Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarction

心肌梗死后出血性再灌注损伤的心脏磁共振成像

• 批准号: 10392351
• 负责人: Walter R.T. Witschey
• 金额: $ 54.37万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10392351
• 关键词: 3-Dimensional; Acute myocardial infarction; Affect; Animals; Arrhythmia; Biocompatible Materials; Blood flow; Cardiac; Cessation of life; Clinical; Complication; Coronary; Coupled; Data; Deposition; Development; Edema; Evolution; Extracellular Matrix; Family suidae; Fibrosis; Generations; Goals; Health; Healthcare; Heart failure; Hemorrhage; High Prevalence; Histologic; Histology; Image; Imaging Techniques; Immunofluorescence Immunologic; Impairment; Implantable Defibrillators; Incidence; Infarction; Injury; Iron; Ischemia; Knowledge; Left Ventricular Function; Left Ventricular Remodeling; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Medical; Methods; Modeling; Morbidity - disease rate; Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial tissue; Myocardium; Patients; Persons; Phase; Physiologic pulse; Plasma; Predisposition; Preventive; Property; Relaxation; Reperfusion Injury; Reperfusion Therapy; Research Personnel; Risk; Severities; Signal Transduction; Specificity; Stains; Study of magnetics; Techniques; Testing; Time; Tissues; Ventricular Remodeling; Work; aggressive therapy; emission spectroscopy; experimental study; heart imaging; high risk population; imaging modality; improved; in vivo; interest; mortality; non-invasive imaging; novel; percutaneous coronary intervention; porcine model; pre-clinical; respiratory; restoration; risk stratification; stem cells; success; tool; translational goal

PROJECT SUMMARY Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year. Approximately 50% of HF is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. However, the success of reperfusion is partly limited by intramyocardial hemorrhage, which is the deposition of intravascular material into the myocardium. Hemorrhagic reperfusion injury has high prevalence and patients have a much greater risk of adverse left ventricular remodeling, risk of fatal arrhythmia, impaired systolic function and are hospitalized at a greater rate. Recent magnetic resonance imaging techniques have improved assessment of reperfusion injury, however, the association between MRI contrasts and reperfusion injury is highly unclear, and lacks specificity to IMH. Improved imaging of IMH and accurate knowledge about its spatial and temporal evolution may be essential for delivery of optimal medical therapy in patients and critical to identify patients most at risk for adverse ventricular remodeling. The overall goal is to investigate the magnetic properties of hemorrhage and develop MRI techniques with improved specificity to hemorrhage. New MRI techniques permit noninvasive assessment of the magnetic susceptibility of tissues and can target tissue iron. Therefore, we hypothesize that MRI imaging of myocardial magnetic susceptibility can map hemorrhagic myocardium. We will perform preclinical experiments in a pig model of reperfusion injury to validate these methods, compare them with conventional MR contrasts and develop MR methods for imaging live animals.

项目概要 心力衰竭 (HF) 是一种巨大的健康负担，影响着美国约 510 万人，并且是 每年造成 25 万人死亡。大约50%的心力衰竭是由心肌缺血引起的，需要 立即恢复流向受影响心肌的冠状动脉血流。然而，再灌注的成功 部分受到心肌内出血的限制，心肌内出血是血管内物质沉积到心肌中 心肌。出血性再灌注损伤的发生率很高，患者发生出血性再灌注损伤的风险也更高 不良的左心室重构、致命性心律失常的风险、收缩功能受损并需住院治疗 更大的比率。最近的磁共振成像技术改进了再灌注损伤的评估， 然而，MRI 对比与再灌注损伤之间的关联尚不清楚，且缺乏特异性 至IMH。改进 IMH 成像并准确了解其空间和时间演化可能是 对于为患者提供最佳的药物治疗至关重要，对于识别最有风险的患者也至关重要 不良心室重构。总体目标是研究出血的磁特性和 开发提高出血特异性的 MRI 技术。新的 MRI 技术允许无创 评估组织的磁化率并可以靶向组织铁。因此，我们假设 心肌磁化率的 MRI 成像可以绘制出血心肌图。我们将表演 在再灌注损伤猪模型中进行临床前实验以验证这些方法，并将其与 传统 MR 对比并开发用于活体动物成像的 MR 方法。

项目成果

Endogenous T1ρ cardiovascular magnetic resonance in hypertrophic cardiomyopathy.

肥厚型心肌病的内源性 T1α 心血管磁共振。

• 发表时间: 2021-10-25
• 作者: Thompson, Elizabeth W;Kamesh Iyer, Srikant;Solomon, Michael P;Li, Zhaohuan;Zhang, Qiang;Piechnik, Stefan;Werys, Konrad;Swago, Sophia;Moon, Brianna F;Rodgers, Zachary B;Hall, Anya;Kumar, Rishabh;Reza, Nosheen;Kim, Jessica;Jamil, Alisha;Desja
• 通讯作者: Desja

MR Intracranial Vessel Wall Imaging: A Systematic Review.

磁共振颅内血管壁成像：系统评价。

• 发表时间: 2020
• 作者: Song, Jae W;Moon, Brianna F;Burke, Morgan P;Kamesh Iyer, Srikant;Elliott, Mark A;Shou, Haochang;Messé, Steven R;Kasner, Scott E;Loevner, Laurie A;Schnall, Mitchell D;Kirsch, John E;Witschey, Walter R;Fan, Zhaoyang
• 通讯作者: Fan, Zhaoyang

Accelerated Cardiovascular Magnetic Resonance Imaging Using Radial Acquisition with Compressed Sensing

使用压缩感知径向采集加速心血管磁共振成像

• 发表时间: 2012-12-13
• 作者: S. Nam

Cross-modality and in-vivo validation of 4D flow MRI evaluation of uterine artery blood flow in human pregnancy.

4D 流 MRI 评估人类妊娠子宫动脉血流的跨模态和体内验证。

• 发表时间: 2021-11
• 作者: Hwuang, E;Wu, P H;Rodriguez;Langham, M;Wehrli, F W;Vidorreta, M;Moon, B;Kochar, K;Parameshwaran, S;Koelper, N;Tisdall, M D;Detre, J A;Witschey, W;Schwartz, N
• 通讯作者: Schwartz, N

Strategies for Implementing Machine Learning Algorithms in the Clinical Practice of Radiology.

在放射学临床实践中实施机器学习算法的策略。

• 发表时间: 2024-01
• 影响因子: 19.7
• 作者: Chae, Allison;Yao, Michael S;Sagreiya, Hersh;Goldberg, Ari D;Chatterjee, Neil;MacLean, Matthew T;Duda, Jeffrey;Elahi, Ameena;Borthakur, Arijitt;Ritchie, Marylyn D;Rader, Daniel;Kahn, Charles E;Witschey, Walter R;Gee, James C
• 通讯作者: Gee, James C