Genetic Elements Controlling Blood Pressure

控制血压的遗传因素

基本信息

批准号：
7798169
负责人：
BINA JOE
金额：
$ 56.44万
依托单位：
UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-06-01 至 2013-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7798169
关键词：
Address Alleles Blood Pressure CD36 gene Candidate Disease Gene Cardiovascular system Chromosomes Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 9 Congenic Strain Custom Data Development Disintegrins Dissection Elements Essential Hypertension Etiology Figs - dietary Funding Gene Expression Gene Expression Profiling Genes Genetic Genetic Determinism Genetic Models Genetic Predisposition to Disease Genetic Transcription Genetic Variation Genome Genomics Global Change Goals Human Hypertension Hypotension Inbred Dahl Rats Inbred SHR Rats Indium Knowledge Laboratories Lead Link Literature Maps Metalloproteases Methodology Methods Mixed Function Oxygenases Modeling Nucleotides Play Predisposition Progress Reports Public Health Quantitative Trait Loci Rat Strains Rattus Reporting Research Resistance Resolution Role Testing Transgenic Organisms Variant Work base blood pressure regulation congenic design expectation genetic element improved normotensive novel overexpression rat genome research study salt sensitive trait transcription factor

项目摘要

DESCRIPTION (provided by applicant): Among all the hypertensive subjects combined, >90% develop hypertension for no known reasons, also called as Essential hypertension. Although it is well known that genetics play a major role in conferring susceptibility to develop essential hypertension, the identities of the genes/genetic factors that are causally responsible for essential hypertension remaining largely unknown is the single biggest rate-limiting factor in advancing our understanding of the etiology of essential hypertension. Using a rat genetic model for hypertension, we have located regions on the rat genome as responsible for controlling BP. This region, if mapped to the resolution of single genetic elements, can then be utilized for querying similar genetic elements as causative of hypertension in humans. The aims of our proposal are to therefore identify the genetic determinants of BP on three regions that we have already fine-mapped. The significance of our proposal is that it is potentially on the verge of unraveling novel genetic factors in the etiology of Essential Hypertension. PUBLIC HEALTH REVELANCE: Genetics is well recognized to be an important factor that contributes to the development of hypertension, which leads to cardiovascular related illnesses. The research work described in this proposal pertains to improve our current, significantly limited understanding of the identities of genes that control blood pressure. Knowledge gained through successful completion of the work described is expected to identify genetic factors that have not been previously suspected to cause hypertension.

描述（由申请人提供）：在所有高血压受试者中，> 90％的人出于未知原因出现高血压，也称为必不可少的高血压。尽管众所周知，遗传学在赋予发展基本高血压的敏感性方面起着重要作用，但由于因果关系负责基本高血压的基因/遗传因素的身份仍然很大程度上是未知的，这是促进我们对我们对基本高血压的病因的理解来促进我们的一项最大的限制因素。使用大鼠遗传模型进行高血压，我们将大鼠基因组上的区域定位为负责控制BP的区域。然后，如果将该区域映射到单个遗传元件的分辨率，则可以用于查询类似的遗传因素，以作为人类高血压的原因。因此，我们的建议的目的是确定BP在我们已经精细映射的三个区域上的遗传决定因素。我们提议的意义在于，它可能处于基本高血压病因中新的遗传因素的边缘。公共卫生的启示：遗传学被广泛认为是导致高血压发展的重要因素，这导致了心血管相关的疾病。该提案中描述的研究工作涉及改善我们当前对控制血压的基因身份的理解。通过成功完成所描述的工作获得的知识有望确定以前尚未怀疑引起高血压的遗传因素。