic Inflammatory Disease; Population; Prevention; Proteins; Randomized; Recombinants; Reporting; Research; Risk; Role; Screening procedure; Serological; Sexual Partners; Specimen; Surface; Time; Universities; Urethritis; Woman; cohort; effective therapy; high risk; men; pathogen; prevent; research study; sample collection; treatment trial

Mycoplasma genitalium has been found to be associated with nongonococcal urethritis in men and there is some evidence to suggest that it may be a significant pathogen in women as well. It has been associated with mucopurulent cervictis in two studies. The major complication of bacterial STIs in women is infection of the upper genital tract resulting in pelvic inflammatory disease (PID) and fallopian tube scarring, which in turn cause ectopic pregnancy and/or infertility. There are a few reports suggesting that M. genitalium also causes these complications but these studies have not yielded consistent results. One serologic study suggests that the organism is associated with "tubal factor" infertility. If this should in fact turn out to be true then M. genitalium will be added to the list of significant bacterial STIs that should be prevented through effective treatment of symptomatic individuals and their sexual partners and by screening and treatment of asymptomatic high risk women and men. We will address this important issue in the first two Aims of this study as follows: 1. We will study a group of infertile women with and without fallopian tube disease drawn from a high STI risk population in New Orleans using our well established MG PCR assay and a specific serologic assay using recombinant M. genitalium lipoprotein antigens that we will develop. 2. We will study women at high risk of becoming infertile enrolled in a randomized infertility prevention treatment trial. Finally, in the third Aim we will study genetic mechanisms that this organism may use to escape the host immune system using specimens obtained from chronically infected chimpanzees and humans

已发现分枝菌生殖器与男性的非核菌尿道炎有关，并且有 一些证据表明，这也可能是女性的重要病原体。它已经关联了 在两项研究中与粘妥核。妇女细菌性传播性传播感染的主要并发症是感染 上生殖道导致骨盆炎症性疾病（PID）和输卵管疤痕 导致异位妊娠和/或不育。有一些报道表明，生殖器分枝杆菌也会引起 这些并发症但这些研究并未产生一致的结果。一项血清学研究表明 该生物与“管子因子”不育症有关。如果这实际上应该是真实的。 生殖器将被添加到重要细菌性传播疾病的列表中 治疗有症状的人及其性伴侣，并通过筛查和治疗 无症状的高风险男女。我们将在前两个目标中解决这个重要问题 研究如下：1。我们将研究一群有或没有输卵管疾病的不育妇女 使用我们已建立的MG PCR分析和特定的新奥尔良STI风险人群 我们将开发的重组脂蛋白抗原生殖器分枝杆菌的血清学测定。 2。我们将学习 有不育的高风险妇女参加了一项随机不孕治疗试验。最后， 在第三个目标中，我们将研究该生物可能用来逃避宿主免疫的遗传机制 系统使用从长期感染的黑猩猩和人类获得的标本