2009 Polyamines GRC & GRS

2009 聚胺GRC

• 批准号: 7672110
• 负责人: Patrick M Woster
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7672110
• 关键词: Anabolism; Antineoplastic Agents; Antiparasitic Agents; Area; Bacteria; Bacterial Infections; Cell physiology; Collaborations; Development; Disease; Epigenetic Process; Eukaryotic Cell; Genetic; Genetic Transcription; Homeostasis; Link; Malignant Neoplasms; Mammalian Cell; Metabolic Pathway; Metabolism; New Hampshire; Organism; Pathway interactions; Physiological; Polyamines; Protozoa; Research; Research Personnel; Resort; Role; Scientist; Students; Therapeutic; Therapeutic Agents; Translations; Work; Yeasts; cell growth; drug development; inhibitor/antagonist; interest; meetings; multidisciplinary; novel therapeutics; polycation; posters; protein degradation; public health relevance; small molecule; symposium

DESCRIPTION (provided by applicant): Since 1975, the Polyamine GRC has been a multidisciplinary conference focused on the polyamine metabolic pathway, the role of polyamines in cellular homeostasis and the development of small molecules that modulate polyamine metabolism as potential therapeutic agents. This meeting is widely regarded as the pre-eminent venue for the presentation and discussion of polyamine research. The Polyamine Gordon conference will be held at the Waterville Valley Resort in Waterville Valley, New Hampshire from June 21-26, 2009. Polyamines are small organic polycations found in virtually all prokaryotic and eukaryotic cells. Despite their importance and ubiquitous occurrence, the cellular functions of polyamines are not fully understood. Polyamines are closely linked to cell growth, and as such inhibitors of polyamine biosynthesis are promoted as anti-proliferative agents. Polyamines are highly regulated at the levels of transcription, translation and protein turnover. Thus the field brings together researchers interested in the physiological role of polyamines in a wide array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications such as cancer and parasitic or bacterial infection. It is becoming increasingly clear that polyamines have unique roles in different organisms, and further that the biosynthetic and catabolic pathways, as well as the associated regulatory mechanisms, vary widely among different species. The 2009 Polyamine Gordon Research Conference will feature presentations from scientists in the forefront of polyamine research in the areas of anticancer drug development and the development of antiparasitic agents. In addition, the meeting will include presentations outlining the role of polyamine metabolism in cellular homeostasis, with an emphasis on basic mechanisms of genetic, epigenetic and physiological control. The meeting will be composed of 30 minute talks followed by a 10 minute discussion period, and two poster sessions. It will also include short talks by students or postdocs whose work has been chosen from the poster presentations by the organizing committee. In order to further encourage the participation of student and postdoctoral scientists in the meeting, the Polyamine GRC will be held in conjunction with the second Gordon-Kenan Graduate Research Seminar (GKGRS) on Polyamines. The GKGRS will be held from June 20-21, and students and postdocs participating in the GKGRS will be expected to also attend the regular GRC meeting, which immediately follows. Public Health Relevance: Polyamines are small organic polycations that are found in virtually all prokaryotic and eukaryotic cells, and that are absolutely required for normal cellular function. An understanding of normal polyamine metabolism is critical to the understanding of cellular function, and aberrant polyamine metabolism and function are regarded as targets for the discovery of new therapeutic agents for cancer and other diseases. The Polyamines Gordon Research Conference, the pre-eminent scientific meeting in the field, provides a forum for internationally known researchers to discuss their research results and maintain active scientific collaborations.

描述（由申请人提供）：自1975年以来，多胺GRC一直是一个多学科会议，重点是多胺代谢途径，多胺在细胞稳态中的作用以及将多胺代谢作为潜在治疗剂调节的小分子的发展。这次会议被广泛认为是对多胺研究的介绍和讨论的杰出场所。多胺戈登会议将于2009年6月21日至26日在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行。多胺是在几乎所有原核生物和真核细胞中发现的小有机多阳离子。尽管它们的重要性和普遍存在的发生，但尚未完全了解多胺的细胞功能。多胺与细胞生长密切相关，因此，多胺生物合成的抑制剂被促进为抗增殖剂。在转录，翻译和蛋白质周转的水平上，多胺受到高度调节。因此，该领域汇​​集了对多胺在多种生物（哺乳动物细胞，酵母，原生动物和细菌）中的生理作用感兴趣的研究人员以及对治疗应用感兴趣的研究人员，例如癌症，寄生或细菌感染。越来越清楚的是，多胺在不同的生物体中具有独特的作用，进一步的生物合成和分解代谢途径以及相关的调节机制在不同物种之间差异很大。 2009年的多胺戈登研究会议将在抗癌药物开发和抗寄生虫的开发领域的最前沿科学家的演讲。此外，会议将包括介绍多胺代谢在细胞稳态中的作用，重点是遗传，表观遗传和生理控制的基本机制。会议将由30分钟的会谈组成，然后进行10分钟的讨论期和两个海报会议。它还将包括学生或博士后的简短会谈，他们的工作是由组织委员会从海报演讲中选择的。为了进一步鼓励学生和博士后科学家参加会议，多胺GRC将与第二次戈登 - 肯南研究生研究研讨会（GKGRS）一起举行。 GKGRS将于6月20日至21日举行，参加GKGRS的学生和博士后还将参加正常的GRC会议，即将举行。 公共卫生相关性：多胺是小的有机多阳离子，在几乎所有原核和真核细胞中都发现，这绝对是正常细胞功能所必需的。对正常多胺代谢的理解对于对细胞功能的理解至关重要，异常的多胺代谢和功能被认为是发现新的癌症和其他疾病治疗剂的靶标。该领域杰出的科学会议戈登研究会议为国际知名的研究人员提供了一个论坛，以讨论其研究结果并维持积极的科学合作。