Mechanism of pulmonary endothelial cell heterogeneity and its role in disease

肺内皮细胞异质性机制及其在疾病中的作用

基本信息

批准号：
10414872
负责人：
Lisandra Vila Ellis
金额：
$ 10.45万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10414872
关键词：
ATAC-seq Address Adult Affect Alveolar Alveolus Appearance Biology Blood Vessels Blood capillaries Breeding Bronchopulmonary Dysplasia Cancer Center Capillary Endothelial Cell Cell Maturation Cells Congenital alveolar dysplasia DNA Data Defect Development Developmental Biology Disease Embryo Endothelial Cells Endothelium Ensure Epithelial Epithelial Cells FOXF1 gene Failure Family Foxes Future Gases Genes Genetic Genetic Models Genetic Transcription Genomics Heterogeneity Human Hyperoxia Individual Interruption Link Location Lung Lung diseases Mentors Mesenchymal Modeling Morphology Mus Myofibroblast Names Neonatal Hyperoxic Injury Paper Phase Phenotype Physicians Physiological Play Population Postdoctoral Fellow Predisposition Premature Infant Process Publishing Pulmonary alveolar structure Research Retina Role SOX17 gene Sampling Scientist Signal Transduction Specific qualifier value Surface TP53 gene Testing Three-Dimensional Imaging Time Tissues Training VEGFA gene Vascular System Virus Diseases Work career career development cell fate specification developmental disease experience lung development mouse genetics mouse model mutant novel postnatal protein expression response single-cell RNA sequencing transcription factor vascular abnormality

项目摘要

PROJECT SUMMARY/ABSTRACT Candidate: Dr. Lisandra Via Ellis is a physician with extensive training in vascular biology and lung development. She is a postdoctoral fellow at MD Anderson Cancer Center seeking to understand how blood vessels develop in the lung and how this process is affected in disease. She just published her first, first-author paper in Developmental Cell. Career development: Dr. Vila Ellis' mentors include Dr. Jichao Chen, a successful scientist who studies developmental biology in the mouse lung, and Dr. Burton Dickey, a physician who has over 30 years of research experience in the lung. Additionally, Dr. Vila Ellis will have the support of many collaborators in the field, as well as a mentoring committee to ensure she meets the expected milestones of this proposal, and guarantee a smooth transition to an independent career. Research: Dr. Vila Ellis' work has shown that Vascular endothelial growth factor A (Vegfa) specifies a novel population of endothelial cells in the lung. These cells are transcriptionally and morphologically distinct, and in their absence the alveolar space is aberrantly enlarged, reminiscent of bronchopulmonary dysplasia. In the future, Dr. Vila Ellis will study how this specification process happens and what role these new cells play in lung disease. In summary, this proposal will address the mechanisms of pulmonary endothelial cell heterogeneity and help establish the lung endothelium as a key component in the origin of developmental diseases.

项目概要/摘要候选人：Lisandra Via Ellis 博士是一位在血管生物学和肺部发育方面接受过广泛培训的医生。她是 MD 安德森癌症中心的博士后研究员，致力于了解血管如何发育在肺部以及这个过程如何在疾病中受到影响。她刚刚发表了她的第一篇第一作者论文发育细胞。职业发展：Vila Ellis 博士的导师包括陈继超博士，他是一位成功的科学家，研究小鼠肺发育生物学，以及拥有 30 多年研究经验的医生 Burton Dickey 博士肺部的经验。此外，Vila Ellis 博士还将获得该领域许多合作者的支持作为指导委员会，确保她达到该提案的预期里程碑，并保证顺利过渡到独立职业。研究：Vila Ellis 博士的工作表明，血管内皮生长因子 A (Vegfa) 指定了一种新颖的肺内皮细胞群。这些细胞在转录和形态上是不同的，并且如果没有它们，肺泡腔就会异常扩大，让人想起支气管肺发育不良。在未来，Vila Ellis 博士将研究这种规范过程如何发生以及这些新细胞在肺中发挥什么作用疾病。总之，该提案将解决肺内皮细胞异质性的机制并有助于确定肺内皮是发育疾病起源的关键组成部分。