Integrated Virginia Research Training Centers in KUH (IGNITE KUH)

KUH 弗吉尼亚综合研究培训中心 (IGNITE KUH)

• 批准号: 10657702
• 负责人: John Christopher Chappell
• 金额: $ 28.9万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10657702
• 关键词: Address; American; Appalachian Region; Area; Award; Biomedical Engineering; Biomedical Research; COVID-19 pandemic; Clinical Research; Clinical Sciences; Clinical and Translational Science Awards; Collaborations; Data Science; Development; Dialysis procedure; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Education; Educational process of instructing; End stage renal failure; Enrollment; Environment; Event; Exposure to; Fostering; Funding; Future; Goals; Growth and Development function; Health; Healthcare; Hematology; Historically Black Colleges and Universities; Home; Human Resources; Immunity; Inflammation; Institution; Investigation; Kidney; Kidney Diseases; Kidney Transplantation; Medicine; Mentors; Modernization; Pathway interactions; Patient Care; Phase; Population Heterogeneity; Postdoctoral Fellow; Predictive Analytics; Program Development; Program Evaluation; Research; Research Institute; Research Methodology; Research Personnel; Research Training; Resource Development; Resources; Rural; Science; Scientific Advances and Accomplishments; Services; Students; Surveys; Systems Biology; Technology; Telecommunications; Teleconferences; Telemedicine; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Urology; Virginia; Work; burden of illness; career; catalyst; clinical center; college; design; drug discovery; efficacy evaluation; faculty mentor; functional genomics; fundamental research; innovation; inter-institutional; nanotherapeutic; next generation; outreach; parity; peer; post-doctoral training; pre-doctoral; programs; prospective; recruit; telehealth; tool; training opportunity; translational health science; undergraduate student; underrepresented minority student; underserved students

Center for Survey Research (CSR). Originally, we sought assistance from the CSR to assess the efficacy of the training program to conduct a mixed-mode, multi-phase program evaluation across three key stakeholder groups: (a) predoctoral and postdoctoral trainees; (b) faculty mentor; and (c) prospective trainees. Support was requested for Kara Fitzgibbon, PhD, Director, Center for Survey Research, Weldon Cooper Center for Public Service, UVA, and her team. For Year 1 we will assume more of this responsibility internally. Funds for this activity will be requested for subsequent out years. Most of the reductions were staff and key personnel support. We will continue to achieve the aims of the proposal with assistance from our respective institutions. We do not anticipate other changes.

调查研究中心（CSR）。最初，我们寻求 CSR 的帮助来评估培训计划的有效性，以便对三个关键利益相关者群体进行混合模式、多阶段的计划评估：（a）博士前和博士后学员； (b) 导师； (c) 未来的受训者。请求为 UVA 韦尔登库珀公共服务中心调查研究中心主任 Kara Fitzgibbon 博士及其团队提供支持。在第一年，我们将在内部承担更多的责任。今后几年将要求为这项活动提供资金。 大部分削减是员工和关键人员支持。我们将继续 在我们各自机构的协助下实现该提案的目标。 我们预计不会发生其他变化。

项目成果

Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production.

Fluvastatin 增强 IL-33 介导的肥大细胞 IL-6 和 TNF 的产生。

• 发表时间: 2022-01
• 影响因子: 4.3
• 作者: Taruselli, Marcela T;Kolawole, Elizabeth Motunrayo;Qayum, Amina Abdul;Haque, Tamara T;Caslin, Heather L;Abebayehu, Daniel;Kee, Sydney A;Dailey, Jordan M;Jackson, Kaitlyn G;Burchett, Jason R;Spence, Andrew J;Pondicherry, Neha;Barnstein, Brian O
• 通讯作者: Barnstein, Brian O

Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients.

年轻和老年 COVID-19 患者的不同体液免疫反应。

• 发表时间: 2021-06-29
• 影响因子: 6.4
• 作者: Sasson, Jennifer M;Campo, Joseph J;Carpenter, Rebecca M;Young, Mary K;Randall, Arlo Z;Trappl;Oberai, Amit;Hung, Christopher;Edgar, Joshua;Teng, Andy A;Pablo, Jozelyn V;Liang, Xiaowu;Yee, Angela;Petri Jr, William A;Camerini, D
• 通讯作者: Camerini, D

Altered DNA methylation underlies monocyte dysregulation and innate exhaustion memory in sepsis.

DNA 甲基化的改变是脓毒症中单核细胞失调和先天衰竭记忆的基础。

• 发表时间: 2023-08-31
• 作者: Caldwell, Blake A;Wu, Yajun;Wang, Jing;Li, Liwu
• 通讯作者: Li, Liwu

Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis.

DNA 甲基化的改变是脓毒症中单核细胞失调和免疫衰竭记忆的基础。

• 发表时间: 2024-03-26
• 影响因子: 8.8
• 作者: Caldwell, Blake A;Wu, Yajun;Wang, Jing;Li, Liwu
• 通讯作者: Li, Liwu

IgG Antibodies against SARS-CoV-2 Correlate with Days from Symptom Onset, Viral Load and IL-10.

针对 SARS-CoV-2 的 IgG 抗体与症状出现的天数、病毒载量和 IL-10 相关。

• 发表时间: 2020-12-07
• 作者: Young, Mary K;Kornmeier, Christine;Carpenter, Rebecca M;Natale, Nick R;Sasson, Jennifer M;Solga, Michael D;Mathers, Amy J;Poulter, Melinda D;Qiang, Xiao;Petri Jr, William A
• 通讯作者: Petri Jr, William A