Early life household air pollution, metal composition and cardiovascular health: Evidence from GRAPHS

生命早期的家庭空气污染、金属成分和心血管健康：来自图表的证据

基本信息

批准号：
10698134
负责人：
Darby Jack
金额：
$ 58.06万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-07 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10698134
关键词：
12 year old 4 year old 8 year old Accounting Affect Age Air Pollution Anthropometry Arsenic Biological Markers Birth Birth length Blood Pressure Body mass index Cadmium Carbon Monoxide Cardiotoxicity Cardiovascular Diseases Cardiovascular system Cessation of life Child Childhood Cookstove Data Development Diastolic blood pressure Environmental Exposure Environmental Risk Factor Exposure to Fasting Fire - disasters Future Gases Ghana Glucose Grant Growth Health Height Heterogeneity Hour Household Household Air Pollution Infant Intention Intervention Intervention Studies Lead Life Life Cycle Stages Lipids Literature Longitudinal Studies Low Birth Weight Infant Manganese Measurement Measures Mediation Metal exposure Metals Methods Monitor Morbidity - disease rate Nickel Outcome Assessment Persons Petroleum Policies Predisposition Pregnancy Pregnant Women Prevention strategy Public Health Randomized Research Research Project Grants Rest Risk Estimate Risk Reduction Smoke Source Spottings Tobacco smoke Toxic effect Urine Vanadium Weight air monitoring ambient air pollution arm attributable mortality cardiovascular disorder risk cardiovascular health cohort comparison control cooking cost effective cost effective intervention data repository disability-adjusted life years disorder risk evidence base fine particles follow-up improved in utero infancy low and middle-income countries lung health mortality premature prenatal programs response treatment arm urinary

项目摘要

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M DALYs in 2019. The largest proportion of HAP-attributable deaths are due to cardiovascular disease. Establishment of cardiovascular health in childhood is critical to reduce risk for future cardiovascular disease. We hypothesize that early life (prenatal to age 1) exposure to HAP alters cardiovascular development and programs future disease risk. We further hypothesize that the metal composition of air pollution drives toxicity. We propose to build on an existing pregnancy cohort in Ghana – the Ghana Randomized Air Pollution and Health Study, or GRAPHS – to assess how early life air pollution exposure and metals exposures affect cardiovascular health through age 12 years. We will use well-established, validated methods to assess these outcomes. In the long run, our research will help build the evidence base for cost effective interventions to improve health by reducing HAP exposure.

项目概要在低收入和中等收入国家，约 28 亿人每天暴露在烹饪火灾产生的烟雾中，称为家庭空气污染 (HAP)，预计 2019 年导致 230 万人死亡和 9140 万人伤残调整生命年 (DALY)。 HAP 造成的死亡中有一部分是由于心血管疾病造成的。儿童时期的健康对于降低未来心血管疾病的风险至关重要。（产前至 1 岁）暴露于 HAP 会改变心血管发育并规划未来的疾病风险。此外，我们建议以空气污染的金属成分为基础。加纳现有的妊娠队列——加纳随机空气污染与健康研究（GRAPHS）—— 评估生命早期的空气污染暴露和金属暴露如何影响 12 岁之前的心血管健康从长远来看，我们将使用成熟的、经过验证的方法来评估这些结果。将有助于建立具有成本效益的干预措施的证据基础，通过减少 HAP 暴露来改善健康。