2009 Cell Biology of Metals Gordon Conference

2009年金属细胞生物学戈登会议

• 批准号: 7743607
• 负责人: Valeria C Culotta
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7743607
• 关键词: Biological; Cells; Cellular biology; Collaborations; Copper; Discipline; Disease; Drug Metabolic Detoxication; Elements; Fund Raising; Goals; Hematopoietic; Homeostasis; Human; Indium; Ions; Iron; Life; Light; Metals; Microbe; Minority; Monitor; Nerve Degeneration; Oxidative Stress; Pathogenesis; Research Personnel; Sampling; Science; System; Toxic effect; Woman; Zinc; extracellular; human disease; kidney vascular structure; meetings; microbial; nutrition; posters; symposium; trafficking

DESCRIPTION (provided by applicant): The Cell Biology of Metals Gordon Conference provides a forum for which bioinorganic chemists, metallobiologists and clinicians for metal related disorders all meet and discuss the latest advances in understanding metal homeostasis at the single cell level. The complexity of how metal ions are taken up from the extracellular milieu and appropriately trafficked in a cell without causing toxicity is a field of growing importance. An increasing number of disorders are being attributed to disruptions in cellular metal homeostasis. As such, the goal of the 2009 Cell Biology of Metals Gordon conference is to present the latest breakthroughs in the cell biology of metal transport, trafficking and detoxification and how these findings relate to human disease. Our Specific Aims are: 1) To organize a conference that focuses on the cell biology of metals and to raise funds to support the attendance of junior investigators in this field; 2) To promote exchange of scientific ideas and collaborations among diverse investigators that may otherwise not interact; 3) To encourage and promote young investigators, women and minorities in the conference. Talks from leaders in the field will cross multiple disciplines, from the very basic bioinorganic to applied studies of metals in diseases. Sample sessions include: monitoring metals in cells, metals and oxidative stress, and metals in microbial pathogenesis, neurodegeneration and hematopoietic disorders. In addition, new discoveries in understanding mechanisms of metal ion selectivity and metal co-factor assembly will be presented. In all sessions, emphasis will be placed on discoveries made at cell biology level. Talks will be from invited speakers and from selected poster presentations, with much promotion of junior investigators in the field. Topics will expand from microbes to humans, cutting across multiple elements of biological importance. Metal ions such as copper, zinc and iron are important elements in nutrition. However, when present in excess these same elements are quite toxic and have been attributed to various human disorders including diseases of the nervous, cardio vascular and renal systems. The science to be presented at the Cell Biology of Metals Gordon conference promises to shed new important light into the mechanisms by which cells manage these metals that both potentially toxic and essential for life.

描述（由申请人提供）：金属戈登会议的细胞生物学提供了一个论坛，为金属相关疾病的生物无机化学家，金属生物学家和临床医生都符合并讨论在单细胞水平上了解金属稳态的最新进展。金属离子如何从细胞外环境中占据并在细胞中适当运输而不会引起毒性的复杂性是一个日益重要的领域。越来越多的疾病归因于细胞金属稳态的干扰。因此，2009年金属戈登会议的细胞生物学的目标是介绍金属运输，贩运和排毒细胞生物学的最新突破以及这些发现与人类疾病的关系。我们的具体目的是：1）组织一次会议，该会议侧重于金属的细胞生物学，并筹集资金以支持该领域的初级研究人员的出席； 2）促进不同研究者之间可能不会相互作用的科学思想和合作的交流； 3）在会议上鼓励和促进年轻的调查员，妇女和少数民族。该领域的领导者的谈判将跨越多个学科，从非常基本的生物无机性到对疾病金属的应用研究。样品会话包括：细胞中的金属，金属和氧化应激中的金属，以及微生物发病机理，神经退行性和造血性疾病的金属。此外，将提出理解金属离子选择性和金属co因子组件机制方面的新发现。在所有课程中，都将重点放在细胞生物学水平的发现上。会谈将来自受邀演讲者和选定的海报演示，并在该领域进行了大量促进初级调查人员的晋升。主题将从微生物扩展到人类，从而跨越了生物学重要性的多个要素。 铜，锌和铁等金属离子是营养中的重要元素。但是，当出现过多的相同元素时，这些元素具有很大的毒性，并且归因于各种人类疾病，包括神经，心脏血管和肾脏系统的疾病。在金属戈登会议的细胞生物学上介绍的科学有望将新的重要光赋予细胞管理这些金属的机制，这些金属既有可能有毒又对生命必不可少。