Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease

社区健康中心：解决马里兰州地区疾病的环境决定因素

基本信息

批准号：
10652256
负责人：
Marsha Wills-Karp
金额：
$ 138.98万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-24 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10652256
关键词：
Address Affect Allergens Animal Feed Attention Baltimore Big Data Bioinformatics Biological Biometry Center for Translational Science Activities Chemicals Cities Climate Clinical Communication Communities Community Health Core Facility Data Decision Making Development Discipline Disease District of Columbia Educational workshop Environmental Exposure Environmental Health Environmental Risk Factor Exposure to Faculty Federal Government Fostering Funding Future Gases Health Health Policy Health Promotion Health Sciences Human In Vitro Individual Industrialization Industry Investigation Knowledge Laboratories Leadership Link Local Government Maryland Mentors Metals Mission Modeling National Institute of Environmental Health Sciences Natural Gas Neighborhood Health Center Neurologic Outcome Particulate Pennsylvania Personal Satisfaction Policies Polychlorinated Biphenyls Population Population Study Positioning Attribute Predisposition Prevention Production Public Health Public Health Practice Research Research Design Research Personnel Risk Assessment Scholars Program Science Scientist Source Strategic Planning Strategic vision Structure Technology Time Training Translating Translational Research Translations Universities Urban Developments Vulnerable Populations Washington adverse outcome built environment cardiorespiratory fitness career development cohort college community engaged research community engagement data to knowledge disorder prevention environmental justice evidence base health determinants health science research human subject improved in vivo member metabolomics multidisciplinary nervous system disorder response skills social translational engagement translational pipeline vapor vulnerable community

项目摘要

ABSTRACT (OVERALL) The Johns Hopkins University (JHU) proposes the creation of the Center for Community Health: Addressing Regional Maryland Environmental Determinants of Diseases (CHARMED). The strategic vision of the Center is to serve as the nexus of community-engaged environmental research at JHU and in the Maryland region (Washington DC, Baltimore (referred to as CHARM City) and Pennsylvania) by providing focus, research, and leadership for promotion of transformative environmental health science research that will improve human health. The overarching mission is to understand how exposures to environmental factors cause adverse health outcomes and then to translate these findings into action to protect and promote the health and well-being of vulnerable communities in the Maryland region. This mission has been informed by and will continue to be guided by strong partnerships between community leaders and CHARMED members (59) drawn from the JHU and the University of Maryland at College Park. The synergistic combination of basic, population and community- engagement scientists within CHARMED promotes translational research that addresses fundamental questions and translates knowledge into action to have a major impact on human health in the Maryland region, consistent with the NIEHS Strategic Plan. Our mission is accomplished through five aims. Aim 1: Advance translational environmental health research that will improve community health outcomes in the Maryland region as it relates to the thematic foci of the Center. The Thematic Research Groups are: 1) Cardiorespiratory Health and Airborne Contaminants; 2) Chemical Mixtures and Emerging Contaminants, and Health; 3) Community, Social, and Environmental Determinants of Health; and 4) Neurological Health. Aim 2. Promote translation of data to knowledge to action by creating and strengthening strategic partnerships with communities and stakeholders to address environmental health challenges and help set the research agenda of CHARMED using community- engaged research approaches (Community Engagement Core). Aim 3. Establish and support a facility core structure [Integrated Health Sciences Facility Core (IHSFC), and Exposure Characterization and Modeling Facility Core (ECMC)] that enables the mission. The IHSFC will provide assistance with human subject study design, and employ biostatistical, big data, and bioinformatic analyses and integrate “omics” including metabolomics data to predict adverse outcomes. Aim 4. Build capacity in environmental health through a comprehensive strategy that includes fostering (career development, Core Workshops), and supporting (ESI Mentored Scholars Program, pilot funds, access to facility cores) both early stage and senior investigators conducting community environmental health research for the first time. Harnessing the scientific capacity of the Center will facilitate translation of the Center’s research findings into evidence-based approaches for environmental exposure mitigation and disease prevention to improve human health in Maryland and beyond.

摘要（总体）约翰霍普金斯大学 (JHU) 提议创建社区健康中心：解决马里兰州地区疾病环境决定因素 (CHARMED) 该中心的战略愿景。是约翰霍普金斯大学和马里兰地区社区参与环境研究的纽带（华盛顿特区、巴尔的摩（简称“魅力城”）和宾夕法尼亚州）通过提供焦点、研究和领导促进变革性环境健康科学研究，以改善人类健康。首要任务是了解暴露于环境因素如何导致不良健康结果，然后将这些发现转化为行动，以保护和促进人们的健康和福祉马里兰州地区的弱势社区已了解并将继续指导该任务。通过社区领袖和来自 JHU 和 CHARMED 成员 (59) 之间的强有力的合作马里兰大学帕克分校基础、人口和社区的协同组合。 CHARMED 内的科学家参与促进解决基本问题的转化研究并将知识转化为行动，对马里兰州地区的人类健康产生重大影响，始终如一我们的使命是通过五个目标来实现：推进转化。环境健康研究将改善马里兰州地区的社区健康成果该中心的专题研究小组是： 1) 心肺健康和空气传播。污染物；2) 化学混合物和新兴污染物以及健康；3) 社区、社会和健康；健康的环境决定因素；4) 神经健康目标 2. 促进数据转化通过建立和加强与社区和利益相关者的战略伙伴关系，将知识转化为行动解决环境健康挑战并利用社区帮助制定 CHARMED 研究议程参与的研究方法（社区参与核心）目标 3. 建立和支持设施核心。结构 [综合健康科学设施核心 (IHSFC)，以及暴露特征描述和建模 IHSFC 将为人类受试者研究提供帮助。设计并采用生物统计学、大数据和生物信息学分析并整合“组学”，包括目标 4. 通过代谢组学数据来预测不良结果。全面的战略，包括培养（职业发展、核心研讨会）和支持（ESI 导师学者计划、试点资金、使用设施核心）早期和高级研究人员首次利用科学能力开展社区环境健康研究。中心将促进将中心的研究成果转化为基于证据的方法减轻环境暴露和预防疾病，以改善马里兰州及其他地区的人类健康。