Eighth International Workshop on Molecular Aspects of Myeloid Stem Cell Developme

第八届骨髓干细胞发育分子方面国际研讨会

• 批准号: 7673194
• 负责人: Steven Jules Ackerman
• 金额: $ 1.4万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673194
• 关键词: Blood Cells; Cell Cycle; Clinic; Clinical; Communication; Development; Disease; Dysmyelopoietic Syndromes; Educational workshop; England; Epigenetic Process; Europe; Fertilization; Gene Mutation; Gene Targeting; Genes; Goals; Grant; Hematopoiesis; Hematopoietic; Hematopoietic stem cells; Individual; International; Japan; Malignant - descriptor; Modification; Molecular; Mus; Mutation; Myeloid Progenitor Cells; Myelopoiesis; Oral; Participant; Pathogenesis; Patients; Postdoctoral Fellow; Published Comment; RUNX1 gene; Regulation; Research; Research Personnel; Research Project Grants; Role; Sampling; Schedule; Scientist; Sequence Analysis; Series; Signal Transduction; Stem Cell Development; Stem cells; Therapeutic; Transducers; Translocation Breakpoint; Work; abstracting; combinatorial; graduate student; leukemia; leukemogenesis; meetings; posters; public health relevance; stem cell biology; symposium; transcription factor

DESCRIPTION (provided by applicant): This conference grant is for the 8th biennial workshop on "Molecular Aspects of Myeloid Stem Cell Development and Leukemia." This 8th workshop, in a series held since 1995, is scheduled for May 10-13, 2009 at the Loews Annapolis hotel in Annapolis, MD. The workshop hosts ~50 speakers, with a total of ~100 participants. Leukemia is a disease of hematopoietic stem cells that undergo a block in differentiation and a deregulated expansion. The workshop focuses on genes located at translocation breakpoints in leukemia such as AML1, TEL, RARa, and MLL, and on genes aberrantly expressed due to epigenetic alterations or function abnormally due to mutations. Mutations or abnormal levels of these factors are causally related to leukemogenesis. Murine gene-targeting studies and sequence analyses of patient samples show the critical importance of these same genes for normal hematopoiesis. The functions of these factors are combinatorial in hematopoietic development, and the complexity of interactions within overlapping networks makes it difficult for single investigators to gain wide scientific and clinical perspective to understand their roles in normal hematopoiesis and leukemogenesis. The goal is to bring together investigators with expertise in complementary aspects of stem cell biology, normal myelopoiesis and leukemia. Basic and clinician-scientists from the USA, England, Europe and Japan come together to discuss their latest findings on stem cells and hematopoietic regulators, e.g. transcription factors, including those who work on myelodysplastic syndrome and leukemia mechanisms and therapeutics, signal transducers and cell cycle components dysregulated through genetic mutations or epigenetic modifications. The aim is exchange of information through informal presentations and discussions. Young investigators (graduate students, postdoctoral fellows) comprise ~50% of participants and have the opportunity to present their work as posters or oral talks. Participants achieve greater understanding of the critical factors that regulate lineage specification and malignant hematopoiesis, and their relevance in the clinic in terms of leukemia. The workshop uniquely brings together basic scientist, clinician-investigators, and junior investigators in a manner that truly promotes communication and open exchange of ideas, unpublished results, cross-fertilization and collaborative research between scientists working on normal and leukemic stem cells and myeloid development, along with translational leukemia research and leukemia therapeutics. (End of Abstract)

描述（由申请人提供）： 这次会议赠款是针对“髓样干细胞发育和白血病的分子方面”的第八个双年展研讨会。自1995年以来举行的系列活动中的第八届研讨会定于2009年5月10日至13日在马里兰州安纳波利斯的Loews Annapolis Hotel举行。该研讨会主持约50名演讲者，共有约100名参与者。白血病是造血干细胞的疾病，在分化和放松管制的扩张中经历了障碍。该研讨会的重点是在白血病（例如AML1，TEL，RARA和MLL）中位于易位断点的基因，以及由于突变而异常表达的基因，因此异常表达。这些因素的突变或异常水平与白血病有关。鼠类基因靶向研究和患者样品的序列分析表明，这些相同基因对正常造血的重要性至关重要。这些因素的功能是组合在造血发育中的组合，重叠网络中相互作用的复杂性使单个研究者很难获得广泛的科学和临床观点，无法了解其在正常造血和白血病发生中的作用。目的是将研究人员汇集到具有干细胞生物学，正常骨髓病和白血病的互补方面方面的专业知识。来自美国，英格兰，欧洲和日本的基础和临床医生科学家聚集在一起，讨论他们关于干细胞和造血调节剂的最新发现，例如转录因子，包括从事骨髓增生综合征和白血病机制和治疗剂，信号换能器和细胞周期成分通过遗传突变或表观遗传学修饰失调的人。目的是通过非正式演示和讨论交换信息。年轻的调查人员（研究生，博士后研究员）占参与者的约50％，并有机会作为海报或口头演讲介绍他们的作品。参与者对调节谱系规范和恶性造血的关键因素有了更大的了解，以及在白血病方面的相关性。该研讨会独特地汇集了基础科学家，临床医生评估者和初级研究人员，以一种真正促进了思想的沟通和开放交流，未发表的结果，跨效率，交叉施肥和合作研究的方式，以及从事正常和白血病干细胞和髓样发展的科学家之间的研究，以及转化性白血病研究和白血病研究和白血病治疗。 （抽象的结尾）