Training Research Leaders in Type 1 Diabetes

培训 1 型糖尿病研究领导者

基本信息

批准号：
10655524
负责人：
David Matthew Maahs
金额：
$ 42.54万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655524
关键词：
Adult Affinity Area Behavioral Sciences Biomedical Engineering Caliber Cellular biology Childhood Clinical Clinical Trials Diabetes Mellitus Diabetes prevention Direct Costs Educational Curriculum Endocrinologist Endocrinology Environment Faculty Foundations Funding Genetic Genomics Grant Immunologic Monitoring Immunology Instruction Insulin-Dependent Diabetes Mellitus Investigation Islet Cell K-12 Faculty Medicine Mentored Clinical Scientist Development Program Mentors Metabolism Pancreas Physicians Positioning Attribute Research Research Personnel Research Training Science Scientist Services Signal Transduction Structure Technology Training Training Programs Training and Education Transplantation Universities base bench to bedside career career development catalyst experience islet multidisciplinary novel therapeutics patient oriented programs research and development success

项目摘要

PROJECT SUMMARY The prime objective of the Stanford K12 “Training Research Leaders in Type 1 Diabetes” is the education and training of researchers for academic careers in Pediatric and Adult Endocrinology with a specific focus on type 1 diabetes (T1D). Our K12 program has three key training components: 1) a mentored research experience, 2) didactic instruction, and 3) mentoring and career development training. One of the distinguishing features of our program are the accomplishments of the program’s faculty and the strength of the research environment of Stanford University. We base the scientific foundation of this K12 training grant upon the structure of our recently P30 funded Stanford Diabetes Research Center (SDRC) and the successful training program of the long-standing Stanford Diabetes, Endocrinology, and Metabolism T32. The SDRC provides services via four strategic research cores: 1) Clinical and Translational Core; 2) Genomics and Analysis Core; 3) Islet Research Core; 4) Immune Monitoring Core. In addition to the research cores, the SDRC has grouped the 98 SDRC investigators into four broad research ‘affinity’ areas: 1) Pancreas and Islet Research; 2) Metabolism and Signaling in Diabetes; 3) Diabetes Immunology and Transplantation; 4) Diabetes, Bioengineering, and Behavioral Sciences. This K12 will leverage existing T32, P30, and campus wide curricula of study and research experiences to provide our T1D focused K12 scholars with a program of high quality training from a diverse faculty in both basic and clinical departments. Stanford has a strong reputation for research and our 31 K12 faculty have been successful in obtaining grant support with an average of $1,918,610 in direct cost funding for research ranging from basic immunology, genetics/genomics, and islet cell biology to clinical trials of new therapeutics for diabetes prevention or treatment with diabetes technology. This K12 will provide research and career development training for Pediatric and Adult Endocrinologists in T1D so they can be leaders as physician-scientists. These clinically and research trained K12 scholars will be well positioned to serve as catalysts for multidisciplinary investigations bridging bench-to- bedside science leading to patient centered discoveries. We are confident that with a specific Program to support mentored research in T1D that we will be able to attract the highest caliber of applicants and mentor them to achieve success in academic medicine as physician-scientists.

项目概要斯坦福 K12“培训 1 型糖尿病研究领导者”的首要目标是教育以及儿科和成人内分泌学学术职业研究人员的培训，特别关注 1 型糖尿病 (T1D)。我们的 K12 计划包含三个关键培训组成部分：1) 指导研究。经验，2) 教学指导，以及 3) 指导和职业发展培训。我们项目的显着特点是该项目教师的成就和实力我们以斯坦福大学的研究环境为 K12 培训资助奠定了科学基础。基于我们最近 P30 资助的斯坦福糖尿病研究中心 (SDRC) 的结构以及成功的斯坦福大学糖尿病、内分泌学和代谢 T32 长期培训计划。通过四个战略研究核心提供服务：1) 临床和转化核心；2) 基因组学和分析核心；3）胰岛研究核心；4）免疫监测核心。 SDRC 将 98 名 SDRC 研究人员分为四个广泛的研究“亲和”领域：1) 胰腺和胰岛研究；2) 糖尿病的代谢和信号转导；3) 糖尿病免疫学和移植； K12 糖尿病、生物工程和行为科学将利用现有的 T32、P30 和校园。广泛的学习课程和研究经验，为我们专注于 T1D 的 K12 学者提供以下项目：斯坦福大学基础和临床部门的多元化教师提供高质量的培训。我们的研究声誉以及我们的 31 名 K12 教师已成功获得资助支持平均 1,918,610 美元的直接成本资助用于基础免疫学、遗传学/基因组学、和胰岛细胞生物学到预防糖尿病或治疗糖尿病的新疗法的临床试验该 K12 将为儿童和成人提供研究和职业发展培训。 T1D 内分泌学家因此可以成为临床和研究培训的领导者。 K12 学者将处于有利地位，成为跨学科研究的催化剂，在实验室与实验室之间架起桥梁。我们有信心通过特定的计划来实现以患者为中心的发现。支持 T1D 的研究导师，我们将能够吸引最高素质的申请人和导师他们作为医师科学家在学术医学领域取得成功。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

50 Years Ago in TheJournalofPediatrics: Progress in Pediatric Diabetes Prediction, Management, and Outcomes.

50 年前，《儿科杂志》：儿科糖尿病预测、管理和结果的进展。

DOI：
发表时间：
2021
期刊：
影响因子：
0
作者：
Iklé, Jennifer M;Maahs, David M
通讯作者：
Maahs, David M

Digital Technology for Diabetes.

糖尿病数字技术。

DOI：
10.1056/nejmra2215899
发表时间：
2023-11-30
期刊：
The New England journal of medicine
影响因子：
0
作者：
Michael S. Hughes;Ananta Addala;Bruce Buckingham
通讯作者：
Bruce Buckingham

Feasibility Studies of an Insulin-Only Bionic Pancreas in a Home-Use Setting.

家庭使用的纯胰岛素仿生胰腺的可行性研究。

DOI：
发表时间：
2019
期刊：
影响因子：
0
作者：
Ekhlaspour, Laya;Nally, Laura M;El;Ly, Trang T;Clinton, Paula;Frank, Eliana;Tanenbaum, Molly L;Hanes, Sarah J;Selagamsetty, Rajendranath R;Hood, Korey;Damiano, Edward R;Buckingham, Bruce A
通讯作者：
Buckingham, Bruce A

Safe use of the ketogenic diet in an infant with microcephaly, epilepsy, and diabetes syndrome: a case report.

患有小头畸形、癫痫和糖尿病综合征的婴儿安全使用生酮饮食：病例报告。

DOI：
发表时间：
2023-09-09
期刊：
影响因子：
2.4
作者：
Zegarra, Walter A;Gallentine, William B;Ruzhnikov, Maura R;McAndrews, Catherine A;Gloyn, Anna L;Addala, Ananta
通讯作者：
Addala, Ananta

Weight Management in Youth with Type 1 Diabetes and Obesity: Challenges and Possible Solutions.

患有 1 型糖尿病和肥胖症的青少年的体重管理：挑战和可能的解决方案。