The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network

国家药物滥用治疗临床试验网络佛罗里达节点联盟

基本信息

批准号：
10655864
负责人：
Daniel J Feaster
金额：
$ 197.03万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10655864
关键词：
Address Adolescent Adult Budgets Caring Childhood Clinic Clinical Research Clinical Treatment Clinical Trials Network Collaborations Data Data Science Development Dissemination and Implementation Drug abuse Electronic Health Record Family Florida Foundations HIV HIV/HCV Harm Reduction Health system Healthcare Healthcare Systems Hispanic Populations Hospitals Infrastructure Injecting drug user Intervention Leadership Learning Mainstreaming Manuals Medical Mental Health Methods Modeling Patients Population Precision therapeutics Prevention Primary Health Care Procedures Ramp Registries Research Schools Science Site Technology Testing Training Treatment outcome Universities Work base behavioral health bioinformatics tool comorbidity design eHealth experience follow-up health care settings health economics implementation science improved individual response innovation patient population point of care practice-based research network precision medicine screening service delivery stimulant use substance use success treatment response treatment services

项目摘要

PROJECT SUMMARY/ABSTRACT The Florida Node Alliance (FNA) aims to build on our record of success in leading and implementing trials in healthcare settings and integrating substance use into mainstream of healthcare. We propose to bring to the CTN the FNA’s considerable expertise in adolescent treatment, the HIV and HCV care continua in substance- using populations, mental health comorbidities, e-Health, data science, culturalized science, health economics, training, implementation/dissemination, and work with Hispanic populations. The FNA’s research agenda will provide scientific leadership to develop, test, and implement interventions for the full spectrum of substance use in adolescents and adults, and strategies for the integration of SU prevention/screening/treatment services into mainstream adolescent and adult health care. The FNA also aims to apply our expertise in implementation science, data science, and the use of electronic health records (EHRs) to promote learning health care systems that build on precision medicine principles by implementing and refining methods to predict individual response to treatment. Building on a foundation of bidirectional collaboration, the FNA proposes to develop, test, and implement interventions that address the service delivery continuum in the FNA’s clinical and research networks. These networks consist of SUD treatment and general medical settings, health systems, clinical research networks, and practice-based research networks. To achieve its aims, the FNA is proposing an innovative research agenda of concepts that (1) integrate behavioral health and family-focused interventions in pediatric care with the use of e-technologies, (2) deliver integrative models of care for comorbid SU and HIV in hospital settings, (3) address the comorbidities of mental health and stimulant use, (4) use EHR, registry and environmental data to improve treatment precision, and (5) use context and culture to improve treatment outcomes. The FNA proposes to collaborate with other Nodes on the design and implementation of CTN trials and by providing the infrastructure and capabilities required for successful study execution. FNA network partners have demonstrated experience in conducting point of care trials and studies that leverage the use of EHR and claims data. The University of Miami CTSI, University of Florida CTSI, and the Georgia CTSA will bring to the CTN the bioinformatics tools of the CTSA National Consortium. These CTSAs together with partners of the FNA, facilitate access to a diverse patient population of 16+ million patients across numerous settings such as primary care, EDs, hospitals, FQHCs, school-based clinics, SUD treatment, and harm reduction venues.

项目概要/摘要佛罗里达节点联盟 (FNA) 旨在巩固我们在领导和实施试验方面的成功记录。我们建议将医疗保健环境纳入医疗保健主流。 CTN 和 FNA 在青少年治疗、艾滋病毒和丙型肝炎护理方面拥有丰富的专业知识，使用人群、心理健康合并症、电子健康、数据科学、文化科学、卫生经济学、 FNA 的研究议程将包括培训、实施/传播以及与西班牙裔人群的合作。提供科学领导来开发、测试和实施全方位物质的干预措施在青少年和成人中的使用，以及 SU 预防/筛查/治疗服务整合的策略 FNA 还旨在将我们的专业知识应用于实施。科学、数据科学以及使用电子健康记录 (EHR) 来促进学习医疗保健通过实施和完善预测个体的方法，建立在精准医学原则基础上的系统 FNA 建议在双向合作的基础上制定、测试并实施干预措施，解决 FNA 临床和服务中的服务提供连续性问题这些网络包括 SUD 治疗和一般医疗机构、卫生系统、临床研究网络和基于实践的研究网络为了实现其目标，FNA 提议。一个创新的概念研究议程，（1）整合行为健康和以家庭为中心的使用电子技术对儿科护理进行干预，(2) 提供针对共病的综合护理模式医院环境中的 SU 和 HIV，(3) 解决心理健康和兴奋剂使用的合并症，(4) 使用 EHR，登记和环境数据以提高治疗精度，以及（5）利用背景和文化来改善 FNA 建议与其他节点合作设计和实施 CTN 试验并提供成功执行研究所需的基础设施和功能。网络合作伙伴在开展即时护理试验和研究方面展现了丰富的经验，这些试验和研究利用了使用 EHR 和索赔数据。迈阿密大学 CTSI、佛罗里达大学 CTSI 和佐治亚州 CTSA。将向 CTN 带来 CTSA 国家联盟的生物信息学工具以及这些 CTSA。 FNA 的合作伙伴，促进接触众多不同患者群体（超过 1600 万名患者）初级保健、急诊室、医院、FQHC、学校诊所、SUD 治疗和伤害等环境减少地点。