Dynamic Multi-Channel TMS with Reconfigurable Coil

具有可重构线圈的动态多通道 TMS

• 批准号: 7797413
• 负责人: Ji Chen
• 金额: $ 18.63万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797413
• 关键词: Area; Behavior; Behavior Disorders; Brain; Brain region; Businesses; Cephalic; Collaborations; Complex; Computer Simulation; Computers; Development; Devices; Distant; Failure; Feedback; Goals; Institution; Lead; Location; Magnetism; Mood Disorders; Nature; Neurosciences; Pathway interactions; Patients; Pattern; Perception; Research; Research Personnel; Research Project Grants; Resolution; Role; Safety; Sensory; Site; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Staging; Stimulus; Surface; System; Technology; Testing; Time; base; commercialization; cost; design; feeding; flexibility; human subject; magnetic field; novel; phantom model; prototype; public health relevance; relating to nervous system; research study

DESCRIPTION (provided by applicant): Most behaviors arise from complex interactions between distant anatomical areas. These areas receive neural information asynchronously in time. To investigate behavior while still maintaining the timing of information that occurs during real sensory stimulation, an external stimulation system with reasonable spatio-temporal resolution is needed. Current trans-cranial magnetic stimulation (TMS) technology is limited to single brain regions. The goal of the proposed research is to develop a novel TMS system based on multi-channel reconfigurable coils. With this hardware, researchers will be able to reproducibly stimulate multiple brain sites in any temporal order-in the same experiment and on a single experimental trial. This design has applications in basic neuroscience. We also anticipate that the dynamic TMS could be useful to treat mood disorders and other psychiatric problems. The proposed system will employ a wire-mesh coil, which will be constructed using several x-directional wires and several y-directional wires. By varying the current direction and/or strength on each wire, we can configure this mesh-wire coil into a standard loop coil and figure-8 coil of varying size. This provides maximum flexibility to the experimenter in that the location and extent of stimulation on the brain surface can be modified depending on experimental requirement. Moreover, one can dynamically and automatically modify the site(s) of stimulation several times within the span of seconds. By pre-storing various sequences of excitation patterns inside a control unit, one can explore the effect of dynamic TMS on behavior and as therapy. The specific objectives are: 1. To develop a prototype dynamic TMS device containing reconfigurable coils. 2. To test the ability of the reconfigurable coils to deliver focused magnetic fields of sufficient strength to selectively excite or inhibit selected brain regions in a phantom model. 3. To assess the safety and failure modes of the system. PUBLIC HEALTH RELEVANCE: We will develop a novel Transcranial Magnetic Stimulator (TMS) coil that can dynamically and automatically modify the site(s) of stimulation several times within the span of seconds.

描述（由申请人提供）：大多数行为来自遥远的解剖区域之间的复杂相互作用。 这些领域随着时间的及时接收神经信息。 为了调查行为，同时仍保持实际感觉刺激期间发生的信息的时机，需要具有合理时空分辨率的外部刺激系统。 当前的经颅磁刺激（TMS）技术仅限于单脑区域。 拟议的研究的目的是开发基于多通道可重构线圈的新型TMS系统。 使用此硬件，研究人员将能够在同一实验和单个实验试验中可重复刺激多个大脑位点。 该设计在基本神经科学中有应用。 我们还预计，动态TMS对于治疗情绪障碍和其他精神病问题可能会很有用。 提出的系统将采用电线网线圈，该线圈将使用多个X方向线和几条Y方向线构造。 通过改变每条电线上的电流方向和/或强度，我们可以将此网状线圈配置为标准的环线圈和尺寸变化的图8线圈。 这为实验者提供了最大的灵活性，因为可以根据实验要求来修改脑表面刺激的位置和程度。 此外，人们可以在秒的时间内几次动态，自动修改刺激的位点。 通过预先存储控制单元内的各种激发模式，可以探索动态TMS对行为和作为治疗的影响。 特定目标是：1。开发包含可重构线圈的原型动态TMS设备。 2。测试可重构线圈提供足够强度的聚焦磁场的能力，以选择性地激发或抑制幻影模型中选定的大脑区域。 3。评估系统的安全性和故障模式。 公共卫生相关性：我们将开发一种新型的经颅磁刺激器（TMS）线圈，该线圈可以在几秒钟内几次动态并自动修改刺激位点。