2022 Marine Natural Products Gordon Research Conference and Seminar

2022年海洋天然产物戈登研究会议暨研讨会

基本信息

批准号：
10391748
负责人：
Kerry Leigh McPhail
金额：
$ 2.85万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-15 至 2022-12-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10391748
关键词：
Academia Address Affinity Agriculture Anabolism Animals Antimalarials Antiparasitic Agents Area Artemisinins Biological Biological Process Biology Biotechnology California Cells Chemicals Clinical Collaborations Communicable Diseases Complex Complex Mixtures Data Development Discipline Disease Educational workshop Engineering Enhancement Technology Environment Equilibrium Evolution Female Fostering Gender Goals Government Health Hour Human Industrialization Industry Informatics Interdisciplinary Study International Investigation Lead Ligands Machine Learning Malignant Neoplasms Methodology Molecular Molecular Evolution Molecular Genetics Molecular Structure Molecular Target Natural Products Natural Products Chemistry Neurologic Oral Organism Outcome Pain Participant Personal Satisfaction Persons Phenotype Physiology Plants Postdoctoral Fellow Production Research Research Personnel Resolution Science Scientist Signal Pathway Source Structure Students Synthesis Chemistry System Technology Therapeutic Agents Training Translations Underrepresented Minority Underrepresented Populations United States National Institutes of Health Woman Work analytical tool avermectin bioactive natural products biological systems career career development climate change clinical development combat complex biological systems computerized data processing computerized tools data access data integration data tools educational atmosphere experience frontier graduate student human disease innovation inquiry-based learning lens macromolecule marine natural product metabolomics molecular imaging multiple omics nervous system disorder peer posters preclinical development programs scaffold screening social symposium synthetic biology tool training opportunity translation to humans

项目摘要

Project Summary Natural products research has contributed tremendously to human health and well-being, providing unique opportunities in animal health and agriculture as well as human disease treatment, as exemplified by the work of Nobel Laureates Tu Youyou (anti-malarial artemisinin) Satoshi Õmura (anti-parasitic avermectin). The evolution of natural products as potentially multifunctional ligands with highly specific affinities for disease- relevant targets has provided opportunities to develop therapeutic agents for cancers, infectious diseases and neurological disorders in particular. Natural products from the marine environment have provided unique molecular scaffolds that interact with cellular macromolecules and signaling pathways to effect changes in phenotype and physiology distinct from those caused by molecules from other sources. Multi-omics era transformational advances in the molecular genetics of natural product biosynthesis, and analytical technologies for characterizing natural products in the context of complex biological systems, stand to be leveraged further by computational tools that incorporate machine learning for accelerated and early determination of natural product structure and biological function. The 2022 Marine Natural Products Gordon Research Seminar (GRS) and Gordon Research Conference (GRC) is planned for March 6-11, 2022, in Ventura, California. The GRS is a unique forum for graduate students and postdocs to present and exchange new data and innovative ideas across the scope of basic and applied marine natural products research for human health and well-being. The GRC will bring together early career and established researchers from academia, industry, and government (including all of the GRS participants) to address the discovery, characterization and functional development of marine natural products. Presentations and discussion will address the molecular targets of biologically active natural products, including super resolution molecular imaging for natural product mechanisms; computational approaches to functional natural products discovery from complex mixtures; phenotypic screening for natural products discovery, synthetic biology for natural product engineering, synthetic strategies for natural product lead development, marine natural products in clinical development, and climate change and environmental solutions. Graduate students and postdocs will gain experience in poster and oral presentations at the short-format GRS immediately prior to the GRC, and thus be poised to develop career opportunities and new collaborations during the GRC via direct interaction with established leaders in the field. The collegial atmosphere of the GRS and GRC will foster innovative collaborations that bridge scientific disciplines and exchange of ideas among leaders in the field and new participants. NIH support will be directed towards participation of graduate student and postdoctoral presenters and discussion leaders at the GRS and GRC, as well as GRC presenters who are female and or from under-represented groups.

项目概要天然产物研究为人类健康和福祉做出了巨大贡献，提供了独特的动物健康和农业以及人类疾病治疗方面的机会，如该工作所例证诺贝尔奖获得者屠呦呦（抗疟疾青蒿素）Satoshi Õmura（抗寄生虫阿维菌素）。天然产物作为潜在多功能配体的进化，对疾病具有高度特异性的亲和力相关目标为开发癌症、传染病和疾病治疗药物提供了机会特别是来自海洋环境的天然产物为神经系统疾病提供了独特的治疗方法。与细胞大分子和信号通路相互作用以影响细胞因子变化的分子支架表型和生理学与其他来源的分子所引起的不同。天然产物生物合成的分子遗传学和分析技术的变革性进展为了在复杂生物系统的背景下表征天然产物，可以进一步利用结合机器学习的计算工具，可加速和早期确定天然产物结构和生物功能。2022年海洋天然产品戈登研究研讨会（GRS）和戈登研究会议 (GRC) 计划于 2022 年 3 月 6 日至 11 日在加利福尼亚州文图拉举行。为研究生和博士后提供和交流新数据和创新想法的独特论坛 GRC 将扩大海洋天然产物基础和应用研究的范围，以促进人类健康和福祉。汇集来自学术界、工业界和政府（包括所有 GRS 参与者）致力于解决海洋天然资源的发现、表征和功能开发问题产品的演示和讨论将涉及生物活性天然产品的分子目标，包括天然产物机制的超分辨率分子成像；从复杂混合物中发现功能性天然产物；天然产物的表型筛选；发现、天然产物工程的合成生物学、天然产物先导的合成策略开发、临床开发中的海洋天然产品以及气候变化和环境解决方案。研究生和博士后将在简短的 GRS 中获得海报和口头演示的经验紧接 GRC 之前，因此准备好在 GRC 期间发展职业机会和新的合作 GRC 通过与该领域的知名领导者直接互动 GRS 的学院氛围和 GRC 将促进创新合作，在科学学科和领导人之间的思想交流之间架起桥梁 NIH 的支持将针对研究生和新参与者。 GRS 和 GRC 的博士后演讲者和讨论领袖，以及女性 GRC 演讲者和/或来自代表性不足的群体。