Validation of a Standardized Diagnostic Interview for Epilepsy

癫痫标准化诊断访谈的验证

• 批准号: 7787638
• 负责人: RUTH OTTMAN
• 金额: $ 8.02万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7787638
• 关键词: Address; Age; Agreement; Area; Classification; Clinical; Collection; Communities; Computer Assisted; Consent; Data; Diagnosis; Diagnostic; Electroencephalography; Epidemiologic Studies; Epidemiology; Epilepsy; Etiology; Failure; Focal Seizure; Gold; Incidence; International; Interview; Interviewer; Investigation; Medical Records; Mental disorders; Minnesota; Neurologic Examination; Online Systems; Patients; Principal Investigator; Recording of previous events; Research; Residencies; Resources; Savings; Seizures; Symptoms; Syndrome; System; Telephone; Telephone Interviews; Time; Training; Validation; Validity and Reliability; base; clinical Diagnosis; computerized; genetic epidemiology; improved; instrument; nervous system disorder; neuroimaging; population based; public health relevance; tool; validation studies

DESCRIPTION (provided by principal investigator): Standardized tools for clinical diagnosis and classification are essential for consistency in epidemiologic studies, and are especially important for epilepsy because diagnosis and classification are largely based on patient history. Despite the importance of this problem, however, few tools have been developed for standardized collection of clinical information in the epilepsies. In the late 1980's we created a telephone-administered semistructured Epilepsy Diagnostic Interview for clinical classification. The original instrument had good inter-rater reliability and validity for distinguishing between generalized and partial seizures. However, since these early validation studies, we have made major revisions to the instrument to refine our ability to characterize seizure symptoms and thereby improve classification. In the current study we propose to validate this revised instrument and make it available to the research community in a web-based computerized telephone interview format. The data for validation will be from a population-based investigation using Rochester Epidemiology Project resources, the Genetic Epidemiology of Seizure Disorders in Rochester (GESDR) study. GESDR included all Rochester residents born in 1920 or later with incidence of unprovoked seizures from 1935-1994. For each of these subjects, two expert epileptologists carried out a comprehensive review of all medical record information from onset of seizures to last residency in the Rochester area (including seizure descriptions, EEG, neuroimaging, treatment history, etc.) and rendered a final epilepsy diagnosis and classification based on current ILAE criteria. Independently of the medical record review, we administered our current diagnostic interview to each surviving subject who consented, and the same epileptologists reviewed the interview data and rendered a diagnosis and classification based on interview data alone. In the validation study we will assess agreement between these two diagnoses, using the medical record diagnosis as the gold standard. PUBLIC HEALTH RELEVANCE: This project will evaluate the accuracy of clinical classification of epilepsy based on information collected in a standardized telephone interview. It will also produce a web-based computer-assisted telephone interview version of the validated interview. This should facilitate the conduct of epidemiologic research on the causes and consequences of epilepsy at a significant savings of time and money.

描述（由主要研究者提供）：用于临床诊断和分类的标准化工具对于流行病学研究的一致性至关重要，对于癫痫尤其重要，因为诊断和分类很大程度上基于患者病史。尽管这个问题很重要，但是很少开发用于标准化癫痫中临床信息的工具。在1980年代后期，我们创建了一次电话管理的半结构化癫痫诊断访谈，以进行临床分类。原始仪器具有良好的评估者间可靠性和有效性，可区分广义和部分癫痫发作。但是，由于这些早期验证研究，我们已经对工具进行了重大修改，以完善我们表征癫痫发作症状并从而改善分类的能力。在当前的研究中，我们建议以基于网络的计算机电话访谈格式验证该修订后的工具，并将其提供给研究社区。验证的数据将来自使用罗切斯特流行病学项目资源的基于人群的研究，罗切斯特（GESDR）研究中癫痫发作疾病的遗传流行病学。 GESDR包括1920年或更晚出生的所有罗切斯特居民，1935年至1994年的无端癫痫发作。对于这些主题，两名专家癫痫学家对从癫痫发作到罗切斯特地区的最后居住（包括癫痫发作，脑电图，脑电图，神经影像学，治疗史等）进行了全面的审查，并进行了最终的癫痫病基于当前ILAE标准的诊断和分类。我们与医疗记录审查无关，我们对同意同意的每个尚存的主题进行了当前的诊断访谈，同一癫痫学家审查了访谈数据，并仅基于访谈数据就进行了诊断和分类。在验证研究中，我们将使用病历诊断作为黄金标准来评估这两个诊断之间的一致性。 公共卫生相关性：该项目将根据标准化电话采访中收集的信息评估癫痫临床分类的准确性。它还将生成基于网络的计算机辅助电话采访版本的经过验证的访谈。这将有助于对癫痫病的原因和后果的流行病学研究进行大量节省的时间和金钱。