Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma

肥胖促进的胰腺癌的化学预防和机制

基本信息

批准号：
10605224
负责人：
Guido Erwin Michael Eibl
金额：
$ 112.28万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10605224
关键词：
Adipose tissue Advocate Animal Model Animals Anti-Inflammatory Agents Antidiabetic Drugs Biological Biometry Cell Culture Techniques Cell model Chemoprevention Clinical Collaborations Complex Data Development Diabetes Mellitus Dietary Component Disease Event Excision Genetic Genetic Engineering Goals Growth Health Promotion Inflammation Intercept Interdisciplinary Study International Intervention Intervention Studies Investigation Lipids Malignant Neoplasms Malignant neoplasm of pancreas Medical center Metformin Modeling Mutate Obesity Pancreas Pancreatic Adenocarcinoma Pathology Patient Care Patients Prevention strategy Preventive Primary Prevention Program Research Project Grants Recommendation Research Research Personnel Resource Sharing Risk Role Secondary Prevention Signal Transduction Tumor Promotion Tumor-associated macrophages cancer prevention chronic pancreatitis clinical practice design diet-induced obesity disorder prevention experience high risk innovation insight novel obese patients pancreas development pancreatic stellate cell prevent programs synergism translational impact translational potential tumor

项目摘要

PROJECT SUMMARY The Program Project Grant “Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma” constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of obesity in the development of pancreatic cancer. A detailed understanding of the biological mechanisms of action of obesity on pancreatic cancer development can form the rationale for biologically-based practices, scientifically-founded recommendations and interventional strategies in the prevention of this disease. The Program Project includes expertise from the UCLA campus and Cedars Sinai Medical Center. The Program is led by experienced pancreatic cancer researchers, who have organized investigative teams to develop highly interactive and synergistic research programs. The goal is to study the mechanisms, by which obesity promotes pancreatic cancer development and to explore interventional, cancer- preventing strategies. Innovative animal and cell culture models and novel concepts strongly supported by a wealth of preliminary data are proposed. The Projects will focus on: Adipose tissue inflammation in obesity- promoted pancreatic cancer (Project 1); Chemoprevention of pancreatic cancer with lipid-lowering and antidiabetic agents (Project 2); Role of the pancreatic fibro-inflammatory microenvironment in obesity- promoted pancreatic cancer (Project 3). The projects will utilize an Administrative Core (with Biostatistics Sub- Core) and a Shared Resource Core, the Animal and Cell Models Core (with Pathology Sub-Core). An External Advisory Board comprised of nationally and internationally recognized translational pancreatic cancer investigators and advocates has been assembled. The Program Project is designed for maximum integration and synergy of research and key investigators, who have been collaborating for more than 12 years so that the proposed Program can be focused on the most promising investigations with the greatest translational potential and impact.

项目概要项目资助“肥胖促进胰腺癌的化学预防和机制” 腺癌”构成了一个高度协作的多学科研究项目，旨在使肥胖在胰腺癌发生过程中的研究具有重大影响。了解肥胖对胰腺癌发展的生物学作用机制可以形成基于生物学的实践、有科学依据的建议和干预策略的基本原理该计划项目包括来自加州大学洛杉矶分校校园和 Cedars 的专业知识。该计划由经验丰富的胰腺癌研究人员领导，他们组织了研究团队开发高度互动和协同的研究计划，目标是研究肥胖促进胰腺癌发生的机制，并探索介入、癌症治疗预防策略。创新的动物和细胞培养模型和新颖的概念得到了大力支持。提出了大量的初步数据。这些项目将重点关注：肥胖症中的脂肪组织炎症。促进胰腺癌（项目1）；通过降脂和化疗来预防胰腺癌；抗糖尿病药物（项目 2）；胰腺纤维炎症微环境在肥胖中的作用促进胰腺癌（项目 3）。核心）和共享资源核心、动物和细胞模型核心（带有病理学子核心）。顾问委员会由国内和国际公认的转化胰腺癌专家组成研究人员和倡导者已经聚集在一起，该计划旨在实现最大程度的整合。以及研究和主要研究人员的协同作用，他们已经合作了 12 年多，以便拟议的计划可以专注于最有前途且具有最大转化潜力的研究和影响。