Pilot Projects Core

试点项目核心

• 批准号: 10634640
• 负责人: Mark John Thomas
• 金额: $ 18.99万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10634640
• 关键词: Address; Award; Awareness; Behavior; Collaborations; Communities; Complement; Consultations; Creativeness; Data; Evaluation; Faculty; Feedback; Fentanyl; Fostering; Funding; Goals; Grant; Individual; Industry; Infrastructure; Interneurons; Macaca; Minnesota; National Institute of Drug Abuse; Nucleus Accumbens; Parietal; Pilot Projects; Policies; Positioning Attribute; Procedures; Progress Reports; Recommendation; Reporting; Research; Research Personnel; Research Project Grants; Schedule; Technical Expertise; United States National Institutes of Health; Universities; Viral; Work; addiction; brain tissue; cell type; cellular imaging; connectome; connectome data; experience; innovation; member; neural circuit; novel; programs; research data dissemination; translational potential; web site

PROJECT SUMMARY: Pilot Projects Core The primary goal of the proposed NIDA Center for Neural Circuits in Addiction is to extend and enhance the research capabilities of NIH-funded addiction research projects at the University of Minnesota (UMN). The proposed Viral Innovation Core (VIC), Imaging Cells during Behavior Core (ICBC), Structural Circuits Core (SCC) and Addiction Connectome Core (ACC) will provide extensive technical expertise and infrastructure to individual investigators. To complement these efforts, the Pilot Project Core (PPC) will provide necessary means to foster new research and interactions by selecting and funding innovative projects that can synergistically combine the capabilities of the Research Cores to push the envelope in neural circuit research. The PPC, led by Center Director, Dr. Thomas, will engage a panel of Center faculty and External Advisors (i.e. the Pilot Panel) who will review proposals and present finalists to the Steering Committee for final determination. Following consultation with Program staff at NIDA, two to four projects will be funded each fiscal year. Proposals will be reviewed in accordance with standard NIH review criteria (significance, innovation, rigor and feasibility) and should address one or more of the following priorities: 1) ESIs; 2) New entrants to addiction research; 3) Demonstrate translational potential; 4) Engage a team of PIs who have not previously collaborated with one another; 5) Use Research Cores in a novel way; and/or 6) Develop substantial new capabilities for one or more Research Cores. Inclusion of preliminary data is not required. Applications for "bridge funds" or to extend ongoing projects will not be entertained. Finally, the Pilot Panel will also work on research dissemination so that Center members have the opportunity on a regular basis to see specific applications of Research Core functions, which we expect will stimulate creative new uses for these functions and new collaborations. The Core has two Specific Aims: Aim 1 will establish the Pilot Research Program with the first two recipient teams. These include a project from New Investigators, Drs. Patrick Rothwell and Esther Krook-Magnuson entitled: “Parsing Interneuron Diversity in the Nucleus Accumbens to Understand the Actions of Fentanyl” and a project from Drs. Matthew Chafee, Benjamin Hayden, and Jan Zimmernann titled “Front-Parietal Circuit Manipulation in Macaques.” Their team is composed of an ESI (Zimmermann) and two established investigators, forming a new collaborative team. Proposed awards are $50k over a period of up to two years. In Aim 2, the Pilot Panel, in consultation with the Steering Committee, will establish and maintain infrastructure, policies and procedures for award selection, ongoing evaluation and research dissemination of innovative pilot projects.

项目摘要：试点项目核心 拟议的 NIDA 成瘾神经回路中心的主要目标是扩展和增强 NIH 资助的明尼苏达大学 (UMN) 成瘾研究项目的研究能力。 提出的病毒创新核心（VIC）、行为过程中的细胞成像核心（ICBC）、结构电路核心 (SCC) 和 Addiction Connectome Core (ACC) 将提供广泛的技术专业知识和基础设施 为了补充这些努力，试点项目核心（PPC）将提供必要的支持。 意味着通过选择和资助可以的创新项目来促进新的研究和互动 协同结合研究核心的功能，推动神经回路研究的极限。 PPC 由中心主任 Thomas 博士领导，将聘请一个由中心教师和外部顾问组成的小组。 （即试点小组）将审查提案并将决赛入围者提交给指导委员会进行最终确定 与 NIDA 的计划工作人员协商后确定，每个项目将获得资助 2 至 4 个。 提案将根据 NIH 标准审查标准进行审查（重要性、 创新性、严谨性和可行性），并应解决以下一项或多项优先事项： 1) ESI 2) 新的 成瘾研究的参与者； 3) 展示转化潜力； 4) 聘请尚未参与成瘾研究的 PI 团队； 之前曾相互合作过；5) 以一种新颖的方式使用研究核心和/或 6) 开发实质性内容； 不需要包含一个或多个研究核心的新功能。 最后，试点小组也将不接受“过桥资金”或延长正在进行的项目。 研究传播，以便中心成员有机会定期看到具体的 研究核心功能的应用，我们预计这将激发这些功能的创造性新用途 以及新的合作。 核心有两个具体目标： 目标 1 将与前两名接收者建立试点研究计划 其中包括新研究者 Patrick Rothwell 博士和 Esther Krook-Magnuson 博士的项目。 题为：“解析伏核中间神经元多样性以了解芬太尼的作用”和 Matthew Chafee 博士、Benjamin Hayden 和 Jan Zimmernann 博士的项目名为“前顶叶回路” 对猕猴进行操纵。”他们的团队由 ESI（Zimmermann）和两名资深研究人员组成， 在“目标 2”中，提议的奖金为 5 万美元。 试点小组将与指导委员会协商，建立和维护基础设施、政策和 创新试点项目的奖项评选、持续评估和研究传播程序。