Examining domains of trauma response and their link to chronic pain

检查创伤反应的领域及其与慢性疼痛的联系

• 批准号: 10698022
• 负责人: Jennifer Pierce
• 金额: $ 13.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10698022
• 关键词: Accident and Emergency department; Accidental Injury; Acute; Address; Affect; Affective; American; Area; Award; Characteristics; Computers; Data; Data Analyses; Data Set; Dedications; Development; Distress; Early identification; Emergency department visit; Emotional; Emotions; Environment; Evaluation; Funding; Future; Goals; Health; Intentional injury; Knowledge; Leadership; Link; Longitudinal Studies; Measures; Mediator; Mentored Research Scientist Development Award; Mentorship; Methodology; Methods; Michigan; Modeling; National Institute of Mental Health; Neurobiology; Outcome; Pain; Participant; Patient Self-Report; Patients; Perception; Phenotype; Post-Traumatic Stress Disorders; Psychophysics; Reaction; Recording of previous events; Recovery; Reporting; Research; Research Design; Research Domain Criteria; Research Personnel; Research Proposals; Risk; Risk Factors; Role; Sensory; Series; Social Perception; Social Processes; Statistical Data Interpretation; Stimulus; Surveys; Survivors; Symptoms; Testing; Time; Training; Trauma; Universities; Vehicle crash; Vulnerable Populations; chronic pain; clinical pain; cohort; emotional trauma; experience; experimental study; falls; individualized medicine; lens; pain chronification; pain outcome; pain sensitivity; pain symptom; prevent; programs; psychologic; psychological symptom; response; sexual assault; skill acquisition; skills; social; trauma exposure; trauma symptom; traumatic event

PROJECT SUMMARY/ABSTRACT Physical and emotional trauma are linked to numerous negative health effects, including a nearly three-fold increase in the odds of reporting chronic pain. Research suggests that post-traumatic chronic pain is preceded by at least three classes of factors (i.e., psychological, neurobiological, and social) that might allow for earlier identification of vulnerable individuals. Yet, current data used to elucidate potential mechanisms linking traumatic events to pain development have been limited. Capturing longitudinal data that identifies early risk factors and vulnerabilities to pain is particularly difficult. Additionally, few studies have evaluated the role of social perception and sensitivity to negative social stimuli (i.e., ‘social sensitivity’) as potential mediators linking trauma exposure to physical pain. The current proposal seeks to address these limitations by integrating multiple domains and levels of analysis to examine the impact of traumatic response on the development and persistence of chronic pain. The project will first leverage existing longitudinal and experimental data collected as part of the Advancing Understanding of RecOvery afteR traumA (AURORA) study (NIMH U01MH110925) to explore psychological and neurobiological contributions to post-traumatic pain vulnerability. The project will then expand beyond the data available in AURORA by conducting an experimental study in participants with varying histories of trauma and clinical pain characteristics to examine the associations between social perception and sensitivity, trauma sequelae, and pain. The study will utilize experimental paradigms measuring emotion perception, perspective-taking, and social sensitivity and assess these social processing factors as potential mediators of the association between trauma sequelae and pain characteristics. The association between survey measures of social perception and pain symptoms will also be assessed over time. This research proposal is part of a larger training plan that allows the candidate to develop expertise in trauma and pain, longitudinal data analysis, and experimental methodology; and leadership skills through management of a small study team. The candidate has assembled a mentorship team of experts with extensive expertise in pain phenotyping, trauma, experimental methodology, and statistical analysis. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on the intersection of trauma and pain. It will also provide critical preliminary data for future funding dedicated to advancing our understanding in this critical area of research.

项目概要/摘要 身体和情感创伤与许多负面健康影响有关，其中包括近三倍的负面影响 报告慢性疼痛的几率增加 研究表明，创伤后慢性疼痛先于发生。 至少三类因素（即心理因素、神经生物学因素和社会因素）可能会导致早期 然而，目前的数据用于阐明潜在的联系机制。 捕获识别早期风险的创伤事件的纵向数据有限。 此外，很少有研究评估疼痛的作用。 社会认知和对负面社会刺激的敏感性（即“社会敏感性”）作为潜在的中介因素 当前的提议旨在通过整合来解决这些局限性。 多个领域和层次的分析，以检查创伤反应对发展和发展的影响 该项目将首先利用收集的现有纵向和实验数据。 作为促进创伤后恢复 (AURORA) 研究 (NIMH U01MH110925) 的一部分 该项目将探讨心理和神经生物学对创伤后疼痛脆弱性的影响。 然后通过在 AURORA 中进行实验研究来扩展 AURORA 中可用的数据 不同的创伤史和临床疼痛特征来检查社会因素之间的关联 该研究将利用实验范式。 测量情绪感知、观点采择和社交敏感性并评估这些社交处理 作为创伤后遗症和疼痛特征之间关联的潜在中介因素。 社会认知调查测量与疼痛症状之间的关联也将被评估 该研究计划是一个更大的培训计划的一部分，该计划允许候选人发展专业知识。 创伤和疼痛、纵向数据分析和实验方法以及领导技能； 候选人组建了一个由专家组成的导师团队。 在疼痛表型、创伤、实验方法和统计分析方面拥有丰富的专业知识。 结合密歇根大学丰富的环境，该奖项将为 建立独特的专业知识和独立的研究计划，重点关注 它还将为致力于推进我们的未来资金提供重要的初步数据。 对这个关键研究领域的理解。