East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium

东非国际流行病学数据库评估艾滋病 (IeDEA) 区域联盟

• 批准号: 10652544
• 负责人: AGGREY SEMWENDERO SEMEERE
• 金额: $ 339.8万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-05 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10652544
• 关键词: 2019-nCoV; AIDS related cancer; Achievement; Acquired Immunodeficiency Syndrome; Address; Adolescent and Young Adult; Affect; Africa; Behavioral; COVID-19; COVID-19 pandemic; Caring; Cervical; Clinic; Clinical; Collaborations; Communities; Country; Data; Data Sources; Databases; Dermatology; Development; Diagnosis; Disease; Environment; Epidemiology; Evolution; Funding; Gender; Genetic; Geography; Goals; Government; Grant; HIV; HIV/AIDS; Health; Healthcare; Home; Image; Infant; International; Joints; Kaposi Sarcoma; Kenya; Knowledge; Learning; Liver diseases; Longevity; Lung; Machine Learning; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measures; Mental Depression; Mental Health; Methodology; Methods; Movement; Newborn Infant; Operations Research; Outcome; Patient-Focused Outcomes; Patients; Persons; Policies; Pregnancy; Public Health; Research; Resource-limited setting; Risk Factors; Sampling; Sentinel; Statistical Methods; Structure; Tanzania; Technology; Telemedicine; Treatment outcome; Tuberculosis; Uganda; United Nations; Viral; age group; antiretroviral therapy; cancer diagnosis; cardiovascular risk factor; care outcomes; co-infection; cohort; comorbidity; contextual factors; eHealth; experience; implementation evaluation; implementation research; insight; new technology; novel; post-COVID-19; programs; scale up; substance use; syndemic; telehealth; tool; treatment guidelines; treatment program; treatment strategy

Project Summary/Abstract: Our primary goal continues to be the provision of answers to questions that clinicians, governments, programs and international organizations consider central to the evolution and sustainability of their long term HIV care and treatment strategies for achieving the UNAIDS 2030 targets of 95-95-95 in the midst of the SARS-CoV-2 pandemic and changes in public health funding priorities. Our central hypothesis is that retention in the HIV care cascade and treatment outcomes are influenced by patient-level demographic, clinical, developmental, and behavioral factors, as well as, factors within the ambient health care and broader contextual environment. We will leverage our strengths, including robust working relationships with HIV treatment programs, a substantial harmonized regional database, plus broad experience in sampling-based methodologies and novel analytical approaches. Over the course of this research we will: SA-1: Describe movement through the HIV care cascade with a focus on identifying broader and health care environment contextual factors that influence optimal retention in care and viral suppression, in the face of global disruption due to the COVID-19 pandemic and changes in donor funding priorities. The Post COVID-19 Double-Sampling Cohort (Post COVID) will address the impact of broader contextual factors (COVID-19) while the Telehealth and Structural Adaptations project will address the impact of health care structure. SA-2: Examine the impact of developmental stage and behavioral factors on retention in the cascade and subsequent outcomes. The multiregional Adolescent and Young Adult Network of IeDEA (AYANI) and regional Measuring Adverse Pregnancy and Newborn Congenital Outcomes (MANGO) cohorts will assess the impact of developmental stage on the cascade, while the Syndemics cohort will address the impact of mental health on the cascade.SA- 3: Examine the immediate and long-term outcomes of people diagnosed with Tuberculosis (TB) with a focus on identifying and addressing factors associated with patient outcomes. The multiregional TB Sentinel Research Network (TB-SRN) will focus on understanding TB outcomes and long-term pulmonary complications including associated factors. SA-4: Explore the use of new technologies, including eHealth and machine (deep) learning to diagnose and manage HIV-associated cancers with a focus on Kaposi’s Sarcoma (KS) and Cervical Cancer. The KS Project will assess implementation of a Dermatology Telehealth Program and the Cervical Cancer Project will assess the implementation of cervical image capture with machine learning for cancer diagnoses and management. SA-5: Examine the epidemiology of NCD comorbidities and ART complications with a focus on the oldest and youngest-age groups affected by HIV. The multi-regional Sentinel Research Network (SRN) will address non-communicable diseases in people living with HIV (PLHIV) > 40 years and the regional MANGO Cohort will address complications of ART/HIV exposure on HIV-Exposed Infants.

项目摘要/摘要： 我们的首要目标仍然是为封建政府、 计划和国际组织认为对其长期发展和可持续性至关重要 艾滋病毒护理和治疗策略，以实现联合国艾滋病规划署 2030 年 95-95-95 目标 SARS-CoV-2 大流行和公共卫生资金优先事项的变化我们的中心假设是： 艾滋病毒护理级联的保留和治疗结果受到患者人口统计的影响， 临床、发育和行为因素，以及环境卫生保健和更广泛的因素 我们将利用我们的优势，包括在艾滋病毒领域开展强有力的工作。 治疗方案、大量统一的区域数据库以及基于抽样的广泛经验 在本研究过程中，我们将： SA-1：描述。 通过艾滋病毒护理级联运动，重点是确定更广泛的卫生保健环境 面对全球混乱，影响护理和病毒抑制最佳保留的背景因素 由于 COVID-19 大流行和捐助者资助优先事项的变化，Covid-19 后的双重抽样。 队列（新冠疫情后）将解决更广泛的背景因素 (COVID-19) 的影响，而远程医疗 结构调整项目将解决医疗保健结构的影响：检查影响。 发育阶段和行为因素对级联保留和后续结果的影响。 IeDEA (AYANI) 多区域青少年和年轻人网络和区域不利衡量 妊娠和新生儿先天性结局 (MANGO) 队列将评估发育的影响 级联阶段，而 Syndemics 队列将解决心理健康对级联的影响。SA- 3：检查被诊断患有结核病 (TB) 的人的近期和长期结果 专注于识别和解决与患者结果相关的因素。 研究网络 (TB-SRN) 将专注于了解结核病结果和长期肺结核 SA-4：探索新技术的使用，包括电子医疗保健。 和机器（深度）学习来诊断和管理与艾滋病毒相关的癌症，重点是卡波西氏症 肉瘤 (KS) 和宫颈癌。 KS 项目将评估皮肤科远程医疗的实施情况。 计划和宫颈癌项目将评估宫颈图像捕获的实施情况 用于癌症诊断和管理的机器学习 SA-5：检查 NCD 的流行病学。 合并症和 ART 并发症，重点关注受艾滋病毒影响的最年长和最年轻的年龄组。 多区域哨点研究网络（SRN）将解决人们的非传染性疾病问题 HIV 感染者 (PLHIV) > 40 岁，区域 MANGO 队列将解决 ART/HIV 暴露的并发症 关于感染艾滋病毒的婴儿。

项目成果

Semiparametric regression on cumulative incidence function with interval-censored competing risks data.

使用区间删失竞争风险数据对累积发生率函数进行半参数回归。

• 发表时间: 2017-10-15
• 影响因子: 2
• 作者: Bakoyannis, Giorgos;Yu, Menggang;Yiannoutsos, Constantin T
• 通讯作者: Yiannoutsos, Constantin T

Changing forms of HIV-related stigma along the HIV care and treatment continuum in sub-Saharan Africa: a temporal analysis.

撒哈拉以南非洲艾滋病毒护理和治疗连续体中与艾滋病毒相关的耻辱形式的变化：时间分析。

• 发表时间: 2017-07
• 影响因子: 3.6
• 作者: Bonnington, O;Wamoyi, J;Ddaaki, W;Bukenya, D;Ondenge, K;Skovdal, M;Renju, J;Moshabela, M;Wringe, A
• 通讯作者: Wringe, A

Cascade of care for HIV-seroconverters in rural Tanzania: a longitudinal study.

坦桑尼亚农村地区艾滋病毒血清转化者的级联护理：一项纵向研究。

• 发表时间: 2020
• 影响因子: 1.7
• 作者: Colombe, Soledad;Machemba, Richard;Mtenga, Baltazar;Lutonja, Peter;Safari, Wende;Beard, James;Downs, Jennifer A;Urassa, Mark;Todd, Jim;Changalucha, John
• 通讯作者: Changalucha, John

Relating CYP2B6 genotype and efavirenz resistance among post-partum women living with HIV with high viremia in Uganda: a nested cross-sectional study.

乌干达高病毒血症感染艾滋病毒产后妇女的 CYP2B6 基因型与依非韦伦耐药性的关系：一项巢式横断面研究。

• 发表时间: 2023-03-31
• 作者: Buzibye, Allan;Wools;Olagunju, Adeniyi;Twinomuhwezi, Ellon;Yiannoutsos, Constantin;Owen, Andrew;Neary, Megan;Matovu, Joshua;Banturaki, Grace;Castelnuovo, Barbara;Lamorde, Mohammed;Khoo, Saye;Waitt, Catriona;Kiragga, Agnes
• 通讯作者: Kiragga, Agnes

Implementation and operational research: evaluating outcomes of patients lost to follow-up in a large comprehensive care treatment program in western Kenya.

实施和业务研究：评估肯尼亚西部大型综合护理治疗计划中失访患者的结果。

• 发表时间: 2015-04-01
• 作者: Rachlis, Beth;Ochieng, Daniel;Geng, Elvin;Rotich, Elyne;Ochieng, Vincent;Maritim, Beryl;Ndege, Samson;Naanyu, Violet;Martin, Jeffrey N;Keter, Alfred;Ayuo, Paul;Diero, Lameck;Nyambura, Monicah;Braitstein, Paula
• 通讯作者: Braitstein, Paula