Fox COBRE Phase II Admin Core

Fox COBRE 第二阶段管理核心

基本信息

批准号：
10654735
负责人：
JOSEPH M FOX
金额：
$ 149.82万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10654735
关键词：
Achievement Adjuvant Advisory Committees Area Award Biological Biology Biomedical Research Capsid Career Mobility Cells Centers of Research Excellence Chemicals Communicable Diseases Core Facility Development Disease Educational workshop Enzymes Event Faculty Funding Goals Grant Group Meetings Growth Growth and Development function HIV Human Human Biology Immune response Immunology Infrastructure Lead Leadership Legionnaires&apos Disease Link Lung Macromolecular Complexes Malignant Neoplasms Manuscripts Maps Mentors Messenger RNA Microbiology Modeling Modification Molecular Molecular Probes Pathway interactions Phase Pilot Projects Postdoctoral Fellow Preparation Publications Regulation Research Research Personnel Research Training Resources Series Structure Students Therapeutic Training Tuberculosis Universities Virus Vocational Guidance Work Writing career development chemical synthesis cohort drug discovery endopeptidase Clp experience faculty mentor flexibility formative assessment human disease meetings member nanoparticle pathogenic bacteria programs recruit research and development small molecule success support network tool vaccine development

项目摘要

Project Summary Administrative Core This Phase II COBRE will continue our center’s work to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approaches for understanding small molecule interactions with complex macromolecular targets. Building on the infrastructure and successes of Phase I, our COBRE will develop new chemical biology tools for understanding the cellular and molecular mechanisms that bacterial pathogens use to survive and replicate inside host cells, molecular probes that can be used to understand Clp protease targets of infectious diseases, tools to map and understand the regulation of reversible mRNA modification by a ‘methyl eraser’ enzyme linked to the progression of human cancers, molecularly-defined nanoparticle adjuvants that yield specific immune responses in the lung to advance inhalable vaccine development, and computational approaches to elucidate the mechanisms by which small molecules regulate the structure and function of virus capsids. The goals of the Administrative Core are (1) Development of the administrative, fiscal and scientific aspects of the proposed COBRE, including establishment of a leadership team and a hiring plan; (2) Implementation of summative and formative evaluation strategies by the Leadership Team, an Internal Advisory Committee (IAC), mentors, and an External Advisory Committee (EAC); (3) Implementation of a Career Guidance Plan that enables faculty to develop successful research programs and to attract funding for their work; (4) Development of research, training & career development goals and capabilities. A plan for hiring and retaining successful faculty is detailed as is a plan for transitioning investigators to independent status with continued access to core facilities and participation in COBRE sponsored events.

项目概要行政核心第二阶段 COBRE 将继续我们中心的工作，开发用于探测生物学的分子方法，以发现并应用新的化学生物学工具来研究与疾病相关的生物途径，以及开发计算方法来理解小分子与复杂分子的相互作用基于第一阶段的基础设施和成功，我们的 COBRE 将开发新的大分子目标。用于了解细菌病原体利用的细胞和分子机制的化学生物学工具在宿主细胞内存活和复制，分子探针可用于了解宿主细胞的 Clp 蛋白酶靶标传染病、绘制和理解“甲基”可逆 mRNA 修饰调节的工具橡皮擦酶与人类癌症的进展有关，分子定义的纳米颗粒佐剂在肺部产生特异性免疫反应，以推进可吸入疫苗的开发和计算阐明小分子调节病毒结构和功能机制的方法衣壳。行政核心的目标是 (1) 发展行政、财政和科学方面拟议的 COBRE，包括建立领导团队和招聘计划 (2) 实施；领导团队、内部咨询委员会 (IAC) 制定总结性和形成性评估策略，导师和外部咨询委员会 (EAC)； (3) 实施职业指导计划： (4) 发展使教师能够开发成功的研究项目并为其工作吸引资金；研究、培训和职业发展目标和能力的计划。详细介绍了教师的情况以及将调查人员转变为独立地位并继续接触核心的计划设施和参与 COBRE 赞助的活动。